Instead, they simply
exposed human skin cells to four natural gene switches, called transcription factors.
Not exact matches
Martin Fussenegger of the Swiss Federal Institute of Technology in Zurich and his colleagues made this implant by genetically altering
human skin cells so that they would become darker in colour when
exposed to rising calcium levels.
In the study,
human melanocytes — the
cells that produce the
skin pigment melanin — were
exposed to estrogen levels usually seen during pregnancy.
Researchers at the Fund for the Replacement of Animals in Medical Experiments (FRAME) in Nottingham, have just finished the first stage of development, which draws on research showing that
human skin cells produce chemicals called cytokines when
exposed to chemicals that are irritants.
Gladstone scientist Dr. Sheng Ding has
exposed more chameleon - like qualities of the
human skin cell, using chemical cocktails to turn
skin cells into fully functional brain, heart, liver, and insulin - producing pancreas
cells.
Recent work from Fousteri Lab revealed a novel metabolic function of active transcription that is rapidly switched on globally in
human cells to promote genetic accuracy, and reduce the mutation burden in genotoxins -
exposed tissues, such as
skin and lung, thus actively participating in lowering oncogenesis.
We have developed a sequencing based approach to show similar in
human tissues, finding around a third of
cells in normal sun
exposed facial
skin carry cancer driver gene mutations.
In
humans, most basal
cell tumors develop in the areas of
skin most
exposed to sunlight (UVA and UVB radiation).