Sentences with phrase «expressed on cancer cells»

Stress - surveillance contributes to anti-neoplastic immunity through the activation, on lymphocytes, of the NKG2D receptor that recognizes ligands (NKG2D - L) expressed on cancer cells.

Not exact matches

«In addition, changes in how the genes are expressed (turned on or off) could be used in the future to predict how and when the cancer cells will spread to other parts of the body and how fast they will grow.»

One way cancer cells do this is by expressing a protein ligand that binds to a receptor on the T cells to prevent the T cell from recognizing and attacking the cancer cell.

«The antibody binds to a specific protein, called CD44s, which is expressed on the surface of pancreatic cancer stem cells.

They found that the number of copies of lncRNA genes on a chromosome consistently change in 12 different cancer types and lncRNA genes are widely expressed in cancer cells.

Ovarian cancer researchers have identified a protein biomarker expressed on the surface of tumour cells in high - grade serous ovarian cancer, the most common and lethal subtype of the disease.

Although myeloma is, like leukemias and lymphomas, a cancer involving white blood cells known as lymphocytes, myeloma cells don't traditionally express CD19 on their surface because they arise from the most mature type of lymphocytes — plasma cells.

T cells are collected from the patient's blood and genetically engineered to express cell - surface proteins called CARs, which recognize specific molecules found on the surface of cancer cells.

In earlier research, Barbolina discovered that a fractalkine receptor — a protein found on the cell surface — is expressed in the majority of ovarian cancer cases.

The more it's expressed only on cancer cells, the more targeted the therapy becomes,» says Colin Weekes, MD, PhD, CU Cancer Center investigator and assistant professor in the Division of Oncology at the CU School of Medcancer cells, the more targeted the therapy becomes,» says Colin Weekes, MD, PhD, CU Cancer Center investigator and assistant professor in the Division of Oncology at the CU School of MedCancer Center investigator and assistant professor in the Division of Oncology at the CU School of Medicine.

To devise a potential new therapy, the investigators engineered a population of neural stem cells to express a potent version of a gene called TRAIL, which codes for a molecule that activates cell - death - inducing receptors found only on the surface of cancer cells.

Blincyto (blinatumomab) is designed to treat cancers expressing a molecule called CD19 — found on the surface of B cell ALL and also non-Hodgkin's lymphoma.

Injections of iPSC - EPCs did not however have significant effect on tumor growth or on overall survival, but transducing cells with a baculovirus expressing CD40L, a member of the TNF gene family which can induce apoptosis [6, 7], and injection into the breast cancer lung metastasis, increased levels of pro-apoptotic cytokines in lung tissues, indicating the induction of apoptosis by CD40L carried by the EPCs (See figure).

Prostate cancer cells that express low levels of the protein give rise to cancer stem cells that are both hard to kill with existing drugs and highly capable of generating cancer cells on a large scale.

It would indeed be of great interest to see whether ablation of stromal p16Ink4a - expressing senescent cells, in otherwise genetically intact INK - ATTAC animals without existing tumors, would lower the animals» risk for cancer, and put any tumors they might develop on a less malevolent trajectory, than untreated mice.

Neoantigens — called so because they are newly formed during cancer development — may represent ideal immunotherapy targets as they are solely expressed on tumor cells.

We also found that the EphB4 receptor expressed on the surface of breast cancer cells can promote tumor xenograft growth by enhancing blood vessel formation through interactions with its preferred ligand, ephrin - B2, present in tumor endothelial cells.

Several gene rearrangements have been engineered and their protein products have been expressed in both normal cells and cancer cells to understand the effects of each rearrangement on cell function and targeted drug effectiveness.

The approach developed by the MGH team starts with the engineered protein, which in this case fuses an antibody fragment targeting a protein called mesothelin — expressed on the surface of such tumors as mesothelioma, ovarian cancer and pancreatic cancer — to a protein from the tuberculosis bacteria that stimulates the activity of dendritic and other immune cells.

Aptamers targeted mucin - 1 (MUC1), a glycosylated surface protein overexpressed on many cancers, including MCF7 breast cancer cells, and only minimally expressed in MCF - 10A non-cancerous cells.