Sentences with phrase «expressing cells better»
Following uptake into target cells, conjugates made with the PEG4Mal linker were processed to a cytotoxic metabolite that was retained by MDR1 - expressing cells better than a metabolite of similar conjugates prepared with the nonpolar linker N - succinimidyl - 4 -(maleimidomethyl) cyclohexane -1-carboxylate (SMCC).
http://cancerres.aacrjournals.org/ Not exact matches
You said, «Secondly, how do you know that god isn't making all these fetus's with the express intetion of giving their stem cells for the good of humanity?»
Immunophenotyping — a laboratory procedure used to study the proteins expressed by cells — is very commonly used in basic science research as well as in laboratory diagnostic testing.
«Opioids have both analgesic and rewarding effects and they have these effects through mu opioid receptors and these receptors are expressed in pain terminals in the spinal cord and in areas of the brain that regulate pain but are also expressed in areas that regulate reward and a sense of pleasure,» Boyle said, referring to cells found in a person's central nervous system that bind to naturally occurring opioid compounds and reduce pain and make people feel much better.
Previous studies have found that brown fat can be coaxed into action by activating the β3 - adrenergic receptor, which is expressed on the surfaces of brown and white fat cells, as well as on cells of the urinary bladder and other tissues.
To better understand how HMGA1 affected the rodents» intestines, Resar and Lingling Xian, M.D., Ph.D., research associate at the Johns Hopkins University School of Medicine, and their colleagues examined the transgenic animals» intestinal cells to determine which ones were expressing this gene.
These infrared fluorescent proteins are expressed well in mammalian cells and mice, and can be used for whole - body imaging.
The findings are consistent with previous studies suggesting that monoclonal antibodies in combination with chemotherapy work better in patients with EGFR expressing cells.»
With regard to taste, the findings will allow researchers to create a complete map of all the genes expressed in every type of taste cell within a taste bud, leading to a better understanding of how the taste system works.
ALPL - expressing cells were also better at making cartilage or fat.
The group employed various viral tracing methods — infecting receptor - expressing neurons with a virus strain and watching them spread as they label infected cells with a fluorescent protein — to visualize the neural circuit downstream of the ESP1 receptor, as well as providing an image of nerve fibers belonging to specific neurons in the brain and synapses relaying impulses from neuron to neuron, to map the anatomical foundation that conveys ESP1 signals in the brain.
At a symposium at The American Society of Human Genetics here last month, they reported zooming in on the genes expressed in a single brain cell, as well as panning out to understand how genes foster connections among far - flung brain regions.
Lastly, the team identified a gene, calretinin, in the hippocampal cells which was not expressed in the neocortical cells — suggesting the possibility that these cells exhibit different functional properties as well.
Although the amygdala's importance in face recognition and emotional assessment is well - known, little is understood about how these processes work, but research led by investigators at Cedars - Sinai and the California Institute of Technology has found that at least some of the brain cells that specialize in recognizing emotions may represent judgments based on the viewer's preconceptions rather than the true emotion being expressed.
Knowing that Notch governs vessel permeability makes it a candidate for new drugs to treat cardiovascular diseases as well, and the team is also investigating the TMD as a potential therapeutic agent itself, as cell models that were exposed to leak - inducing inflammation displayed a dramatic reduction in leakage when they were engineered to express the TMD.
These inhibitors effectively targeted and blocked Msi expressing cells, resulting in halted tumor growth in animal models as well as in patient - derived cancer cells, which harbor more complex mutations and are uniformly drug - resistant.
The authors uncover the cellular and molecular mechanisms, as well as the gene network regulated by Sox9 during the early steps of skin tumor initiation and demonstrates that Sox9 controls the long term maintenance and expansion of oncogene expressing cells by promoting self - renewing division and inhibiting differentiation.
Far better than any comb - over, the Hairless - expressing PK cells kept the mice furry, even after their first hairs fell out.
«Brain cancer cells are very good at evading the host immune system, because they do not express specific targets that can be recognized by immune cells,» said Liau, professor and vice chair of neurosurgery.
Pilot studies using a variety of strategies suggested that this goal could be best achieved by stimulating primary organ cell cultures with TNF - α (10 ng / ml) and targeting cells expressing the endothelial cell adhesion molecules E-selectin and VCAM - 1 through a FACS - driven strategy.
They play a pivotal role in regulating synaptic transmission, modulating excitotoxicity responsible for much of the neuronal damage caused by hypoxic insult in the brain [37], and are expressed in retinal photoreceptors, horizontal cells, and bipolar cells as well as the amacrine and ganglion cells of the inner retina [38 — 41].
The enhanced hiPS - HEP cells express PCSK9 and other genes that regulate blood cholesterol levels, as well as principal genes involved in uptake, synthesis, and beta - oxidation of fatty acids.
Albumin and α1AT are well - expressed in enhanced hiPS - HEP cells from all three hiPS cell lines (Figure 3, Panels A, B, and C), as shown by immunostaining and mRNA expression analysis.
Overgrown cultures stimulate quiescence, the resting phase of the cell cycle; quiescent cells do not take up nucleic acid or express transgenes as well as actively dividing cells resulting in lower lentiviral titers.
First, cells from Cellartis Human iPS Cell Line 22 (ChiPSC22) were modified to stably express AcGFP1, then these cells were cultured using the DEF ‑ CS culture system in a 48 - well plate.
Other genes relevant for regulating blood cholesterol levels are well - expressed in enhanced hiPS - HEP cells, e.g., apolipoprotein B (a VLDL), apolipoprotein A1 (an HDL), PCSK9, sterol regulatory element - binding proteins 1 and 2 (SREBP - 1 and -2), and lipoprotein lipase (LPL), which hydrolyzes triglycerides in lipoproteins into free fatty acids and glycerol.
In our experiments, both HNF4α and ASGPR1 are well - expressed in enhanced hiPS - HEP cells from all three hiPS cell lines (Figure 2), as shown by homogeneous nuclear staining for HNF4α and homogeneous membrane staining for ASGPR1.
A, Western blot analysis after subcellular fractionation showed that Karpas 299 and SU - DHL1 cells express phosphorylated mTOR, 4E - BP1, and rpS6 as well as total eIF4E predominantly in the cytoplasm.
The technique, which was used in this work to track how mRNA expresses itself in neuronal stem cells as they differentiate, could help us better understand neurogenesis and perhaps even be used to screen drugs for treating neurodegenerative diseases and brain trauma.
CD1d - restricted natural killer T (NK - T) cells that express an invariant Valpha14 TCRalpha chain have been implicated in microbial and tumour responses, as well as in auto - immunity.
The Mfrp - C1qtnf5 dicistronic message is expressed in the RPE cells and in the ciliary epithelium, as well as the lens, but not in photoreceptors.
I thought I could see GFP expression with a fluorescence microscope, but the GFP expression was so low (even in the transduced wild - type A549 cells that lack Cas9 and thus should have expressed GFP) that I couldn't get a good image.
We show that DONSON is expressed in progenitor cells of embryonic human brain and other proliferating tissues, is co-expressed with components of the DNA replication machinery, and that Donson is essential for early embryonic development in mice as well, suggesting an essential conserved role for DONSON in the cell cycle.
A strong immune response whereby DCs are activated and can express antigens, as well as secrete a number of inflammatory cytokines that lead to the activation of other immune cells, such as NK cells.
In support, PC3 cell holoclones, but not meroclones and paraclones, express three well - established stem and progenitor cell markers.
(F and G) The levels of LARP7 protein (F) and mRNA (G) as well as 7SK snRNA level (G) in control, shLARP7 - 2 cells and rescue cells (expressing an shRNA - resistant WT LARP7 cDNA) were examined by Western blotting and qRT - PCR, respectively.
Accordingly, P19 as well as a nuclear form of P19 expressed in Drosophila somatic cells were found to sequester TE - derived siRNAs whereas B2 predominantly bound their longer precursors.
Wheat Germ Oil: Expeller - expressed wheat germ oil is an excellent source of natural vitamin E, which is our best natural protection for the cell membrane.
The nutrients in healthy foods — vitamins, minerals, phytonutrients, botanicals — all work synergistically to help your cells express good health.
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«Scaria's barren cells, built to house the masses, express what the press information calls «the painful truth of modern existence» as well as «environmental destruction and [the] exploitation of natural resources.»