Sentences with phrase «expressed in cancer cells»

Abnormally expressed in cancer cells, the protein was found to promote the proliferation of B cells in B - cell acute lymphoblastic leukemia

We learn which specific genes are expressed in cancer cells and how a patient may respond to different therapies, so that we can select the most appropriate targeted treatment for the particular cancer.

«Role of RNA binding protein in driving cancer, leukemia study reveals: Abnormally expressed in cancer cells, the protein was found to promote the proliferation of B cells in B - cell acute lymphoblastic leukemia.»

They found that the number of copies of lncRNA genes on a chromosome consistently change in 12 different cancer types and lncRNA genes are widely expressed in cancer cells.

Not exact matches

The compound (right panel) has a scorpion - like shape with two arms grabbing EphA2 - expressing cancer cells, and a tail (brown) constituted by a cytotoxic chemotherapeutic agent (paclitaxel used in this work).

«In addition, changes in how the genes are expressed (turned on or off) could be used in the future to predict how and when the cancer cells will spread to other parts of the body and how fast they will grow.&raquIn addition, changes in how the genes are expressed (turned on or off) could be used in the future to predict how and when the cancer cells will spread to other parts of the body and how fast they will grow.&raquin how the genes are expressed (turned on or off) could be used in the future to predict how and when the cancer cells will spread to other parts of the body and how fast they will grow.&raquin the future to predict how and when the cancer cells will spread to other parts of the body and how fast they will grow.»

«We think that these genes, which are normally only expressed in the placenta to facilitate invasion, are becoming reactivated in cancer cells and supporting invasion in this context too,» she says.

In the GD2 CAR - T treated animals, the residual cancer cells did not express GD2, suggesting that these remaining cells were not vulnerable to the immune therapy and might be able to cause the cancer to recur.

The findings by a team of Massachusetts General Hospital (MGH) investigators, which will be published in the April 24 issue of Cell and are receiving advance online release, support the importance of epigenetics — processes controlling whether or not genes are expressed — in cancer pathology and identify molecular circuits that may be targeted by new therapeutic approaches.

«We have been able to show that this protein is highly expressed in metastatic triple - negative breast cancer, and when we are depleting it from triple - negative breast cancer cells, we found that the cancer cells are not metastasizing,» Dr. Paul said.

They found that atypical protein kinase c lambda / iota, which is known to influence cell growth, was highly expressed and phosphorylated in metastatic breast cancers.

The scientists have shown that, in all cancers, a sort of «identity crisis» is observed in cancerous cells: in the organs or tissues in which a tumor develops, genes specific to other tissues or to other stages of the development of the organism express themselves in an aberrant manner.

The group looked at an oncogene, AF1q discovered in Tse's lab, which is expressed in hematological cancer cells and is known to be related to multiple myeloma.

In 1994, scientists first realized that putting the EGFP gene into cells made them glow green, making it possible to easily visualize them: ever since, scientists have generated thousands of living systems with EGFP, including EGFP - expressing viruses and EGFP - expressing cancer cells.

However, this coupling does not exist in cell culture models with exogenously expressed c - MYC — the type of systems that are mainly used to investigate glutamine addiction in cancer.

In a mouse model of triple - negative breast cancer, mice injected with cancer cells that over-express ZMYND11 had tumor volumes of less than 50 cubic millimeters while control mice and those injected with cells expressing ZMYND11 deficient for binding to the methyl group had tumor volumes ranging from 150 to 400 cubic millimeters at eight weeks.

Cervical cancer cells expressing a wound - healing signal (green) in response to TRAIL stimulation.

In this study, researchers compared the effectiveness of the immunotherapy drug nivolumab (pronounced «nye VOL ue mab,» marketed at Opdivo), with standard - of - care chemotherapy in 541 patients with previously untreated or recurrent non-small cell lung cancer (NSCLC) that expressed PDL - 1 antibodieIn this study, researchers compared the effectiveness of the immunotherapy drug nivolumab (pronounced «nye VOL ue mab,» marketed at Opdivo), with standard - of - care chemotherapy in 541 patients with previously untreated or recurrent non-small cell lung cancer (NSCLC) that expressed PDL - 1 antibodiein 541 patients with previously untreated or recurrent non-small cell lung cancer (NSCLC) that expressed PDL - 1 antibodies.

Wellcome Trust Sanger Institute scientists and their collaborators have developed a new analysis tool that was able to show, for the first time, which genes were expressed by individual cells in different genetic versions of a benign blood cancer.

More importantly, the fibronectin part of the complex is expressed during a cell's transition to cancer and plays a role in cell growth, migration and differentiation.

This capability allowed the researchers to maneuver the nanospears in a lab dish to modify brain cancer cells so that they expressed a green fluorescent protein.

After being infused back into patients» bodies, these newly built cells both multiply and seek out a peptide expressed by the antigens NY - ESO - 1 and LAGE - 1 found in multiple myeloma cancer cells.

In one experiment, the researchers created arrays of mammary epithelial cells and asked how adding one or more cells expressing low levels of the cancer gene RasG12V affected the cells around them.

Next, the researchers tested the effects of RK - 33 and radiation in mice that had been injected with human prostate cancer cells that highly express DDX3.

What's more, the disrupted circadian oscillations in the MYC - expressing cancer cells could be partially rescued by inhibiting expression of REV - ERBα.

Ovarian cancer researchers have identified a protein biomarker expressed on the surface of tumour cells in high - grade serous ovarian cancer, the most common and lethal subtype of the disease.

Over the past two years, investigators from the Perelman School of Medicine at the University of Pennsylvania have reported results from a human trial in GBM using chimeric antigen receptor (CAR) T cell therapy, through which patients» own T cells were engineered to track down and kill cancer cells that express a tumor - specific protein known as EGFRvIII.

At the Dana - Farber Cancer Institute and the Broad Institute, for instance, Todd Golub, a specialist in the genetics of cancer, had spent a decade learning how to identify malignant tumors by the pattern of protein - coding messenger RNAs expressed in their Cancer Institute and the Broad Institute, for instance, Todd Golub, a specialist in the genetics of cancer, had spent a decade learning how to identify malignant tumors by the pattern of protein - coding messenger RNAs expressed in their cancer, had spent a decade learning how to identify malignant tumors by the pattern of protein - coding messenger RNAs expressed in their cells.

Neil Johnson's lab at the Fox Chase Cancer Center examined treatment resistance in breast cancer cells expressing the same BRCA1185delAG mutation and determined that the RING - deficient BRCA1 protein was also responsible for loss of sensitivity to certain types of cancer treatCancer Center examined treatment resistance in breast cancer cells expressing the same BRCA1185delAG mutation and determined that the RING - deficient BRCA1 protein was also responsible for loss of sensitivity to certain types of cancer treatcancer cells expressing the same BRCA1185delAG mutation and determined that the RING - deficient BRCA1 protein was also responsible for loss of sensitivity to certain types of cancer treatcancer treatments.

«There was some skepticism about whether a CD19 - directed therapy would work in this disease, since nearly all of these patients» cancerous plasma cells do not express CD19,» said the study's senior author, Edward Stadtmauer, MD, chief of Hematologic Malignancies and a professor of Hematology / Oncology in Penn's Abramson Cancer Center and Perelman School of Medicine.

«The study represents a clear breakthrough in precision medicine, as this molecule only kills the cancer cells that express the cancer - causing gene — not healthy cells.

In earlier research, Barbolina discovered that a fractalkine receptor — a protein found on the cell surface — is expressed in the majority of ovarian cancer caseIn earlier research, Barbolina discovered that a fractalkine receptor — a protein found on the cell surface — is expressed in the majority of ovarian cancer casein the majority of ovarian cancer cases.

The researchers identified a protein, SOCS3, that is highly expressed in normal cells but undetectable in triple - negative breast cancer.

In combination with a separate technique that measures the degree to which a gene is expressed, the researchers then identified genes that were either mutated or functionally altered through expression levels in these bladder cancer cell lineIn combination with a separate technique that measures the degree to which a gene is expressed, the researchers then identified genes that were either mutated or functionally altered through expression levels in these bladder cancer cell linein these bladder cancer cell lines.

According to the researcher Rosalva Rangel Corona, head of the project, the antitumor effect of interleukin in cervical cancer is because their cells express receptors for interleukin - 2 that «fit together» like puzzle pieces with the protein to activate an antitumor response.

These inhibitors effectively targeted and blocked Msi expressing cells, resulting in halted tumor growth in animal models as well as in patient - derived cancer cells, which harbor more complex mutations and are uniformly drug - resistant.

The goal of the first experiment was to see whether lncRNAs are differentially expressed in prostate cancer by measuring total RNA from prostate cancer cell lines and normal epithelial prostatic cells using NCode human ncRNA array and SurePrint G3 human lncRNA microarrays.

The more it's expressed only on cancer cells, the more targeted the therapy becomes,» says Colin Weekes, MD, PhD, CU Cancer Center investigator and assistant professor in the Division of Oncology at the CU School of Medcancer cells, the more targeted the therapy becomes,» says Colin Weekes, MD, PhD, CU Cancer Center investigator and assistant professor in the Division of Oncology at the CU School of MedCancer Center investigator and assistant professor in the Division of Oncology at the CU School of Medicine.

Previous evidence for a breast cancer link has been mixed — one study found increased risk in women exposed before age 14, whereas others found no association — but in a lab dish, DDT has been shown to activate the HER2 gene in human breast cells, which is expressed in some breast cancers.

When PDX1 is lost, the researchers found, it selects for cancer cells that express MYC, which is known to be involved in cancer growth and metastasis.

In a second study presented at the ESMO 2014 Congress, researchers report that about 20 % of patients with malignant pleural mesothelioma have cancer cells that express a protein called programmed cell - death ligand 1 (PD - L1) that is associated with poorer outcomes.

It was even more surprising to observe that in absence of Sox9, pre-cancerous cells disappear over time, suggesting that we can eliminate oncogene expressing cells before cancer formation» comments Jean - Christophe Larsimont, the first author of this study.

Strikingly, when miR - 940 was expressed in bone - resorbing breast cancer cells, the cells triggered bone - forming lesions in mice — behaving as though they were prostate cancer cells.

Cancer cells that have a relatively large number of mutations in their DNA express aberrant proteins — or neoantigens — that reveal the cancer to the immune sCancer cells that have a relatively large number of mutations in their DNA express aberrant proteins — or neoantigens — that reveal the cancer to the immune scancer to the immune system.

Using a new TaqMan PCR - based technique, the researchers screened a number of cancer cell lines from various tissues, and discovered that tRNA halves were specifically expressed in large quantities in sex hormone - dependent cancers, i.e., estrogen receptor (ER)- positive breast cancer and androgen receptor (AR)- positive prostate cancer that are driven by the hormones estrogen and testosterone.

However, another report found that miR - 7 expression correlated with poorer prognosis of breast cancer, and these apparently conflicting results suggest that miR - 7 may be differentially expressed in a specific cell population of breast cancer (26).

The mice they studied are engineered to express human leukocyte antigen, which helps regulate the human immune system, and, in this case, helped the mice produce the powerful T cells again human cancer.

They found that injecting into the carotid artery breast cancer cells that express markers allowing them to enter the brain — cells labelled with bioluminescent and fluorescent markers to enable tracking by imaging technologies — resulted in the formation of many metastatic tumors throughout the brain, mimicking what is seen in advanced breast cancer patients.

In the proposed project, Dr. Lampi Hermanson will produce NK cells from stem cells, inserting a chimeric antigen receptor (CAR) with the capacity to recognize mesothelin cells, which is expressed in 70 % of ovarian cancer patientIn the proposed project, Dr. Lampi Hermanson will produce NK cells from stem cells, inserting a chimeric antigen receptor (CAR) with the capacity to recognize mesothelin cells, which is expressed in 70 % of ovarian cancer patientin 70 % of ovarian cancer patients.

The example shown reveals that these estrogen agonists show the strongest connectivity to each other in MCF7, a human breast cancer cell line that expresses the estrogen receptor.