Sentences with phrase «expressing cells in the tissue»

Presence of CD8 + T cells in the ectocervical mucosa correlates with genital viral shedding in HIV - infected women despite a low prevalence of HIV RNA - expressing cells in the tissue.

Not exact matches

The scientists have shown that, in all cancers, a sort of «identity crisis» is observed in cancerous cells: in the organs or tissues in which a tumor develops, genes specific to other tissues or to other stages of the development of the organism express themselves in an aberrant manner.

Of these, connective tissue growth factor a (ctgfa) was expressed in glial cells during a key period of healing, as the cells were actively building bridges across damaged tissue.

In healthy breast tissue, the percentage of cells expressing molecular marker Ki67 (green) and p27 (red) was low.

However, two types of cells in the olfactory epithelium (specialized tissue responsible for sense of smell), are mixed together and form a mosaic pattern despite expressing different types of cadherins.

In this study, using a mouse transgenic approach, the scientists demonstrated that ILC2s express a checkpoint molecule, known as «PD - L1», that functions to control the expansion of allergy - inducing Th2 cells and the development of allergic pulmonary and gut tissue inflammation.

In one study, geneticist Joseph Ecker at the Salk Institute in California took various stem cell lines reprogrammed from skin, fat, and other tissues and examined each line's genome for dna methylation, chemical marks that alter how genes are expresseIn one study, geneticist Joseph Ecker at the Salk Institute in California took various stem cell lines reprogrammed from skin, fat, and other tissues and examined each line's genome for dna methylation, chemical marks that alter how genes are expressein California took various stem cell lines reprogrammed from skin, fat, and other tissues and examined each line's genome for dna methylation, chemical marks that alter how genes are expressed.

A new technique for sequencing the RNA in a single cell has been revolutionary, Ngai said, allowing researchers to trace which stem cells in a densely packed tissue become specialized, based on the mRNA present in the cell, which indicates which genes are being expressed.

«The vitamin D receptor is expressed in insulin - secreting pancreatic beta cells and in peripheral target tissues such as skeletal muscle and adipose tissue.

These differently expressed microRNAs may contribute to stem cell and epithelial (tissue cells) abnormalities in diabetic corneas.

Neuronal cells express a pp60c - src variant that displays an altered electrophoretic mobility and a different V8 peptide pattern relative to pp60c - src expressed in tissues of non-neuronal origin.

Using a new TaqMan PCR - based technique, the researchers screened a number of cancer cell lines from various tissues, and discovered that tRNA halves were specifically expressed in large quantities in sex hormone - dependent cancers, i.e., estrogen receptor (ER)- positive breast cancer and androgen receptor (AR)- positive prostate cancer that are driven by the hormones estrogen and testosterone.

The same procedure was used to measure the fraction of CD68 - expressing cells in human tissues.

Myriad control switches help to arbitrate how genes get expressed in different cells and tissues, and those switches are often triggered by maternal diet, toxic exposures and many other environmental factors.

We calculated the average adipocyte cross-sectional area and the percentage of F4 / 80 - expressing cells in the perigonadal, perirenal, mesenteric, and subcutaneous inguinal adipose tissue depots from Ay / + female, Lepob / ob female, lean male, and diet - induced obese (DIO) male mice.

In muscle tissue, we observed only rare F4 / 80 - expressing cells between myofibrils.

To determine whether adipose tissue macrophages express any molecules implicated in obesity - associated complications, we isolated three cell populations from the parametrial adipose tissue of three obese B6.V Lepob / ob mice: (a) an adipocyte - enriched population, (b) a stromal vascular macrophage F4 / 80 + population, and (c) an F4 / 80 — stromal vascular population.

These genes are expressed in many tumors and are silent in normal tissues except male germline cells.

Interestingly, in addition to the tissues formed by EFTF - expressing pluripotent cells, transplanted eye fields also formed muscle and head mesenchyme (Figure 4J and unpublished data).

Being stably and constitutively expressed at high levels in most tissues and cells, GAPDH is considered a housekeeping protein.

GCSF and hypoxia inducible factor - 1α (HIF - 1α) have been shown to up - regulate SDF - 1α in the infarcted area in a rabbit ischemia model and promote the migration of CXCR4 expressing cells towards cardiac tissues [47 - 49].

Was then expressed as a whole antibody in CHO cells in tissue culture.

In addition, the organs and tissues that possess high levels of SDF - 1, such as liver, lung, bone marrow, and lymph nodes, attract the migration of CXCR4 - expressing cancer cells [22].

Tissue factor expressed by circulating cancer cell - derived microparticles drastically increases the incidence of deep vein thrombosis in mice.

Injections of iPSC - EPCs did not however have significant effect on tumor growth or on overall survival, but transducing cells with a baculovirus expressing CD40L, a member of the TNF gene family which can induce apoptosis [6, 7], and injection into the breast cancer lung metastasis, increased levels of pro-apoptotic cytokines in lung tissues, indicating the induction of apoptosis by CD40L carried by the EPCs (See figure).

On the other hand, there are many other tissues — notably, the kidney and articular cartilage — where p16Ink4a - expressing senescent cells appear to be a contributing factor to human and murine degenerative aging, but which were not evaluated in treated or control mice in this study, and it would be of interest to see the effects of ablation of p16Ink4a - positive senescent cells.

To impute aging phenotypes directly to p16Ink4a - expressing senescent cells, van Deursen and colleagues with expertise in the aging and senescence of the relevant tissues developed and tested the effects of a pharmacologically - inducible system for the ablation of p16Ink4a - expressing cells.

Expression of the familial PD - linked A53T or A30P mutant ASs in cell models results in an increased proportion of CTTAS being produced than is the case when expressing the WT protein; consistent with this, a higher proportion of the total soluble AS in human brain tissue with AS neuropathology is CTTAS, and a higher proportion yet of the total AS in insoluble AS deposits.

As the investigators note, the rapid age - related arterial stiffening and cardiac arrhythmias that appear to be at cause for the majority of deaths in BubR1H / H mice were not attenuated by ablating p16Ink4a - expressing senescent cells — but these tissues had little burden of such cells, so this finding reinforces the conclusion that the multiple aging phenotypes arrested in these mice when senescent cells were ablated is attributable specifically to the removal of their baleful influence on local tissues.

We are using a new technique, called single cell RNA sequencing, to isolate thousands of single neurons from human brain tissue, study all the genes that are expressed in each individual cell, and make cell - to - cell comparisons between normal, early stage and late stage AD.

A strain of rock pigeons that express Cas9 in every cell could improve the efficiency of subgerminal cavity injections because half of the CRISPR / Cas9 system would already be functioning in the embryo's tissues.

(B) In situ hybridization reveals Lcn16 is expressed in glandular tissue of the VNO and (C) Lcn17 is expressed in cells within the main olfactory epitheliuIn situ hybridization reveals Lcn16 is expressed in glandular tissue of the VNO and (C) Lcn17 is expressed in cells within the main olfactory epitheliuin glandular tissue of the VNO and (C) Lcn17 is expressed in cells within the main olfactory epitheliuin cells within the main olfactory epithelium.

With regard to the meiotic germ cell markers, SCP1 and SCP3 expression was also detected in the testes, whereas MLH1 was expressed in various tissues and ES cells.

The team observed that approximately 15 percent of the proteins exhibited single - cell variation: In a tissue that looked superficially uniform, some cells might differ from their neighbors in the amount or spatial distribution of the proteins they expressed, when one would expect them to be the samIn a tissue that looked superficially uniform, some cells might differ from their neighbors in the amount or spatial distribution of the proteins they expressed, when one would expect them to be the samin the amount or spatial distribution of the proteins they expressed, when one would expect them to be the same.

In tissues — such as adipose tissue, skeletal muscle and eye — in which p16 (Ink4a) contributes to the acquisition of age - related pathologies, life - long removal of p16 (Ink4a)- expressing cells delayed onset of these phenotypeIn tissues — such as adipose tissue, skeletal muscle and eye — in which p16 (Ink4a) contributes to the acquisition of age - related pathologies, life - long removal of p16 (Ink4a)- expressing cells delayed onset of these phenotypein which p16 (Ink4a) contributes to the acquisition of age - related pathologies, life - long removal of p16 (Ink4a)- expressing cells delayed onset of these phenotypes.

The tissue was modified in the lab to express nerve growth factor (NGF), a naturally occurring protein that prevents cell death and stimulates cell function.

Although none of the genes were exclusively expressed in the annelid mesodermal midline, their combined coexpression was unique to these cells (implying that mesodermal midline in annelids and chordamesoderm in vertebrates are more similar to each other than to any other tissue).

Cells within the site of inflammation, the synovial tissue, in rheumatoid arthritis patients seem to still actively synthesise the active vitamin D3 derivative and express the receptor.

We show that DONSON is expressed in progenitor cells of embryonic human brain and other proliferating tissues, is co-expressed with components of the DNA replication machinery, and that Donson is essential for early embryonic development in mice as well, suggesting an essential conserved role for DONSON in the cell cycle.

Treatment of Type 1 Diabetes With Adipose Tissue — Derived Stem Cells Expressing Pancreatic Duodenal Homeobox 1 (December 2009) in Stem Cells and Development.

For quantifying the performance of Amrose in deep tissue optical imaging experiments, DT40 cells expressing no FP (control), Amrose v1 and mRaspberry were used.

Some receptors display a broad pattern of expression across tumour types, while others were expressed in cell lines from a particular tissue.

It is expressed in tissue progenitor cells and plays a role in embryogenesis.

In normal mammary tissues, LARP7 was highly expressed in the epithelial cells of the mammary lobuli and terminal ducts (Figure 1CIn normal mammary tissues, LARP7 was highly expressed in the epithelial cells of the mammary lobuli and terminal ducts (Figure 1Cin the epithelial cells of the mammary lobuli and terminal ducts (Figure 1C).

Bioelectrical impedance vector analysis (BIVA) expresses tissue hydration status and body cell mass solely while considering the impedance vector relative to a population of healthy individuals (24); this was a valid method for detecting changes in hydration (classified as under -, normal or overhydration) and body fluid volume changes (25).