Paired SAGE - microarray expression data sets reveal antisense transcripts differentially
expressed in embryonic stem cell differentiation.
The creation of iPSCs began by studying proteins not only uniquely
expressed in embryonic stem cells, but proteins known to be functionally important in creating the unique properties of these cells.
Not exact matches
The team also found that ERAS, a tumorigenic gene
expressed in mouse
embryonic stem cells and iPSCs, was mutated and dysfunctional
in the mole - rat iPSCs.
Using a nuclear protein
expressed in follicle
stem cells (FSCs), the researchers found that castor, which plays an important role
in specifying which types of brain
cells are produced during
embryonic development, also helps maintain FSCs throughout the life of the animal.
Stem cell advocates have been expressing serious worry that ethical requirements spelled out in the draft guidelines — in particular, informed consent procedures for embryo donors — will rule out the use of many existing human embryonic stem cell lines, including the 21 lines approved under the Bush Administrat
Stem cell advocates have been
expressing serious worry that ethical requirements spelled out
in the draft guidelines —
in particular, informed consent procedures for embryo donors — will rule out the use of many existing human
embryonic stem cell lines, including the 21 lines approved under the Bush Administrat
stem cell lines, including the 21 lines approved under the Bush Administration.
We should not only question the construct of the «ethics of curing,» as I will show, but we also need to look critically at reservations toward research on
embryonic stem cells as they are
expressed in our society.
A large body of research has reported that Nanog is allelically regulated — that is, only one copy of the gene is
expressed at any given time — and fluctuations
in its expression are responsible for the differences seen
in individual
embryonic stem (ES)
cells» predilection to differentiate into more specialized
cells.
These are images of mouse
embryonic stem cells which grow
in a round colony of
cells (A) and
express Sox2 (B), shown
in red.
Whitehead Institute researchers have determined that the transcription factor Nanog, which plays a critical role
in the self - renewal of
embryonic stem cells, is
expressed in a manner similar to other pluripotency markers.
Mouse
embryonic stem cells injected into rat brains
express the AHD2 protein marker (yellow) characteristic of
cells lost
in Parkinson's disease.
But of course, posed this way the question does not distinguish between
stem cells obtained
in different ways (and indeed it is sensible to assume that those who
expressed opposition
in response to this question believed they were being asked about
embryonic stem cells, although the survey does not allow us to know that with confidence).
They made adult fibroblastic mouse
cells become essentially mouse
embryonic stem cells,
in appearance and function, by forcing the fibroblasts to
express four key
embryonic stem cell factors: Oct - 4, Sox2, Klf4, and c - Myc.
The scientists had strategically inserted these foreign DNA «markers» at particular points along the genome, next to genes
expressed only
in embryonic stem cells.