Sentences with phrase «express higher levels»

In both instances, the ICM state appears to express higher levels of Nanog and this observation is consistent with the heterogeneous expression of Nanog reporter ES cells [8], [12].

BubR1: Mice engineered to express higher levels of BubR1 have lower levels of cancer, greater exercise capacity, and live modestly longer.

Checkpoint HR is a popular choice among mid-sized companies, with customers expressing high levels of satisfaction.

That's because the combo treatment would become a go - to, first - line option in patients regardless of whether or not they have the biomarker PD - L1 (Keytruda is far more effective in people who express high levels of the biomarker).

Both TRPV1 / WT and KO mice treated with capsaicin and TPA together exhibited higher COX - 2 protein levels than groups treated with TPA alone (Fig. 2A), and tumors from TRPV1 / KO mice expressed the highest level of COX - 2 as a result of treatment with capsaicin and TPA together (Fig. 2A).

Dem Chairman Jeremy Zellner said the party would evaluate his qualifications during its September 28th convention, while GOP chair Nick Langworthy has expressed a high level of respect for Sedita.

There is sound evidence that victims who attend conferences express high levels of satisfaction with the process and outcomes.

Using polymerase chain reaction methods that amplify DNA and Jones» assay that detects by - products of ALDH, the Johns Hopkins team found that regulatory T - cells express high levels of ALDH.

The results of a study of more than 100 human tumor samples show that the tumors expressing a high level of CCR3 present more frequent local dissemination.

As expected, study authors found a partisan gap between Democrats and Republicans in their stated opinions on climate change, with Democrats expressing the highest level of concern and scientific agreement.

They found aggressive breast tumors, including those that show metastatic traits, expressed higher levels of hnRNPM.

Several years ago, while creating a genetically engineered mouse that expresses high levels of the mouse HMGA1 gene to investigate its role in leukemia, Resar and her colleagues made the chance finding that the intestines of these animals were much larger and heavier than those of «wild - type» animals (or control mice that were not genetically modified).

When human orbital fibroblasts from TED patient tissue were compared to tissue from patients without TED, the researchers discovered that TED orbital fibroblasts expressed higher levels of AHRs than non-TED orbital fibroblasts.

In contrast, lymphocytes in both types of endothelial cell grafts expressed higher levels of genes known to be involved in dampening the immune response and inducing self - tolerance.

The new study revealed that pancreatic cancer cells not only send signals that make macrophages produce abnormal amounts of dectin - 1 surface receptors, but also that make tumor cells themselves express high levels of galectin - 9.

Once the women landed faculty positions, they expressed high levels of confidence in their abilities, value and contributions — especially in educating the next generation of scientists and engineers.

Unwanted neurons generally express high levels of a specific NMDA glutamate receptor.

«Sumudu has shown that liver cells that express high levels of the IFITM proteins are resistant to infection with the hepatitis C virus by blocking entry of the virus into the cells,» Associate Professor Beard says.

As these cells rapidly proliferate, they also express high levels of an enzyme known as activation - induced cytidine deaminase (AID), which induces mutations in their DNA.

«Our work also suggests that cancer cells expressing high levels of BOK may be particularly sensitive to inhibitors that target the proteasome or the ERAD pathway.»

Compared with non-human primate cells, human iPSCs expressed higher levels of these restrictors, called APOBEC3B and PIWIL2.

«Our data suggests that estrogen could be a therapeutic method for patients who express high levels of the estrogen receptor,» continues Professor Arsenian - Henriksson.

A complementary DNA encoding the human low density lipoprotein (LDL) receptor under control of the mouse metallothionein - I promoter was injected into fertilized mouse eggs, and a strain of mice expressing high levels of LDL receptors was established.

Developing this therapeutic approach could be crucial because the researchers found that patients whose tumors expressed high levels of both MVP components and Arf6 signaling proteins showed poor long - term survival rates.

The researchers showed that the iPS cell teratomas expressed high levels of certain genes that could trigger immune cells to attack.

Hashimoto et al.'s data suggest that future efforts might focus on breast cancer patients whose tumors express high levels of Arf6 signaling proteins, and which could therefore be susceptible to drugs that reduce the activity of Rab11b.

In addition, gastrocnemius muscles from IL - 15Rα — KO mice expressed higher levels of mRNA for the sarcoplasmic endoplasmic reticulum calcium ATPase - II (SERCA2) and lower mRNA expression and protein content of the calcium - binding protein calsequestrin (Figure 5, F and G).

A high γ reflects a high level of local neighborhood clustering within a network, and a short normalized travel distance λ expresses a high level of global communication efficiency within a network (Watts and Strogatz, 1998; Sporns et al., 2004; Bullmore and Sporns, 2009).

The researchers also showed that a new strain of mice, generated in the lab of co-senior author Eric Verdin, MD, at the Gladstone Institutes and engineered to express high levels of SIRT3, were inherently resistant to noise - induced hearing loss, even without administration of NR.

Monkeys shifted to the bottom rungs of the social order were more likely to express high levels of genes associated with inflammation.

Young mice that expressed high levels of human amyloid - β (but did not have pathological plaques) infected in the brain with Salmonella typhimurium were more likely to survive the infection compared to wild - type mice that did not express the peptide, Tanzi, Moir, and their colleagues found.

Express high levels of CCR5 on surface, also contain an HIV - 2 LTR linked to a green fluorescent protein (GFP) gene.

Furthermore, enhanced hiPS - HEP cells express high levels of the LDL receptor (Figure 5, Panel B) and take up fluorescently labeled LDL (Figure 5, Panel A).

All clones expressed high levels of Oct ‑ 4 (88 — 98 % positive), TRA ‑ 1 ‑ 60 (97 — 99 % positive), and SSEA - 4 (98 — 99 % positive).

Coukos, who is currently leading an ovarian cancer clinical trial sponsored by CRI's Clinical Accelerator, sought to understand why PD - 1 / PD - L1 immunotherapies are often ineffective for these patients, even though ovarian tumors are often infiltrated by «killer» T cells that recognize tumor - specific neoantigens and express high levels of PD - 1.

Further, consistent with T cell phenotypes in nontumor - bearing mice (Fig. 2), we observed an increased percentage of spleen - derived CD8 + T cells expressing high levels of the activation marker CD44 in DGKζ − / − or DKO mice that had been inoculated with tumor when compared with Cbl - b − / − or WT mice (Fig. 4C).

Express high levels of the androgen receptor, a key to testosterone production, and so are vulnerable to hormonal therapy.

(6) Moreover, subcutaneous adipose of prematurely - aged transgenic mice exhibited high levels of staining for the senescence marker senescence - associated - β - galactosidase (SAβ - gal) and expressed high levels of several established markers of senescence, including p21, p19, interleukin - 6, (insulin - like growth factor binding protein - 2 (Igfbp2), and Pai - 1; primary BubR1H / H; INK - ATTAC mouse embryonic fibroblasts forced artificially into senescence by oncogenic Ras or serial passage exhibited a subpopulation that was both GFP + and stained positively SAβ - gal.

We have established stably transfected HEK 293 cell lines expressing high levels of functional human ether - a go - go - related gene (HERG) channels.

As shown in 1A, similar to hESCs, hNSCs express high levels of SOX2, which is considered a key regulator of pluripotency [19], and NESTIN, a protein specific to NSCs [21]--[23].

hGDAsCNTF also expressed high levels of neurite - outgrowth inhibitory chondroitin sulfate proteoglycans, phosphacan and CSPG4, as well as the transcription factor Olig2 - all of which have been found to be upregulated in glial scar associated astrocytes.

Since murine NSCs already express high levels of Sox2 [14]--[16], it was tested whether these cells could be reprogrammed into iPS cells by only a few critical factors.

Similar to murine NSCs, human NSCs also express high levels of SOX2 and may therefore only require a limited set of factors for induction into pluripotency.

hGDAsCNTF have a more elongated morphology and expressed high levels of GFAP.

Inventors at MUSC have identified a unique human CD4 + T cell population that expresses high levels of surface CD26, termed CD26high T cells, which mediate durable antitumor immunity in vivo, and have immediate clinical relevance for designing new vaccines and cellular therapies.

Cells that express high levels of the transcription factor myc up - regulate glutaminase expression more than 10-fold [105].

Thus while the majority of the V + population existing in ES cell cultures are indistinguishable from undifferentiated ES cells, we also observe differentiated cells expressing high levels of the Venus transgene (arrows in Figure 2B) that resemble the high - level Venus expressors generated in response to differentiation and that probably represent spontaneous PrEn differentiation.

«When we found that the intestine expressed high levels of AIM2, we hypothesized that this gene may also play a role in regulating gut health,» Man said.

Figure 2A shows that in the presence of the cytokine LIF, the majority of Venus - positive cells (70 %) were also SSEA - 1 positive (V+S +), while LIF withdrawal both increased the percentage of the population expressing high levels of the Venus transgene (mean level of fluorescence increases approximately 2-fold, Figure 2A) and led to a substantial increase in a second Venus positive population that is SSEA - 1 negative (V+S −).

Moreover, many patients expressing high levels of HER2 progress or relapse despite receiving the best HER2 - directed treatments, and thus require novel treatment approaches.