Sentences with phrase «express human amyloid»

There exist several dozen lines of transgenic mice that express human amyloid - β protein precursor (AβPP) with Alzheimer's disease (AD)- linked mutations.

Specifically, rodents genetically modified to express human amyloid precursor protein (hAPP), which can lead to the debilitating plaques that form in the brains of Alzheimer's patients, seem to struggle to find the hidden platform relative to their healthy peers.

Not exact matches

Importantly, intraperitoneal inoculation of pancreatic homogenates containing IAPP aggregates into transgenic mice expressing human IAPP dramatically accelerates IAPP amyloid deposition, which was accompanied by clinical abnormalities typical of T2D, including hyperglycemia, impaired glucose tolerance, and a substantial reduction on β cell number and mass.

C. elegans expressing a modified form of human amyloid - β survived three or four more days following infection in the gut with Candida albicans, compared to wild - type worms that did not express the peptide.

Young mice that expressed high levels of human amyloid - β (but did not have pathological plaques) infected in the brain with Salmonella typhimurium were more likely to survive the infection compared to wild - type mice that did not express the peptide, Tanzi, Moir, and their colleagues found.