Sentences with phrase «expresses proteins designed»
Once activated, the circuit expresses proteins designed to direct the immune system to target the tumor cells, including surface T cell engagers, which direct T cells to kill the cells.
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The vaccine tested in Cape Town in 2013 was MVA 85A, a modification of the cowpox vaccine designed to express a major protein of the TB bacterium.
«We have shown that it is now possible to accurately design complex, multipass transmembrane proteins that can be expressed in cells.
Because the NPTX2 gene is not expressed in normal kidney tissue, a drug designed to target its protein would provide a highly focused treatment, Dr. Copland says.
For the study, Dr. Dadachova's team paired the monoclonal antibody (mAb2556) designed to target a protein expressed on the surface of HIV - infected cells with the radionuclide Bismuth - 213.
TSRI Research Associate Giordano de Guglielmo, who was the study's first author, spearheaded the experiment in rat models of alcohol dependence, which were designed to express a special protein to distinguish only the neurons activated by alcohol.
So, the researchers forced expression of a dominant - negative TGF - β receptor type 2 (DNRII) onto LMP - specific T cells (DNRII - LSTs) that were specially designed to seek out and destroy proteins derived from the Epstein - Barr virus expressed by the tumor cells.
The core will provide assistance with project design, testing of BioID - fusion proteins, establishment and testing of cells expressing BioID - fusion proteins, large scale BioID pull - downs, arranging for candidate identification by mass spectrometry and data analysis.