Sentences with phrase «exposed human and mouse»

The scientists then exposed human and mouse airways to various bitter compounds to gauge the effects.

Not exact matches

Unlike rodent models, which are developed from inbred strains of mice kept in controlled environments, companion animals, like humans, are genetically diverse and are exposed to many of the same environmental influences as their owners are.

After exposing both types of mice to endotoxin for two weeks, they tested their sensitivity to house dust mites, a common cause of allergies in both mice and humans.

For the new mouse model, the researchers exposed adolescent mice with at least one copy of a variant of the BDNF gene, which has been associated with anorexia and anxiety in mice and humans, to social stress and caloric restriction.

Because mice with intact immune systems are resistant to S. stercoralis infection, the researchers began with an immunocompromised strain of mice, and then exposed some to a synthetic steroid called methylprednisolone (MPA) that is commonly used to treat asthma in humans.

When mice exposed to both infection and stress were tested for PPI, however, they responded to the second loud noise with the same intensity even if they had been exposed to a previous tone — the same deficit seen in humans with schizophrenia.

In today's Cell, researchers report that the DNA on the end of human and mouse chromosomes forms a loop, with the exposed end tucked back into the DNA strand.

Galatzer - Levy analyzed data from large studies in humans and mice that involved «fear conditioning» and «fear extinction,» during which subjects receive a mild aversive stimulus when exposed to a sound or light, and «fear extinction learning,» during which conditioning is reversed by applying sound or light without the stimulus.

In the study, researchers exposed a handful of mouse and human T - cell receptors to hundreds of millions of peptides, and found hundreds of peptides that bound to each type.

However, in a final experiment, inhibiting molecules involved in the disruption of glycocalyx components prevented blood vessel leakage in both mice and human cells exposed to DENV NS1.

A striking example of this is MPP +, a well - established neurotoxin that specifically attacks the SNc dopaminergic neurons in lab mice, monkeys — and in humans: MPP +'s parent compound, MPTP, has caused numerous cases of Parkinson's - like syndrome in young people exposed to it in underground drug labs, or via contaminated street drugs.1

Three recent experimental studies focused on low consumption / exposure.949596 In one study, 29 smokers each consumed a single cigarette, immediately after which they had a significant decrease in blood vessel output power and significant increase in blood vessel ageing level and remaining blood volume 25 minutes later, as markers of atherosclerosis.94 In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.96

A recent study led by BSI member Professor Andrew Sewell from Cardiff University and published in the Journal of Clinical Investigation showed that a synthetic «mirror image» version of a protein belonging to the influenza A virus generated strong immune responses in human cells and mice, with the mice also being protected when exposed to a strain of influenza A.

To do this, they colonized the intestines of germ - free mice with a synthetic human gut microbiota and exposed the mice to either a plant fiber - free diet or a plant fiber - rich diet.

With rudimentary laboratories, one could argue that more was accomplished with regards to the effect of diet on cancer in the former half of the century, as revolutionary researchers like Tannenbaum, Rous, and their colleagues provided us with dozens of animal studies linking diet and cancer by exposing mice to free radical - laden vegetable oils.32, 33 Several decades later, two other researchers, Dayton and Pearce, provided one of the few studies revealing what happens when we give humans vegetable oils and their accompanying free radicals when they randomized men to a corn oil solution and a similar rise in cancer followed.34 It is no surprise that corn oil is often used in animal studies to cause cancer, as the ingestion of damaging free radicals predictably hastens cancer development.35 Furthermore, these scientists were the first to show that fasting, restricting calories, and cutting carbohydrates could lower the chance of cancer in animals exposed to dangerous chemicals and carcinogens.

1) that the rate of mutations increase in mice exposed to SHS and 2) that the spectra of mutations in the SHS exposed mice is the same as in non - smoker humans with lung cancer.