Sentences with phrase «express estrogen receptors»

Approximately 65 percent of all breast cancers express the estrogen receptor (ER +) and / or the progesterone receptor (PR +).

The example shown reveals that these estrogen agonists show the strongest connectivity to each other in MCF7, a human breast cancer cell line that expresses the estrogen receptor.

However, almost half of tumors that express the estrogen receptor, do either not respond well to the treatment or develop resistance with time.

Not exact matches

About 15 to 20 % of breast cancers are classified as «triple negative,» so called because these tumors do not express three key proteins that are biomarkers and / or drug targets for breast cancer: the estrogen receptor, the progesterone receptor, and HER2 (a member of the epidermal growth factor receptor family).

However, further testing showed that melanocytes express a separate, non-classical, estrogen receptor, GPER, as well as a non-classical progesterone receptor, PAQR7.

Triple - negative cancers are so called because they do not express receptors for the hormones estrogen and progesterone, nor for HER2 (human epidermal growth factor 2), and hence patients with these cancers are not candidates for treatment with modern hormonal therapies or the highly effective HER2 - targeted drug Herceptin (trastuzumab).

But recent work shows that while these cancers lack estrogen receptors, progesterone receptors, and aren't driven by the gene HER2, up to a third of these tumors express the androgen receptor — clinical trials are underway to inhibit the androgen receptor in these tumors in much the same way that the drug Tamoxifen inhibits estrogen receptor in estrogen - receptor - positive breast cancers.

Ince and his team found that although TNBC lacks the three receptors that fuel most breast cancers — estrogen receptors, progesterone receptors, and human epidermal growth factor receptor 2 — it does express androgen receptors (AR) and vitamin D receptors (VDR).

«Our data suggests that estrogen could be a therapeutic method for patients who express high levels of the estrogen receptor,» continues Professor Arsenian - Henriksson.

Using a new TaqMan PCR - based technique, the researchers screened a number of cancer cell lines from various tissues, and discovered that tRNA halves were specifically expressed in large quantities in sex hormone - dependent cancers, i.e., estrogen receptor (ER)- positive breast cancer and androgen receptor (AR)- positive prostate cancer that are driven by the hormones estrogen and testosterone.

Since estrogen receptors are expressed in the brain, it's no surprise that dietary isoflavones affect behavioral parameters.

Berkeley Lab researchers have developed the first clinically - relevant mouse model of human breast cancer to successfully express functional estrogen receptor positive adenocarcinomas.

Triple negative breast cancer is a type of breast cancer that does not express receptors for the hormones estrogen and progesterone, or for human epidermal growth factor.