Sentences with phrase «expressed cell surface»

«That is why detecting early esophageal cancer with fluorescent probes to highly expressed cell surface proteins are necessary.»

Unlike CD8 + DCs that express the cell surface protein CD205, CD8 — DCs, which are positive for the 33D1 antigen, are specialized for presentation on major histocompatibility complex (MHC) class II.

Not exact matches

The protein expressed by the gene is thought to bind to serotonin receptor molecules and ferry them to the cell surface, positioning them to receive serotonin's signals from neighboring cells.

Many cells expressing the HIV - 1 Gag protein were detected at the surface of the nasopharyngeal tonsil or adenoid.

Here, cells expressing the interacting domains of v - and t - SNAREs on the cell surface were found to fuse spontaneously, demonstrating that SNAREs are sufficient to fuse biological membranes.

CRH, in turn, triggered production of the cell surface protein FasL; trophoblasts expressing FasL then form a protective shield of sorts around the embryo by forcing any attacking immune cells to self - destruct.

Previous studies have found that brown fat can be coaxed into action by activating the β3 - adrenergic receptor, which is expressed on the surfaces of brown and white fat cells, as well as on cells of the urinary bladder and other tissues.

«The antibody binds to a specific protein, called CD44s, which is expressed on the surface of pancreatic cancer stem cells.

pAPCs express toll - like receptors on their surfaces that recognize and trap molecular patterns called antigens on bacteria, food and our own cells.

For the study, Dr. Dadachova's team paired the monoclonal antibody (mAb2556) designed to target a protein expressed on the surface of HIV - infected cells with the radionuclide Bismuth - 213.

A radio - labeled human antibody binds to the viral gp41 protein expressed on the surface of the HIV - infected human lymphocyte and the cell is killed by alpha radiation delivered by the antibody.

The new study revealed that pancreatic cancer cells not only send signals that make macrophages produce abnormal amounts of dectin - 1 surface receptors, but also that make tumor cells themselves express high levels of galectin - 9.

In addition, exosomes are being co-opted as a treatment modality and have been modified through their parental cells to express a targeting moiety or marker tag on their surface.

S. mansoni IPSE binds to Immunoglobulin E (IgE), an antibody produced by the immune system that is expressed on the surface of basophils, a type of immune cell; and mast cells, another immune cell that mediates inflammation; and sequesters chemokines, signaling proteins that alert white cells to infection sites.

In addition, exhausted CD8 T cells start to express inhibitory cell surface receptors that receive and feed inhibitory signals into the cell establishing a negative feedback loop.

Ovarian cancer researchers have identified a protein biomarker expressed on the surface of tumour cells in high - grade serous ovarian cancer, the most common and lethal subtype of the disease.

Neutralization could be measured in cell culture with real virus or a recombinant vaccine virus expressing the Ebola virus surface protein, Günther says.

Although myeloma is, like leukemias and lymphomas, a cancer involving white blood cells known as lymphocytes, myeloma cells don't traditionally express CD19 on their surface because they arise from the most mature type of lymphocytes — plasma cells.

T cells are collected from the patient's blood and genetically engineered to express cell - surface proteins called CARs, which recognize specific molecules found on the surface of cancer cells.

In earlier research, Barbolina discovered that a fractalkine receptor — a protein found on the cell surface — is expressed in the majority of ovarian cancer cases.

Once activated, the circuit expresses proteins designed to direct the immune system to target the tumor cells, including surface T cell engagers, which direct T cells to kill the cells.

Significantly, cells with reduced mtDNA became self - renewing and expressed specific cell surface markers characteristic of breast cancer stem cells.

The explanation: Heat caused the HEV cells to express on their surface higher levels of two so - called «homing» molecules, ICAM - 1 and CCL21, which make lymphocytes tightly adhere to the HEV cells.

The group was then able to sort the cells using markers expressed on the cell surface, to help pull out successfully edited cells for research, and eventually for therapeutic use.

To devise a potential new therapy, the investigators engineered a population of neural stem cells to express a potent version of a gene called TRAIL, which codes for a molecule that activates cell - death - inducing receptors found only on the surface of cancer cells.

Those cells were then purified using the proteins they expressed on their surfaces.

However, this is unlikely given that the frequency of in - frame mutations remained stable over nearly four weeks in culture, that there was no significant increase in cell death between control cultures and those treated with X4 - ZFNs, and that the most common in - frame mutant was not expressed on the cell surface and thus can not maintain functionality.

The resulting CXCR4Δ18 protein, containing a six - residue deletion in ECL2, could potentially be expressed at the cell surface and support HIV infection.

Blincyto (blinatumomab) is designed to treat cancers expressing a molecule called CD19 — found on the surface of B cell ALL and also non-Hodgkin's lymphoma.

It is interesting that YFP - expressing pluripotent cells were rarely detected in the lens, yet often present in the cornea since the surface ectoderm forms both the lens and the cornea.

Mesenchymal stem cells express a surface protein called α4β1 integrin as they turn into osteoblasts.

YFP expressing cells are also observed in the surface ectoderm and left half of the forebrain (G).

But the new data reveals that oRGs bring a support group with them: The cells express genes for surface markers and molecular signals that enhance their own ability to proliferate, the researchers found.

The mRNAs are delivered to the body and direct cells to produce and express both antigenic proteins on the cell surface, much like a native infection would do but without the ability to cause disease or spread.

There are no specific markers to identify them; however, they are negative for hematopoietic cell markers like CD34 / 45 / HLA - DR and express CD90 / 73/105 on their surface 2, 3, 4.

The gp160 is expressed on the surface of infected cells, an

While learning how to culture rhinovirus C, Palmenberg's research team discovered the virus only infects certain lung cells that express a particular genetic form of a cell - surface molecule called cadherin - related protein 3 (CDHR3).

This is a derivative of the TZM - bl cell line, engineered by lentiviral transduction to stably express human FcγRIIb on the surface.

This is a derivative of the TZM - bl cell line, engineered by lentiviral transduction to stably express human FcγRI on the surface.

The mRNA directs cells to produce and express the proteins on the cell surface, much like a native infections would do, but without the ability to cause disease.

Binds to cell surface expressed oligomeric gp120.

This is a derivative of the TZM - bl cell line, engineered by lentiviral transduction to stably express human FcγRIIIa on the surface.

The vaccines deliver mRNA encoding for hemagglutinin to the body's cells, directing them to produce and express this viral antigenic protein transiently on the cell's surface, much like a native infection would do, but without the ability to cause disease.

CD20 is a B - lymphocyte surface molecule that is widely expressed during B - cell ontogeny, from early pre-B-cell developmental stages until final differentiation into plasma cells.

Interestingly, an increased fraction of the cell population was found to express CD44 + / CD24 - / ESA + cell surface markers.

High throughput injection of poly (A) + RNAs into Xenopus oocytes (in collaboration with Biopredic International) to obtain cells expressing molecules characteristic of certain cell types on their surface.

Every T cell type expresses different cell surface markers and secretes different cytokines.

In this trial, researchers genetically modified patients T - cells to express a CAR targeting a surface antigen called CD22.

Positive clones were then differentiated using defined serum - free conditions outlined in Ng, et al [7], which overall gave rise to a CD45 + CD56 + CD117 − CD94 + population of cytotoxic NK cells [8] expressing the CD4 construct and other surface markers in a similar manner to peripheral blood NK cells.

g defined serum - free conditions outlined in Ng, et al [7], which overall gave rise to a CD45 + CD56 + CD117 − CD94 + population of cytotoxic NK cells [8] expressing the CD4 construct and other surface markers in a similar manner to peripheral blood NK cells.