Sentences with phrase «expressing cells also»

Zhao, Chen and colleagues found that these gastrin - dependent peptide receptor - expressing cells also express a type of serotonin receptor known as the 1A receptor.

Not exact matches

The hair cells also expressed a green protein, showing they had taken up the gene.

The scientists also generated a panel of (reconstructed) ancestral and existing TRIM5 genes (19 total), expressed them in cultured cell lines, and exposed the cells to 16 different retroviruses (lentiviruses and others) to see which TRIM5 versions conferred resistance to which viruses.

Interestingly, two additional Nature papers released simultaneously with the Regev and Kuchroo team's study revealed that ILC2 cells in the gut also express Nmur1, take on an inflammatory state when exposed to NMU, and live in close proximity to NMU - producing nerve cells.

«Opioids have both analgesic and rewarding effects and they have these effects through mu opioid receptors and these receptors are expressed in pain terminals in the spinal cord and in areas of the brain that regulate pain but are also expressed in areas that regulate reward and a sense of pleasure,» Boyle said, referring to cells found in a person's central nervous system that bind to naturally occurring opioid compounds and reduce pain and make people feel much better.

The team also found that ERAS, a tumorigenic gene expressed in mouse embryonic stem cells and iPSCs, was mutated and dysfunctional in the mole - rat iPSCs.

The team reports that the adenomas grow from cells that express a gene called Lgr5 +, which is also active in normal intestinal stem cells.

Using a nuclear protein expressed in follicle stem cells (FSCs), the researchers found that castor, which plays an important role in specifying which types of brain cells are produced during embryonic development, also helps maintain FSCs throughout the life of the animal.

Lymphocytes in the grafts of undifferentiated iPS cells were also expressing relatively high levels of genes known to be involved in hostile immune responses.

Because the MS4A proteins are expressed on many cells in the body, the researchers will also test whether they detect cues that are generated by the body itself.

We should not only question the construct of the «ethics of curing,» as I will show, but we also need to look critically at reservations toward research on embryonic stem cells as they are expressed in our society.

One difference that is clear is that exhausted T cells express the programmed cell death protein - 1 (PD - 1), which commands them not to attack normal, healthy cells, but can also prevent them from striking at cancerous or chronically infected cells.

ALPL - expressing cells were also better at making cartilage or fat.

The new study revealed that pancreatic cancer cells not only send signals that make macrophages produce abnormal amounts of dectin - 1 surface receptors, but also that make tumor cells themselves express high levels of galectin - 9.

In the current study, Dr. Rudnicki and his team discovered that muscle stem cells also express the dystrophin protein, and without this protein, they produce ten-fold fewer muscle precursor cells, which in - turn generate fewer functional muscle fibres.

But Raz and colleagues have found that TPRV1 is also expressed by epithelial cells of the intestines, where it is activated by epidermal growth factor receptor or EGFR.

CAR - Ts also have their limitations; they target specific proteins, but not all cancer cells express these and some healthy ones may.

Neil Johnson's lab at the Fox Chase Cancer Center examined treatment resistance in breast cancer cells expressing the same BRCA1185delAG mutation and determined that the RING - deficient BRCA1 protein was also responsible for loss of sensitivity to certain types of cancer treatments.

They also expressed lower levels of an RNA message that controls the expression of a family of proteins called SOC, known to inhibit the migration of hematopoietic stem cells.

The elongated fibroblasts reprogrammed to become more T - cell - like in shape and hundreds of T - cell genes were also expressed in these skin cells.

This finding suggests that future studies should also consider the role mTOR - expressing oRG cells may play in the origins of these disorders.

As these cells rapidly proliferate, they also express high levels of an enzyme known as activation - induced cytidine deaminase (AID), which induces mutations in their DNA.

Knowing that Notch governs vessel permeability makes it a candidate for new drugs to treat cardiovascular diseases as well, and the team is also investigating the TMD as a potential therapeutic agent itself, as cell models that were exposed to leak - inducing inflammation displayed a dramatic reduction in leakage when they were engineered to express the TMD.

They also engineered the cells to express certain peptide molecules in their membranes, which acted like locks for streptavidin, ensuring the nanoparticles would bind to the cell membrane.

«Our work also suggests that cancer cells expressing high levels of BOK may be particularly sensitive to inhibitors that target the proteasome or the ERAD pathway.»

The circuit also expresses a checkpoint inhibitor designed to lift the brakes on T cell activity.

Some FGF2 - treated cells also expressed markers for the rhombic lip — the structure from which granule cells develop and migrate, and a marker specific to migrating granule precursors by week seven.

But researchers were surprised to also learn that a receptor protein (calcitonin receptor — Calcr) is expressed in the master clock cells of a mouse's brain.

The cells, which also expressed lower levels of genes involved in normal cellular metabolism, were evenly distributed throughout the liver's lobules.

Unlike OCT4, these genes can only be studied in human embryos because they are not expressed the same way, or at all, in mouse embryos or immortalized lines of human stem cells, says her colleague Robin Lovell - Badge, also at the Crick Institute.

An additional surprise was that the differentially expressed proteins were present not only in photoreceptor cells but also in other cells in the retina, including horizontal and Müller cells.

Interestingly, we found that at the protein level 2 efflux transporters, namely ABCB1 and ABCC10, were up - regulated and now are also expressed in germ cells, expression that was barely detectable, if at all, in controls.

Several tests in cultured cells indicated that ganciclovir would cause the death of HSV - TK - expressing stem cells, and testing in the mouse model confirmed that administration of the drug after successful treatment of brain metastases successfully eliminated therapeutic stem cells that also expressed HSV - TK.

The authors report that genes encoding heme synthetic enzymes (that generate porphyrin intermediates) are expressed in pigment cells, and the first three enzymes in the heme synthetic pathway are also required for proper pigmentation.

Blincyto (blinatumomab) is designed to treat cancers expressing a molecule called CD19 — found on the surface of B cell ALL and also non-Hodgkin's lymphoma.

Recently, several observations suggested that, besides monocyte - derived macrophages, dendritic cells, a distinct myeloid lineage, also express PPARγ at high levels.

MAIT cells are also activated by and kill epithelial cells expressing endogenous levels of MRI after infection with the invasive bacteria Shigella flexneri.

This interpretation predicts that transcripts expressed in the eye field should also be induced in EFTF - expressing pluripotent cells.

EFTF - expressing pluripotent cells form functional retinal cells and eyes when transplanted to the developing embryo, but can these induced retinal cells also differentiate into all the functional retinal cell classes in a mature normal or damaged retinal environment?

While both eye fields and EFTF - expressing pluripotent cells generated epidermis, forebrain, and olfactory tissue when grafted to the anterior neural plate, transplanted eye fields also formed muscle and head mesenchyme (Figure 4 and unpublished data).

Interestingly, in addition to the tissues formed by EFTF - expressing pluripotent cells, transplanted eye fields also formed muscle and head mesenchyme (Figure 4J and unpublished data).

YFP expressing cells are also observed in the surface ectoderm and left half of the forebrain (G).

We also cultured animals in BrdU and used immunocytochemistry to detect mitotically active cells in mature retinas generated from EFTF - expressing cells.

It was also reported that PPARγ is expressed in cells of monocyte origin such as macrophages and that it modulates the function of these cells.

In fact, it turned out that these cells expressed markers characteristic of brain pericytes, such as PDGF receptor beta, smooth muscle actin, NG2 and also CD146 not depicted here.

We have also identified a group of CD1c - restricted T cells that recognize a leukemia - associated lipid antigen and kill acute leukemia frequently expressing CD1c.

They were also enriched for genes expressed in leukemic stem cells of poor - prognosis AML.

Calretinin - expressing (likely bipolar) cells were also observed extending processes toward the peduncles of nearby layered photoreceptors (Figure 7C).

Experimental data have indicated that RyR1 is also expressed in some areas of the central nervous system, in some cell types of the immune system and in smooth muscle cells.

When T cells expressing LIGHT were introduced into the mice, lipid levels rose, both when the mice were fed a regular diet, and also when fed a high - fat, high - cholesterol diet.