Sentences with phrase «expressed on the cell surface»

The group was then able to sort the cells using markers expressed on the cell surface, to help pull out successfully edited cells for research, and eventually for therapeutic use.

However, this is unlikely given that the frequency of in - frame mutations remained stable over nearly four weeks in culture, that there was no significant increase in cell death between control cultures and those treated with X4 - ZFNs, and that the most common in - frame mutant was not expressed on the cell surface and thus can not maintain functionality.

Not exact matches

Here, cells expressing the interacting domains of v - and t - SNAREs on the cell surface were found to fuse spontaneously, demonstrating that SNAREs are sufficient to fuse biological membranes.

Previous studies have found that brown fat can be coaxed into action by activating the β3 - adrenergic receptor, which is expressed on the surfaces of brown and white fat cells, as well as on cells of the urinary bladder and other tissues.

Unlike CD8 + DCs that express the cell surface protein CD205, CD8 — DCs, which are positive for the 33D1 antigen, are specialized for presentation on major histocompatibility complex (MHC) class II.

«The antibody binds to a specific protein, called CD44s, which is expressed on the surface of pancreatic cancer stem cells.

pAPCs express toll - like receptors on their surfaces that recognize and trap molecular patterns called antigens on bacteria, food and our own cells.

For the study, Dr. Dadachova's team paired the monoclonal antibody (mAb2556) designed to target a protein expressed on the surface of HIV - infected cells with the radionuclide Bismuth - 213.

A radio - labeled human antibody binds to the viral gp41 protein expressed on the surface of the HIV - infected human lymphocyte and the cell is killed by alpha radiation delivered by the antibody.

In addition, exosomes are being co-opted as a treatment modality and have been modified through their parental cells to express a targeting moiety or marker tag on their surface.

S. mansoni IPSE binds to Immunoglobulin E (IgE), an antibody produced by the immune system that is expressed on the surface of basophils, a type of immune cell; and mast cells, another immune cell that mediates inflammation; and sequesters chemokines, signaling proteins that alert white cells to infection sites.

Ovarian cancer researchers have identified a protein biomarker expressed on the surface of tumour cells in high - grade serous ovarian cancer, the most common and lethal subtype of the disease.

Although myeloma is, like leukemias and lymphomas, a cancer involving white blood cells known as lymphocytes, myeloma cells don't traditionally express CD19 on their surface because they arise from the most mature type of lymphocytes — plasma cells.

T cells are collected from the patient's blood and genetically engineered to express cell - surface proteins called CARs, which recognize specific molecules found on the surface of cancer cells.

In earlier research, Barbolina discovered that a fractalkine receptor — a protein found on the cell surface — is expressed in the majority of ovarian cancer cases.

The explanation: Heat caused the HEV cells to express on their surface higher levels of two so - called «homing» molecules, ICAM - 1 and CCL21, which make lymphocytes tightly adhere to the HEV cells.

To devise a potential new therapy, the investigators engineered a population of neural stem cells to express a potent version of a gene called TRAIL, which codes for a molecule that activates cell - death - inducing receptors found only on the surface of cancer cells.

Those cells were then purified using the proteins they expressed on their surfaces.

Blincyto (blinatumomab) is designed to treat cancers expressing a molecule called CD19 — found on the surface of B cell ALL and also non-Hodgkin's lymphoma.

The mRNAs are delivered to the body and direct cells to produce and express both antigenic proteins on the cell surface, much like a native infection would do but without the ability to cause disease or spread.

There are no specific markers to identify them; however, they are negative for hematopoietic cell markers like CD34 / 45 / HLA - DR and express CD90 / 73/105 on their surface 2, 3, 4.

The gp160 is expressed on the surface of infected cells, an

This is a derivative of the TZM - bl cell line, engineered by lentiviral transduction to stably express human FcγRIIb on the surface.

This is a derivative of the TZM - bl cell line, engineered by lentiviral transduction to stably express human FcγRI on the surface.

The mRNA directs cells to produce and express the proteins on the cell surface, much like a native infections would do, but without the ability to cause disease.

This is a derivative of the TZM - bl cell line, engineered by lentiviral transduction to stably express human FcγRIIIa on the surface.

The vaccines deliver mRNA encoding for hemagglutinin to the body's cells, directing them to produce and express this viral antigenic protein transiently on the cell's surface, much like a native infection would do, but without the ability to cause disease.

High throughput injection of poly (A) + RNAs into Xenopus oocytes (in collaboration with Biopredic International) to obtain cells expressing molecules characteristic of certain cell types on their surface.

We also found that the EphB4 receptor expressed on the surface of breast cancer cells can promote tumor xenograft growth by enhancing blood vessel formation through interactions with its preferred ligand, ephrin - B2, present in tumor endothelial cells.

All of the parasites in their body are expressing the same var gene meaning their red blood cells all have the same PfEMP1 on their surface.

The approach developed by the MGH team starts with the engineered protein, which in this case fuses an antibody fragment targeting a protein called mesothelin — expressed on the surface of such tumors as mesothelioma, ovarian cancer and pancreatic cancer — to a protein from the tuberculosis bacteria that stimulates the activity of dendritic and other immune cells.

Their specialised killing abilities depend upon their cell surface receptor (T cell receptor, TCR) that recognises specific antigens expressed on their targets» cell surface.

In this study, we unexpectedly observed that SSEA3, a cell surface marker detected on the surface of pluripotent cells, is strongly expressed in a subpopulation of cells derived from a human dermal biopsy.

We derived a fibroblast line from a skin biopsy from a healthy adult male (HUF1)(Figure 1A) and used immunocytochemistry to characterize the expression of cell surface markers commonly expressed on pluripotent stem cells (Figure 1B, C and D).

The proteins displayed on the merozoite cell surface have long been considered attractive vaccine targets because of their direct exposure to host antibodies; however, progress in understanding the functional role of these targets has been hindered by technical challenges associated with expressing these proteins in a functionally active recombinant form.

The publication of the P. falciparum genome project in 2002 [10] identified the full complement of parasite proteins but progress in understanding the function of these proteins, including those displayed on the merozoite cell surface, has been hindered by the technical difficulties in expressing Plasmodium proteins in a functionally active form [11].

Aptamers targeted mucin - 1 (MUC1), a glycosylated surface protein overexpressed on many cancers, including MCF7 breast cancer cells, and only minimally expressed in MCF - 10A non-cancerous cells.

This loss of binding is often accompanied by a loss of ability to express (Barnwell et al. 1983; Handunetti et al. 1987; Gilks et al. 1990)-- or a major alteration in the level of expression of (David et al. 1983; Fandeur et al. 1995)-- the highly variable and clonally variant switching parasite antigens on the surface of the red cell known to be important for the maintenance of long - term chronic infections (Brown and Brown 1965).

Laminin - 511 is a major component of the basement membrane, which is expressed in early development of the embryo and can be used as a matrix for pluripotent (ES / iPS) stem cells, as it binds to integrin on cell surfaces.

Equipment / Features on this * Chevrolet Tahoe * Rear Axle 3.42 RatioWheels 4 - 17 X 7.5 (43.2 Cm X 19.1 Cm) Aluminum 5 - Spoke With Smooth Surface And Rectangular Pockets (Std) Tires P265 / 70R17 All - Season BlackwallLight Titanium / Dark Titanium Premium Cloth Seat TrimLt Preferred Equipment Group Includes Standard EquipmentSeats Front Bucket With (Ag1) 6 - Way Power Driver And (Ag2) Front Passenger Seat Adjusters Adjustable Head Restraints (Am1) Driver Manual Lumbar Control Floor Console And Rear Storage Pockets (Std) Summit WhiteAudio System Am / Fm Stereo With Mp3 Compatible Cd Player Seek - And - Scan Digital Clock Auto - Tone Control Radio Data System (Rds) Speed - Compensated Volume Theftlock And Auxiliary Audio Input Jack (Std) Transmission 6 - Speed Automatic Electronically Controlled With Overdrive And Tow / Haul Mode (Std) Engine Vortec 5.3 L V8 Sfi Flexfuel With Active Fuel Management Capable Of Running On Unleaded Or Up To 85 % Ethanol (With Gas - 320 Hp [238.6 Kw] @ 5200 Rpm 340 Lb - Ft Of Torque [459.0N - M] @ 4200 Rpm With E85 Ethanol - 326 Hp [243.1 Kw] @ 5300 Rpm 350 Lb - Ft Of Torque [472.5 N - M] @ 4400 Rpm) Iron Block (Std) Headliner ClothAssist Handles Front Passenger And Second Row OutboardSteering Wheel Leather - WrappedWindows Power With Driver Express - Down And Lockout FeaturesSteering Wheel Controls Mounted Audio And Cruise ControlsCruise Control Electronic With Set And Resume SpeedTheft - Deterrent System Vehicle Pass - Key IiiSeats Third Row 50/50 Split - Bench 3 - Passenger Removable All - Belts - To - SeatBluetooth For Phone Personal Cell Phone Connectivity To Vehicle Audio System And Hmi (Human Machine Interface) With Specific Steering Wheel ControlsSeat Adjuster Driver PowerFloor Covering Color - Keyed CarpetingPower Outlets 5 Auxiliary 12 - Volt Includes 2 On The Instrument Panel 1 In The Cargo Area 1 Inside The Center Console And 1 At The Back Of The Console.Floor Mats Color - Keyed Carpeted Front And Second Row RemovableLighting Interior With Dome Light Driver - And Passenger - Side Door Switch With Delayed Entry Feature Cargo Lights Door Handle Or Remote Keyless Entry - Activated Illuminated Entry And Map Lights In Front And Second Seat PositionsVisors Driver And Front Passenger Illuminated Vanity Mirrors Padded With Cloth Trim Extends On RodRemote Vehicle Starter Prep Package Includes Remote Keyless Entry (Remote Vehicle Starter Fob Available Through Gm Accessorieson this * Chevrolet Tahoe * Rear Axle 3.42 RatioWheels 4 - 17 X 7.5 (43.2 Cm X 19.1 Cm) Aluminum 5 - Spoke With Smooth Surface And Rectangular Pockets (Std) Tires P265 / 70R17 All - Season BlackwallLight Titanium / Dark Titanium Premium Cloth Seat TrimLt Preferred Equipment Group Includes Standard EquipmentSeats Front Bucket With (Ag1) 6 - Way Power Driver And (Ag2) Front Passenger Seat Adjusters Adjustable Head Restraints (Am1) Driver Manual Lumbar Control Floor Console And Rear Storage Pockets (Std) Summit WhiteAudio System Am / Fm Stereo With Mp3 Compatible Cd Player Seek - And - Scan Digital Clock Auto - Tone Control Radio Data System (Rds) Speed - Compensated Volume Theftlock And Auxiliary Audio Input Jack (Std) Transmission 6 - Speed Automatic Electronically Controlled With Overdrive And Tow / Haul Mode (Std) Engine Vortec 5.3 L V8 Sfi Flexfuel With Active Fuel Management Capable Of Running On Unleaded Or Up To 85 % Ethanol (With Gas - 320 Hp [238.6 Kw] @ 5200 Rpm 340 Lb - Ft Of Torque [459.0N - M] @ 4200 Rpm With E85 Ethanol - 326 Hp [243.1 Kw] @ 5300 Rpm 350 Lb - Ft Of Torque [472.5 N - M] @ 4400 Rpm) Iron Block (Std) Headliner ClothAssist Handles Front Passenger And Second Row OutboardSteering Wheel Leather - WrappedWindows Power With Driver Express - Down And Lockout FeaturesSteering Wheel Controls Mounted Audio And Cruise ControlsCruise Control Electronic With Set And Resume SpeedTheft - Deterrent System Vehicle Pass - Key IiiSeats Third Row 50/50 Split - Bench 3 - Passenger Removable All - Belts - To - SeatBluetooth For Phone Personal Cell Phone Connectivity To Vehicle Audio System And Hmi (Human Machine Interface) With Specific Steering Wheel ControlsSeat Adjuster Driver PowerFloor Covering Color - Keyed CarpetingPower Outlets 5 Auxiliary 12 - Volt Includes 2 On The Instrument Panel 1 In The Cargo Area 1 Inside The Center Console And 1 At The Back Of The Console.Floor Mats Color - Keyed Carpeted Front And Second Row RemovableLighting Interior With Dome Light Driver - And Passenger - Side Door Switch With Delayed Entry Feature Cargo Lights Door Handle Or Remote Keyless Entry - Activated Illuminated Entry And Map Lights In Front And Second Seat PositionsVisors Driver And Front Passenger Illuminated Vanity Mirrors Padded With Cloth Trim Extends On RodRemote Vehicle Starter Prep Package Includes Remote Keyless Entry (Remote Vehicle Starter Fob Available Through Gm AccessoriesOn Unleaded Or Up To 85 % Ethanol (With Gas - 320 Hp [238.6 Kw] @ 5200 Rpm 340 Lb - Ft Of Torque [459.0N - M] @ 4200 Rpm With E85 Ethanol - 326 Hp [243.1 Kw] @ 5300 Rpm 350 Lb - Ft Of Torque [472.5 N - M] @ 4400 Rpm) Iron Block (Std) Headliner ClothAssist Handles Front Passenger And Second Row OutboardSteering Wheel Leather - WrappedWindows Power With Driver Express - Down And Lockout FeaturesSteering Wheel Controls Mounted Audio And Cruise ControlsCruise Control Electronic With Set And Resume SpeedTheft - Deterrent System Vehicle Pass - Key IiiSeats Third Row 50/50 Split - Bench 3 - Passenger Removable All - Belts - To - SeatBluetooth For Phone Personal Cell Phone Connectivity To Vehicle Audio System And Hmi (Human Machine Interface) With Specific Steering Wheel ControlsSeat Adjuster Driver PowerFloor Covering Color - Keyed CarpetingPower Outlets 5 Auxiliary 12 - Volt Includes 2 On The Instrument Panel 1 In The Cargo Area 1 Inside The Center Console And 1 At The Back Of The Console.Floor Mats Color - Keyed Carpeted Front And Second Row RemovableLighting Interior With Dome Light Driver - And Passenger - Side Door Switch With Delayed Entry Feature Cargo Lights Door Handle Or Remote Keyless Entry - Activated Illuminated Entry And Map Lights In Front And Second Seat PositionsVisors Driver And Front Passenger Illuminated Vanity Mirrors Padded With Cloth Trim Extends On RodRemote Vehicle Starter Prep Package Includes Remote Keyless Entry (Remote Vehicle Starter Fob Available Through Gm AccessoriesOn The Instrument Panel 1 In The Cargo Area 1 Inside The Center Console And 1 At The Back Of The Console.Floor Mats Color - Keyed Carpeted Front And Second Row RemovableLighting Interior With Dome Light Driver - And Passenger - Side Door Switch With Delayed Entry Feature Cargo Lights Door Handle Or Remote Keyless Entry - Activated Illuminated Entry And Map Lights In Front And Second Seat PositionsVisors Driver And Front Passenger Illuminated Vanity Mirrors Padded With Cloth Trim Extends On RodRemote Vehicle Starter Prep Package Includes Remote Keyless Entry (Remote Vehicle Starter Fob Available Through Gm AccessoriesOn RodRemote Vehicle Starter Prep Package Includes Remote Keyless Entry (Remote Vehicle Starter Fob Available Through Gm Accessories.)