Sentences with phrase «expressing cells from»

To ensure that donor and host tissues could be easily distinguished, we generated EFTF - expressing cells from transgenic embryos constitutively expressing a variant of yellow fluorescent protein (Venus YFP)[10].

Not exact matches

If the reality at work is the inner creativity of God expressing himself as, among other things, the «low - level universals» of a multiplicity of «I's» or as expressing himself in the supposed subjectivity of psychicalized cells, how exactly does my present self - awareness derive from this?

One clear positive element in the stem - cell debate for me was hearing the top researchers in biomedical science reinforce The Catechism of the Catholic Church (CCC 343: «Man is the summit of the Creator's work, as the inspired account expresses by clearly distinguishing the creation of man from that of other creatures»).

9 years ago I had a basal cell carcinoma removed from my forehead, I had a 6 week old baby and was pretty terrified, especially after a number of consultants expressed complete shock that I had a BCC at the tender age of 27.

The protein expressed by the gene is thought to bind to serotonin receptor molecules and ferry them to the cell surface, positioning them to receive serotonin's signals from neighboring cells.

One way cancer cells do this is by expressing a protein ligand that binds to a receptor on the T cells to prevent the T cell from recognizing and attacking the cancer cell.

Previous research shows human induced pluripotent stem cells (hiPSCs)-- generated directly from adult cells — can express markers for a wide variety of cells, including those that secrete NP.

Thus, signals coming from a given neuron provide information about odors that activate the specific receptor protein expressed by that cell.

«We have been able to show that this protein is highly expressed in metastatic triple - negative breast cancer, and when we are depleting it from triple - negative breast cancer cells, we found that the cancer cells are not metastasizing,» Dr. Paul said.

Now, for the first time, scientists from Harvard Medical School have managed to «listen in» on the crosstalk between individual microbes and the entire cast of immune cells and genes expressed in the gut.

Bacteria expressing enzyme in one cell (bright green), while genetically identical cells do not, remaining protected from antibiotic onslaught; image courtesy of Yuichi Wakamoto / Neeraj Dhar / John McKinney Some strains of nasty bacterial infections, such as MRSA (methicillin - resistant Staphylococcus aureus), come loaded with resistance to antibiotics built right into their genes.

In a mouse model of triple - negative breast cancer, mice injected with cancer cells that over-express ZMYND11 had tumor volumes of less than 50 cubic millimeters while control mice and those injected with cells expressing ZMYND11 deficient for binding to the methyl group had tumor volumes ranging from 150 to 400 cubic millimeters at eight weeks.

Luster's team hopes to further investigate the characteristics of joints that underlie the critical role of C5a in initiating type III hypersensitivity and whether specific molecules expressed on endothelial cells lining joints play a role in transporting C5a and chemokines from the joint space into adjacent blood vessels.

«The views that are expressed there are very much different from researchers in stem cell work and reproductive medicine.»

When they deleted YY1 from male and female cells and compared genes that were differentially expressed on the X chromosome, they found 68 that were specific to females, one that was specific to males and 11 that were shared.

Researchers from the Eaton - Peabody Laboratories of the Massachusetts Eye and Ear and Harvard Medical School have created a new mouse model in which by expressing a gene in the inner ear hair cells — the sensory cells that detect sound and sense balance — protects the mice from age - related hearing loss (ARHL) and noise - induced hearing loss (NIHL), the two most common forms of deafness.

Functional glutamate receptor (GluRs) were transiently expressed in cultured mammalian cells from cloned complementary DNAs encoding GluR - A, - B, - C, or - D polypeptides.

The team reports that the adenomas grow from cells that express a gene called Lgr5 +, which is also active in normal intestinal stem cells.

«The genes that a taste cell expresses define essentially every aspect of that cell's behavior, from how it will respond to taste stimuli to how it will communicate with other cells,» said study co-leader Brian Lewandowski, PhD, a Monell physiologist.

The researchers then compared tumor cells isolated from multiple different breast cancer patients and found that cells expressing lower amounts of Numb - 1 and -2 were more resistant to the chemotherapy agent cisplatin.

Already, we see that cells from people with bipolar disorder are different in how often they express certain genes, how they differentiate into neurons, how they communicate, and how they respond to lithium,» says Sue O'Shea, Ph.D., the experienced U-M stem cell specialist who co-led the work.

If the miRNA recognition sequence binds to miRNA expressed in the desired cells, the expression of the regulatory protein is suppressed, thus distinguishing the cell type from others that do not contain the miRNA and express the protein.

«But what we've now shown is that RSV has an increased ability to cause airway obstruction because, during an RSV infection, the virus expresses a specific RSV - encoded non-structural protein, or NS2, in epithelial cells, causing the cells to shed from the airway lining and into the airway lumen.

Mammalian hairs and avian feathers develop from a similar primordial structure called a «placode»: a local thickening of the epidermis with columnar cells that reduce their rate of proliferation and express very specific genes.

One difference that is clear is that exhausted T cells express the programmed cell death protein - 1 (PD - 1), which commands them not to attack normal, healthy cells, but can also prevent them from striking at cancerous or chronically infected cells.

As a result, the H19 gene, which restricts growth, was no longer active while the Igf2 gene, which promotes cell division, was now expressed from both the paternal and the maternal allele.

The group employed various viral tracing methods — infecting receptor - expressing neurons with a virus strain and watching them spread as they label infected cells with a fluorescent protein — to visualize the neural circuit downstream of the ESP1 receptor, as well as providing an image of nerve fibers belonging to specific neurons in the brain and synapses relaying impulses from neuron to neuron, to map the anatomical foundation that conveys ESP1 signals in the brain.

Investigators found that autophagy plays a role in clearing IAPP from pancreatic beta cells using three experimental models: pancreatic beta cells, isolated pancreatic islets from mice that express the human form of IAPP, and human islets.

The pattern of which genes are expressed in a given cell is what distinguishes a neuron from, say, a liver cell.

In one study, geneticist Joseph Ecker at the Salk Institute in California took various stem cell lines reprogrammed from skin, fat, and other tissues and examined each line's genome for dna methylation, chemical marks that alter how genes are expressed.

Expressed in the membrane separating the cell from the outside, the neuron responded to blue light with excitation.

Thus, this cDNA derives from a gene (oct - 2) that specifies an octamer binding protein expressed preferentially in B lymphocytes, proving that, for at least one gene, a cell - specific transcription factor exists and its amount is controlled through messenger RNA availability.

Gauthier, Miller and co-workers engineered cells to express amino acid biosynthesis enzymes, which enabled cells to grow on their own supply of amino acids produced from supplemented precursors.

Over the past two years, investigators from the Perelman School of Medicine at the University of Pennsylvania have reported results from a human trial in GBM using chimeric antigen receptor (CAR) T cell therapy, through which patients» own T cells were engineered to track down and kill cancer cells that express a tumor - specific protein known as EGFRvIII.

Samantha de Silva and colleagues used a viral vector to express a light sensitive protein, melanopsin, in the residual retinal cells in mice which were blind from retinitis pigmentosa, the most common cause of blindness in young people.

While it is present on a number of different types of cells in the body, it is expressed at higher levels on metastatic tumour cells, including those which have spread from the lung.

In experiments on yeast cells expressing the mouse P - gp protein, 16 of the chemicals stopped it from working (Science Advances, doi.org/bd9b).

The widely accepted RNA - world theory posits that RNA — the molecule that today plays roles in coding, regulating, and expressing genes — elevated itself from the primordial soup of amino acids and cosmic chemicals, eventually to give rise first to short proteins called peptides and then to single - celled organisms.

They bred mice to express light - sensitive proteins in their acid - sensing TRCs, which make the cells fire in response to light from a laser.

Although myeloma is, like leukemias and lymphomas, a cancer involving white blood cells known as lymphocytes, myeloma cells don't traditionally express CD19 on their surface because they arise from the most mature type of lymphocytes — plasma cells.

T cells are collected from the patient's blood and genetically engineered to express cell - surface proteins called CARs, which recognize specific molecules found on the surface of cancer cells.

We first considered that this could be an experimental artifact, since it is common for developmental genes to be expressed only in a few specific cells, which could lead to the signals from the marks being diluted out and not detected.

Smolke's team coaxed the cells to express 21 genes in total, including many added from a diverse set of species (see graphic); making hydrocodone took 23 genes.

The goal of the first experiment was to see whether lncRNAs are differentially expressed in prostate cancer by measuring total RNA from prostate cancer cell lines and normal epithelial prostatic cells using NCode human ncRNA array and SurePrint G3 human lncRNA microarrays.

The point mutation was induced by forming a synthetic complex through removal of nuclease activity from the CRISPR system — a technique using artificial nuclease — and addition of deaminase, a deaminizing (base - modifying) enzyme, and then expressing it in yeasts and mammalian cells.

First, the research team succeeded in efficiently inducing inner ear cells expressing inner ear specific proteins, such as CONNEXIN 26, CONNEXIN 30, and PENDRIN, from human iPS cells.

The fact that these stem cells express fewer metabolic genes might be one way to protect the cells from the daily grind faced by their peers, and to limit the production of metabolic byproducts that can damage DNA.

Some FGF2 - treated cells also expressed markers for the rhombic lip — the structure from which granule cells develop and migrate, and a marker specific to migrating granule precursors by week seven.

One way of thinking about what differentiates a breast cell from a heart cell is that each cell type expresses different subsets of genes.

A human - specific gene expressed only in glial cells of the brain apparently arose from conversion of the ancestral gene by a nonfunctional pseudogene in a common human chimp ancestor.