Sentences with phrase «expressed genes in a genome»

The Yale - led study performed whole exome sequencing ¬ — a technique for sequencing all the expressed genes in a genome ¬ — on TNBC tumors to identify mutations in specific genes or pathways that may indicate response or resistance to the standard of care, which is anthracycline / taxane (ACT) chemotherapy.

Not exact matches

Biologists now know that the genome sequence holds only a small part of the answer, and that key elements of development and disease are controlled by the epigenome — a set of chemical modifications, not encoded in DNA, that orchestrate how and when genes are expressed.

«We have fewer genes in our genome than people originally expected because there's this other layer of complexity in the proteome, the collection of proteins expressed by the genome.

In the Lyme bacteria's genome, the VlsE gene is preceded by «cassettes» which are normally not expressed, or made into individual proteins, but can recombine with VlsE to alter the expressed protein and thus present a novel challenge to a host's immune defenses.

In one study, geneticist Joseph Ecker at the Salk Institute in California took various stem cell lines reprogrammed from skin, fat, and other tissues and examined each line's genome for dna methylation, chemical marks that alter how genes are expresseIn one study, geneticist Joseph Ecker at the Salk Institute in California took various stem cell lines reprogrammed from skin, fat, and other tissues and examined each line's genome for dna methylation, chemical marks that alter how genes are expressein California took various stem cell lines reprogrammed from skin, fat, and other tissues and examined each line's genome for dna methylation, chemical marks that alter how genes are expressed.

Bagchi and his team focused on a region of the genome, 8q24, which contains the MYC gene and is commonly expressed in cancer.

In 1991 he invented a quick way to find human genes, using expressed sequence tags, after the senior scientists at the Human Genome Project had said it wouldn't work.

After clearing the samples of variance due to technical artifacts that could potentially confound the findings, they performed 3.5 trillion statistical tests against every mutation in the genome compared to every expressed gene in each of the 44 tissues.

These open chromatin regions are known to be key locations in the genome that control which genes are expressed and which aren't.

One of the mechanisms driving alterations in gene expression is epigenetic change, where the female is able to change her offspring's genome to cause certain genes to be expressed differently.

Besides recognizable genes, vast swathes of the genome consist of regulatory networks that control how genes are expressed in cells.

The group, led by genome scientist Yoshihide Hayashizaki, has developed techniques to count how frequently a gene is expressed — the process by which DNA is transcribed into RNA, which in turn codes for a protein.

Dudley's team found that HAR - associated schizophrenia genes are found in regions of the genome that influence other genes expressed in the prefrontal cortex, a brain region just behind the forehead that is involved in higher - order thinking.

So they bred mutant mice in which the imprinting - control regions for these genes were deleted, allowing them to be expressed the way they would be in the male genome.

Mature miR - 7 is individually transcribed and processed from 3 different gene locus in human genome, and it is highly expressed in parts of the brain, eye, and pancreas, suggesting its role in the development of these organs (20 — 22).

Dr. Zhu said loss of the gene and the protein it expresses may accelerate regeneration by reorganizing how genes are packaged in the genome so that the cells can more easily switch back and forth toward a more regenerative state, sort of like a toggle switch.

Here we show variation between incompatible Culex strains in two Wolbachia ankyrin repeat - encoding genes associated with a prophage region, one of which is sex - specifically expressed in some strains, and also a direct effect of the host nuclear genome on CI rescue.

The variant surface antigens expressed on Plasmodium falciparum - infected erythrocytes are potentially important targets of immunity to malaria and are encoded, at least in part, by a family of var genes, about 60 of which are present within every parasite genome.

«Many therapeutic genes are only expressed transiently before they get shut off by the host cell or they are not expressed as expected because they don't occupy the same position in the genome as the natural genes,» explains postdoctoral researcher and co-first author Keiichiro Suzuki.

This permissive expression includes lineage - specific and tissue - specific genes, non-coding regions of the genome that are normally «silent,» and repetitive sequences in the genome, which comprise the majority of the mammalian genome but are also normally not expressed.

This text covers topics ranging from plant genome structure and the key control points in how genes are expressed, to the mechanisms by which proteins are generated and how their activities are controlled and altered by posttranslational modifications.

The scientists had strategically inserted these foreign DNA «markers» at particular points along the genome, next to genes expressed only in embryonic stem cells.

Doing this will help us identify what parts of the genome actually are protein - coding genes, but it will also tell us something about those genes» functions — a gene that is strongly expressed in a leaf, but not in flowers or root tissue, is probably important for the specific functions of leaves.

Beyond the genetic information contained in DNA, the researchers examined patterns of DNA methylation — a molecular modification to DNA that affects when and how strongly a gene is expressed — across the genome in pairs of identical male twins.

Remillard cites a 2013 study led by Swedish geneticist Erik Axelsson, reported in the journal Nature, in which «he reports that in a domestic dog's vs. wolf's genome comparison, three genes responsible for the digestion of dietary starch were expressed 7 -12-fold higher levels in the dog compared to the wolf.»

In their work on compulsive blanket and flank sucking in Dobermanns, the authors identified a single locus with genome - wide significance within the gene Cadherin 2 (cdh2), a widely expressed gene involved in pre - and post-synaptic adhesioIn their work on compulsive blanket and flank sucking in Dobermanns, the authors identified a single locus with genome - wide significance within the gene Cadherin 2 (cdh2), a widely expressed gene involved in pre - and post-synaptic adhesioin Dobermanns, the authors identified a single locus with genome - wide significance within the gene Cadherin 2 (cdh2), a widely expressed gene involved in pre - and post-synaptic adhesioin pre - and post-synaptic adhesion.