Not exact matches
Setton's
lab exposed the hiPSCs to a variety of different growth factors and
culture media to coax them into first developing markers for, and then fully forming into, notochord cells.
They
cultured the cells in the
lab for a day, then
exposed them for 3 days to a virus which contained the normal gene for the receptor.
By comparing the whole genome sequence of the
lab -
cultured resistant strain with a sibling strain that had not been
exposed to the drug, they were able to identify several mutations of interest in a number of genes.
In
lab cultures of human and yeast cells, the scientists stopped the harmful clumping of FUS proteins by
exposing them to phosphorylation, a process that makes precise changes to the amino acid building blocks of proteins, increasing their negative electric charge.