Sentences with phrase «expressed by a cell type»

Not exact matches

Indeed, because eggs are large cells that are relatively easy to manipulate, they are one of the favored cell types used by biologists to express foreign genes and to test gene function.

Scientists are hopeful that ultimately these cells could be transformed in the laboratory to yield specific cell types needed for a particular treatment, or to cross the «blood - brain barrier» by expressing specific therapeutic agents that are released directly into the brain.

S. mansoni IPSE binds to Immunoglobulin E (IgE), an antibody produced by the immune system that is expressed on the surface of basophils, a type of immune cell; and mast cells, another immune cell that mediates inflammation; and sequesters chemokines, signaling proteins that alert white cells to infection sites.

Two types of vaccines were used for the study: one constructed with genetically engineered DNA molecules that teach immune system cells to recognize premalignant cells expressing HPV16 E7 proteins, and one that is a non-infectious, engineered virus that targets and kills precancerous cells marked by HPV16 and HPV18 E6 and E7 proteins.

The researchers» investigations revealed that Del - 1 was expressed by at least three cell types in the bone marrow that support hematopoetic stem cells: endothelial cells, CAR cells and osteoblasts.

5 - HT1 receptors are expressed by type II taste cells and 5 - HT3 receptors are hypothesized to be expressed in gustatory nerve fibers (Jackson and Yakel, 1995; Wang et al., 2002).

One type, characterized by the presence of dynamic, unstable, nucleosomes, is found at highly expressed genes, such as those involved in the control of cell growth and division.

5 - HT released by type III taste cells activates adjacent type II taste cells that express the 5 - HT1A receptor, resulting in inhibition of type II cells (Herness and Chen, 2000; Huang et al., 2005; Jaber et al., 2014).

Current investigations focus on how BTLA expressed by different cell types attenuates disease.

We perform the transient silencing of several genes in parallel by RNA interference in order to identify those able to modify two types of DM1 biomarkers expressed by one DM1 - hES cell line progeny: the pathological intranuclear ribonucleoaggregates called foci and the insulin receptor splicing defect.

Immunological Invisibility Cloak Among them is Joel Linden, Ph.D., who recently reported that jamming signals transmitted by membrane proteins called adenosine receptors, which are expressed on T cells and on specialized cell - killing cells called NK cells, made both cell types more effective in halting lung metastasis of melanoma cells.

HVEM attenuates disease by interacting with BTLA expressed by at least two cell types: CD4 T cells and a non-lymphoid cell type.

By expressing foreign genes in target cell types, they hope to be able to specifically silence or activate cells of interest.

However, it is difficult to conclude from mixed tissue samples which genes are expressed by particular cell types.

So, the researchers forced expression of a dominant - negative TGF - β receptor type 2 (DNRII) onto LMP - specific T cells (DNRII - LSTs) that were specially designed to seek out and destroy proteins derived from the Epstein - Barr virus expressed by the tumor cells.

Here, we examine wild - type huntingtin's localization in cultured cells by expressing the full - length human protein tagged with enhanced green fluorescent protein (EGFP) within its unspliced genomic context.

But by placing the gene under the control of a «promoter» — an on - off switch for gene expression — from a gene (SM22a) that is expressed only in smooth muscle cells, Dr. Parmacek's team found that no matter which types of cells were infected, the gene was only «turned on» in smooth muscle cells.

The NG2 chondroitin sulfate proteoglycan is a membrane - spanning protein expressed by several types of immature progenitor cells, including oligodendrocyte progenitors, chondroblasts, skeletal muscle myoblasts, smooth muscle cells, and pericytes.

By injecting the modified viruses into transgenic mice that only express Cre recombinase in astrocytes, the researchers knew that any sequences flagged by the lox site inversion had successfully transferred their genetic cargo to the target cell type — here, astrocyteBy injecting the modified viruses into transgenic mice that only express Cre recombinase in astrocytes, the researchers knew that any sequences flagged by the lox site inversion had successfully transferred their genetic cargo to the target cell type — here, astrocyteby the lox site inversion had successfully transferred their genetic cargo to the target cell type — here, astrocytes.

However, if it is known which unique antigen is expressed by a tumour cell type, it should be possible to clone a T - cell receptor that has the capacity to bind to that antigen.