Sentences with phrase «explored as targets»

«By means of basic research on model organisms, we are trying to understand human genome instability to identify elements, which, in the future, might be able to be explored as targets of new anti-tumour medicines,» explains the researcher responsible for the project and director of Cabimer, Andrés Aguilera.

The results of this study suggest that TAK1 should be further explored as a target for obesity treatment.

The amyloid - β protein precursor (AβPP) is cleaved by a transmembrane protease termed β - site AβPP cleavage enzyme (BACE1), which is being explored as a target for therapy and prevention of Alzheimer's disease (AD).

Telomerase is being explored as a target for therapeutic cancer vaccines.

Not exact matches

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Personally, I recommend exploring the idea as there are a lot of great Facebook advertising features, like its powerful ad targeting feature, worth taking advantage of that can certainly make it easier to get ahead.

As I have noted previously, Williams is an advocate of the Fed adopting such a target while Clarida has also explored its merits for monetary policy.

Our cooking spices and seasonings are targeted toward the discerning cook or for anyone who wants to expand their culinary experience with a wide variety of basic, as well as some of the more exotic Herbs and Spices to allow you to explore different cooking disciplines and applications.

Barcelona are already known to be exploring alternatives to Coutinho, should they not be able to secure his signature, with Christian Eriksen of Tottenham emerging as a key target.

These newly discovered molecular targets will allow the development of therapeutic strategies that may be explored as possible routes to eliminate leukemic cells» resistance to chemotherapy.

«This crater and its recently - formed deposits will be a prime target of study for the team as Dawn continues to explore Ceres in its final mapping phase,» said Paul Schenk, a Dawn science team member at the Lunar and Planetary Institute, Houston.

More importantly, it opens up exciting avenues of research to explore how restoration of p53 with drugs such as those that target ERAP1 can help to harness the immune system to recognise and destroy cancer cells.»

«If you put humans as the target, even though you are not going to make a human baby, it will be provocative, it will be misinterpreted, but people will engage,» says Andrew Hessel, a self - described futurist and biotechnology catalyst at Autodesk in San Francisco, California, a successful software company that specializes in 3D design programs for architecture and other fields that has been exploring synthetic biology applications in recent years.

«CRMP1 was not regarded as a therapeutic target so far, now it is worth exploring as a potential target,» said Wanker.

«We have identified a pathway in microglia that may be targeted to ultimately slow disease progression in ALS and are exploring potential therapeutic strategies and may have broader implications for diseases such as Alzheimer's and Parkinson's Disease amongst others.»

The BWH team also plans to explore whether targeting these unique T - cells hold promise as a treatment for rheumatoid arthritis.

Work by University of Manchester scientists has explored what allows some cases of Ductal Carcinoma in Situ (DCIS), a non-invasive form of breast cancer, to resist treatment and come back, as well as identifying a potential new target to improve the effectiveness of radiotherapy.

As next steps, Dr. Meltzer will use these findings to explore targeted brain stimulation that could boost the short - term memory of stroke patients.

NASA has selected two missions to further explore past targets — Saturn's largest moon, Titan, and the comet 67P / Churyumov - Gerasimenko — as the final candidates for its next billion - dollar robotic spacecraft, the agency announced today.

«We demonstrated that quality can be accomplished across the sites, but consider a different approach to the design,» she said, explaining that rather than treating negative symptom patients as one homogenous target, priority should be given to exploring the usefulness of novel mechanisms in separate negative symptom domains to better define the target population and maximize the chance of success before launching large phase III trials.

These findings open the door for researchers to potentially explore therapies that could target this area of the brain and disrupt its role in addiction, potentially with new drugs or other techniques such as deep brain stimulation or transcranial magnetic stimulation.

If we can show that this anomaly doesn't occur in healthy cells, we will be able to think about exploring these structures as possible therapeutic targets.»

«To our knowledge,» the authors wrote, «our study is the first to explore cfDNA systematically as a means to identify therapeutic targets not detectable from standard tissue - based testing in untreated metastatic disease.»

These promising results have already raised the interest of the pharmaceutical industry and led the researchers to patent DGKi as a drug target, as they are keen to explore the issue further, searching for molecules that strongly inhibit DGKi without causing side - effects.

Due to an increasing body of evidence which suggests that the host immune response may be critical to the efficacy of oncolytic virotherapy, Shah and his colleagues also developed an immunocompetent melanoma mouse model and explored treating with both stem cell loaded oHSV and immune checkpoint blockers such as the ones that target the PD - 1 / PD - L1 pathway.

The key experiments included for replication were selected because they examine the induction of POSTN expression in the pulmonary stromal fibroblasts and test the role of POSTN in primary tumor formation and metastatic efficiency, which are relevant as the role of POSTN as a possible prognostic marker and target for anticancer therapies is explored (Xu et al., 2012; Nuzzo et al., 2014).

Cancer research in the era of genome medicine necessitates an in - depth understanding of protein functions before they can be explored as therapeutic targets or diagnostic candidates.

The cellular processes that we have identified in this study as being important for the development of stomach cancer provide new targets for therapy that have not been explored before,» Dr. O'Reilly said.

To more fully explore the effects of compound on Bach1 activity, a luciferase reporter assay using the HMOX1 E2 ARE as a target was developed.

A new study exploring the NUDIX hydrolases in human cells provides attractive opportunities for expanding the use of this enzyme family as biomarkers and potential novel drug targets.

Their work encompasses several strategies, including: developing FL - HCC animal models to characterize tumor - immune interactions, exploring if a mutated protein associated with FL - HCC could be targeted by immunotherapy, identifying immune checkpoints that could potentially serve as targets for immunotherapy as well as biomarkers for analyzing patients, and evaluating the effectiveness of immunotherapy strategies against FL - HCC patient samples in the lab.

In particular, Dr. Azad's laboratory and clinical trials explore epigenetic therapy in combination with chemotherapy and immunotherapy to improve survival for patients, as well as molecularly targeted drugs.

A) To enable protein structure elucidation of membrane proteins the primary target of most therapeutics and large macromolecular complexes such as viruses; B) Design proteins with novel structure and / or function to explore novel approaches to protein therapeutics and deepen our understanding of protein folding pathways.

High fidelity Cas9s such as eSpCas9 and SpCas9 - HF should be explored to reduce off - target editing.

Differentiation: yellow = higher blue = middle purple = lower Resources provide opportunities to: - explore target audience for advertising campaigns - explore existing advertising campaigns - explore the use of persuasive language - explore the use of presentational features - analyse the effectiveness of advertising campaigns - explore the narratives of advertising campaigns - design a new soft drink and develop the advertising production plan - peer and self assess - explore representation - justify own design choices These resources could also be useful as part of an enrichment day / activity.

By learning a new language, or learning to use an existing language in new domains and contexts, students are able to notice, compare and reflect on things previously taken for granted; to explore their own linguistic, social and cultural practices as well as those associated with the target language.

In particular, we wished to explore the general issue of whether professional development, which we view as targeted support for leadership, is more or less important than pressure to increase achievement, which is a major component of state policy.

Instructional agility requires three components: (1) Learning targets with surface understanding as well as great depth (a description of what students are expected to learn) for that particular activity; (2) Formal or informal assessment information to explore what students understand and what they have yet to learn; and, (3) Instructional strategies to target misconceptions and deepen understanding of the learning goal.

Cerf said most schools targeted as the lowest achieving have one - third or fewer of their students at grade level in reading or math, and all remedies must be explored.

Instead, Subaru wants to grow as the brand of choice for what McHale calls «adventure - seekers,» people who enjoy exploring the outdoors, «fishing and hiking and so on... we want to take them on the trail... we're targeting those guys.»

For instance, in March 2012, nearly 60 percent of readers browsed — defined as exploring the catalog without a targeted search term — public library ebook collections to discover new content.

It helps us explore the authors vision and things like genre, target market, character descriptions, key objects / places, mood / tone, and time period, as well as the authors likes and dislikes, so I get to know them a bit more.

Also, explore top 10 features for developers as well as learn design and development tips that go beyond the phone and target tablet development as well.

Reach a targeted audience of history and nonfiction book readers with The Archive, which delves into the lost secrets of past by exploring the world's little - known histories as well as providing great nonfiction reading recommendations.

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This is the target area for fans of snorkelling as the tranquil and transparent waters make it extremely easy to explore and examine the seabed and discover the abundance of sea life that makes its home here.

The session - entitled Facebook and Targeting: Finding the People that Matter to You - will explore how powerful Facebook is as an advertising platform.

Targeted at independent and youth travellers, the joint campaign will promote Britain as a must - see destination and encourage travellers to explore the UK using a wide network of accommodation available on Hostelworld.com.

As you wander and explore, things happen in the world, from Public Events which you can track, to random encounters with high level targets, who when defeated leave behind a loot chest.

Ryder's long jumps and quick dashes complement the traversal - ready Nomad in preparing the player to explore as many of the alien worlds as they can find, even if they know a corridor full of moving targets is waiting at the end of each mission.