Sentences with phrase «expressed by each cell»

Immunophenotyping — a laboratory procedure used to study the proteins expressed by cells — is very commonly used in basic science research as well as in laboratory diagnostic testing.

Thus, signals coming from a given neuron provide information about odors that activate the specific receptor protein expressed by that cell.

She's looking at all the genes — including the original 19 and many more — expressed by each cell in the connected regions.

The vitamin D receptor belongs to the nuclear receptor superfamily of steroid / thyroid hormone receptors, and VDRs are expressed by cells in most organs, including the brain, heart, skin, gonads, prostate, and breast.

Not exact matches

But Canadian officials expressed skepticism, noting that the war had been grinding on and that «there may be little reliable evidence to gather» and that «organizers of whatever (improvised explosive device) cell (which) supported and directed the dead bomber have been killed» by special forces.

Indeed, because eggs are large cells that are relatively easy to manipulate, they are one of the favored cell types used by biologists to express foreign genes and to test gene function.

One clear positive element in the stem - cell debate for me was hearing the top researchers in biomedical science reinforce The Catechism of the Catholic Church (CCC 343: «Man is the summit of the Creator's work, as the inspired account expresses by clearly distinguishing the creation of man from that of other creatures»).

So, the researchers — headed by Professor of Physics and Biological Sciences Shane Hutson and Associate Professor of Cell and Developmental Biology Andrea Page - McCaw — targeted cells on the back of fruit fly pupae that expressed a protein that fluoresces in the presence of calcium ions.

Because prostate cancer does not express SLC13A5, the growth of prostate cancer cells was unaffected by suppressing SLC13A5 expression.

The protein expressed by the gene is thought to bind to serotonin receptor molecules and ferry them to the cell surface, positioning them to receive serotonin's signals from neighboring cells.

The compound (right panel) has a scorpion - like shape with two arms grabbing EphA2 - expressing cancer cells, and a tail (brown) constituted by a cytotoxic chemotherapeutic agent (paclitaxel used in this work).

A team led by Byeong - Chun Lee of Seoul National University in South Korea created the dogs by cloning fibroblast cells that express a red fluorescent gene produced by sea anemones.

One way cancer cells do this is by expressing a protein ligand that binds to a receptor on the T cells to prevent the T cell from recognizing and attacking the cancer cell.

Yu said the impairment of sensory nerve regeneration in diabetic corneas is due to decreased ciliary neurotrophic factor, as evidenced by the fact that dendritic cells express ciliary neurotrophic factor (CNTF) in normal and healing corneas but decrease in diabetic corneas due to the reduced infiltration of dendritic cells.

Using polymerase chain reaction methods that amplify DNA and Jones» assay that detects by - products of ALDH, the Johns Hopkins team found that regulatory T - cells express high levels of ALDH.

Here they have been infected by a herpes virus that carries a «brainbow cassette,» which makes cells express proteins that are tagged with a variety of fluorescent colors.

The findings by a team of Massachusetts General Hospital (MGH) investigators, which will be published in the April 24 issue of Cell and are receiving advance online release, support the importance of epigenetics — processes controlling whether or not genes are expressed — in cancer pathology and identify molecular circuits that may be targeted by new therapeutic approaches.

«We found that a protein expressed by gut bacteria called Bacteroides works to prevent IBD by rapidly recruiting white blood cells to kill a cell of the immune system that is responsible for orchestrating IBD,» says McCoy.

CRH, in turn, triggered production of the cell surface protein FasL; trophoblasts expressing FasL then form a protective shield of sorts around the embryo by forcing any attacking immune cells to self - destruct.

Previous studies have found that brown fat can be coaxed into action by activating the β3 - adrenergic receptor, which is expressed on the surfaces of brown and white fat cells, as well as on cells of the urinary bladder and other tissues.

This protein is expressed at relatively high levels in proliferating precursors and non-neuronal cells but down - regulated in developing neurons by a brain - enriched regulatory RNA called miR - 9.

By tallying the various RNA molecules in a cell, researchers can tell which genes are active — or «expressed» — and to what degree.

Scientists are hopeful that ultimately these cells could be transformed in the laboratory to yield specific cell types needed for a particular treatment, or to cross the «blood - brain barrier» by expressing specific therapeutic agents that are released directly into the brain.

Itch responses were blocked by toxin - mediated ablation of Nppb - receptor — expressing cells, but a second neuropeptide, gastrin - releasing peptide, still induced strong responses in the toxin - treated animals.

A team of researchers led by Rodrigo Lacruz, MSc, PhD, assistant professor in the Department of Basic Science and Craniofacial Biology at NYU College of Dentistry, has published a paper in Scientific Reports (5:15803) titled «Dental enamel cells express functional SOCE channels,» which reports the results of a study showing for the first time the mechanism of calcium transport essential in the formation of dental enamel.

Researchers from the Eaton - Peabody Laboratories of the Massachusetts Eye and Ear and Harvard Medical School have created a new mouse model in which by expressing a gene in the inner ear hair cells — the sensory cells that detect sound and sense balance — protects the mice from age - related hearing loss (ARHL) and noise - induced hearing loss (NIHL), the two most common forms of deafness.

This clinical trial sponsored by Juno Therapeutics is testing JCAR017, which targets the CD19 protein expressed on most B - cell leukemias and lymphomas.

Their study, the researchers say «establishes a role for cell wall - associated GAG in mediating resistance to killing of Aspergillus by NETs and provides the first example of a virulence factor of A. fumigatus that is able to mediate enhanced virulence when expressed in a less pathogenic Aspergillus species».

In PLAT - 02, the CAR T cells are reprogrammed to recognize and target the CD19 protein that is expressed by most precursor B acute lymphoblastic leukemia cells.

They will examine the safety and feasibility of administering cancer - fighting chimeric antigen receptor (CAR) T cells that have been reprogrammed to target the CD22 protein expressed by some leukemia cells.

They found that infection of the narrowest airways of the lung by PIV3 alone caused moderate levels of inflammation, but after infection by PIV3 expressing RSV NS2, the epithelial cells lining the narrow airways were shed rapidly into the airway lumen.

«The cells infected by PIV3 expressing the NS2 gene of RSV looked exactly like RSV - infected cells,» Liesman said.

A radio - labeled human antibody binds to the viral gp41 protein expressed on the surface of the HIV - infected human lymphocyte and the cell is killed by alpha radiation delivered by the antibody.

Because the MS4A proteins are expressed on many cells in the body, the researchers will also test whether they detect cues that are generated by the body itself.

Wellcome Trust Sanger Institute scientists and their collaborators have developed a new analysis tool that was able to show, for the first time, which genes were expressed by individual cells in different genetic versions of a benign blood cancer.

Single - cell mouse embryos were infected in vitro with recombinant lentiviral vectors to generate transgenic mice carrying the green fluorescent protein (GFP) gene driven by a ubiquitously expressing promoter.

«Because many broadly expressed genes that play key roles in essential cellular functions are under the control of cell - specific enhancers, the ability to affect enhancer function by knocking down eRNAs could potentially provide a new strategy for altering gene expression in vivo in a cell - specific manner,» said Glass, noting that in his research, anti-sense oligonucleotides were developed in conjunction with Isis Pharmaceuticals, which suppressed enhancer activity and reduced expression in nearby genes.

The bone matrix being produced by cells is stained red in samples of cells that are sorted for not expressing ALPL (left), sorted for expressing ALPL (right), and left as an unsorted control (center).

Research led by Ed Morrisey, PhD, professor of Medicine and Cell and Developmental Biology in the Perelman School of Medicine, University of Pennsylvania and scientific director of the Penn Institute for Regenerative Medicine, has identified hundreds of these lncRNAs, sometimes called the «genomic dark matter,» that are expressed in developing and adult lungs.

S. mansoni IPSE binds to Immunoglobulin E (IgE), an antibody produced by the immune system that is expressed on the surface of basophils, a type of immune cell; and mast cells, another immune cell that mediates inflammation; and sequesters chemokines, signaling proteins that alert white cells to infection sites.

Partial activation of the yeast pheromone response pathway by beta - adrenergic receptor agonists was achieved in cells coexpressing h beta - AR and a mammalian G protein (Gs) alpha subunit - demonstrating that these components can couple to each other and to downstream effectors when expressed in yeast.

After being infused back into patients» bodies, these newly built cells both multiply and seek out a peptide expressed by the antigens NY - ESO - 1 and LAGE - 1 found in multiple myeloma cancer cells.

An anonymous member of the research team expressed impatience with the lab bacteria by leaving graffiti on a blackboard: «Hey cells, GROW UP!»

For the PET scan they used a protein that is expressed by microglia and astrocyte cells, which are known to be active in neuroinflammation.

What's more, the disrupted circadian oscillations in the MYC - expressing cancer cells could be partially rescued by inhibiting expression of REV - ERBα.

Receiver cells «read» the signal concentration and make red, white or blue stripes by expressing genes.

Two types of vaccines were used for the study: one constructed with genetically engineered DNA molecules that teach immune system cells to recognize premalignant cells expressing HPV16 E7 proteins, and one that is a non-infectious, engineered virus that targets and kills precancerous cells marked by HPV16 and HPV18 E6 and E7 proteins.

At Gritstone Oncology, researchers pair deep learning with multi-omic profiling to characterize a patient's cancer and identify unique antigens that aren't expressed by healthy cells.

At the Dana - Farber Cancer Institute and the Broad Institute, for instance, Todd Golub, a specialist in the genetics of cancer, had spent a decade learning how to identify malignant tumors by the pattern of protein - coding messenger RNAs expressed in their cells.

But Raz and colleagues have found that TPRV1 is also expressed by epithelial cells of the intestines, where it is activated by epidermal growth factor receptor or EGFR.