Treatment with HSV1 - TK is expected to kill transduced brain cells, thus
exposing tumor antigen.
Not exact matches
The remaining one - third of patients, composing a control group, received injections of their own dendritic cells that were not
exposed to
tumor antigens.
«So we hoped that by injecting antibodies hitched to isotopes into the blood that they'd be carried deep into the
tumor mass and would latch onto these now -
exposed antigens.
Singlet oxygen tends to rip apart
tumor cells in a manner that
exposes many new
tumor antigens to immune cells called dendritic cells, which, like police executing a dragnet, grab the
antigens and present them to T cells for closer inspection.
Researchers now think that irradiation sometimes kills
tumor cells in a manner that
exposes new
antigens to T cells, priming them to target other
tumor cells that carry them as well, says Wenbin Lin, a chemist at the University of Chicago in Illinois, and one of the authors of the current study.
There, they will be
exposed to
tumor antigens released from dying glioma cells through TK + valacyclovir - induced glioma cell death, and thus mediate a specific anti-malignant glioma immune response against remaining malignant glioma cells.