Sentences with phrase «expressing cells into»

We showed previously that myostatin circulates in the blood and that systemic effects can be achieved by implanting myostatin - expressing cells into a single site in the lower limb [21]; however, there have been no experiments that have demonstrated conclusively that myostatin normally acts systemically.

Not exact matches

Hoylman supports the campaign to remake Fifth and Sixth Avenues into complete streets, backs the MoveNY fair - tolling plan, and has expressed interest in introducing legislation that would make it easier for law enforcement to secure cell phone records after vehicular crashes.

Because the human cells had been genetically engineered to express green fluorescent protein, the tiny blobs showed up in brilliant lime through the transparent window that the scientists glued into the mice's skull.

Previous studies have found that brown fat can be coaxed into action by activating the β3 - adrenergic receptor, which is expressed on the surfaces of brown and white fat cells, as well as on cells of the urinary bladder and other tissues.

Published in the February 27 issue of Cell, the study found that tumor cells that reach the brain — and successfully grow into new tumors — hug capillaries and express specific proteins that overcome the brain's natural defense against metastatic invasion.

«With Rudolph,» Farber says, «the coral DNA got inserted into a gene that is normally expressed in the nasal epithelial cells, the cells of his nose.

Bacteria expressing enzyme in one cell (bright green), while genetically identical cells do not, remaining protected from antibiotic onslaught; image courtesy of Yuichi Wakamoto / Neeraj Dhar / John McKinney Some strains of nasty bacterial infections, such as MRSA (methicillin - resistant Staphylococcus aureus), come loaded with resistance to antibiotics built right into their genes.

In 1994, scientists first realized that putting the EGFP gene into cells made them glow green, making it possible to easily visualize them: ever since, scientists have generated thousands of living systems with EGFP, including EGFP - expressing viruses and EGFP - expressing cancer cells.

Scientists are hopeful that ultimately these cells could be transformed in the laboratory to yield specific cell types needed for a particular treatment, or to cross the «blood - brain barrier» by expressing specific therapeutic agents that are released directly into the brain.

Luster's team hopes to further investigate the characteristics of joints that underlie the critical role of C5a in initiating type III hypersensitivity and whether specific molecules expressed on endothelial cells lining joints play a role in transporting C5a and chemokines from the joint space into adjacent blood vessels.

The enzyme has the novel ability to convert a chemical, metronidazole, into a toxin, which allows researchers to selectively kill the cells expressing it.

They found that infection of the narrowest airways of the lung by PIV3 alone caused moderate levels of inflammation, but after infection by PIV3 expressing RSV NS2, the epithelial cells lining the narrow airways were shed rapidly into the airway lumen.

Already, we see that cells from people with bipolar disorder are different in how often they express certain genes, how they differentiate into neurons, how they communicate, and how they respond to lithium,» says Sue O'Shea, Ph.D., the experienced U-M stem cell specialist who co-led the work.

Kotton built a reporter gene that glowed green when the stem cells first expressed Nkx2 - 1, and Hawkins engineered the same gene into human cells.

«But what we've now shown is that RSV has an increased ability to cause airway obstruction because, during an RSV infection, the virus expresses a specific RSV - encoded non-structural protein, or NS2, in epithelial cells, causing the cells to shed from the airway lining and into the airway lumen.

In addition, exhausted CD8 T cells start to express inhibitory cell surface receptors that receive and feed inhibitory signals into the cell establishing a negative feedback loop.

After being infused back into patients» bodies, these newly built cells both multiply and seek out a peptide expressed by the antigens NY - ESO - 1 and LAGE - 1 found in multiple myeloma cancer cells.

When this clone was inserted into a mammalian expression vector and transfected into COS - 7 cells, a protein that specifically phosphorylated the agonist - occupied form of the beta 2 - adrenergic receptor and phosphorylated, much more weakly, the light - bleached form of rhodopsin was expressed.

A large body of research has reported that Nanog is allelically regulated — that is, only one copy of the gene is expressed at any given time — and fluctuations in its expression are responsible for the differences seen in individual embryonic stem (ES) cells» predilection to differentiate into more specialized cells.

The team went on to show that supplementing heavy stable isotope - labeled forms of these precursors led to incorporation of heavy amino acids into proteins produced in enzyme expressing cells.

«Sumudu has shown that liver cells that express high levels of the IFITM proteins are resistant to infection with the hepatitis C virus by blocking entry of the virus into the cells,» Associate Professor Beard says.

These cells express many of the same genes expressed in brain cells — potentially providing a window into genetically - influenced differences in molecular responses to sex hormones.

Mouse embryonic stem cells injected into rat brains express the AHD2 protein marker (yellow) characteristic of cells lost in Parkinson's disease.

Many cells lit up, and when the researchers took a closer look, they found that L1 jumped into several genes typically expressed by neurons.

To test the theory, Arlinghaus and colleagues first demonstrated that BCR - ABL positive cells expressed 24p3 and secreted it into the surrounding tissue, causing cell death.

«When implanted into the tibia or onto the skull of mice, moreover, we discovered that cells expressing miR - 940 can induce the kind of osteoblastic lesions that are typical of prostate cancer.»

Once iPS cells have differentiated into the desired tissue type, they may not express the problematic genes, he notes.

These mutations are inserted into batches of yeast or bacterial cells, which express the altered gene and produce millions of random protein variants.

But a team of Swiss scientists has engineered cells that come pretty close: Only when they are bathed in blue light do the cells express a gene that has been inserted into them.

They hypothesized that expressing NeuroD1 protein into the reactive glial cells at the injury site might help to generate new neurons — just as it does in the hippocampus.

Injecting the TRAIL - expressing stem cells into the carotid artery, a likely strategy for clinical application, led to significantly slower tumor growth and increased survival, compared with animals receiving unaltered stem cells or control injections.

To test whether adipose tissue F4 / 80 + cells shared a common bone marrow origin with other tissue macrophage populations, we transplanted bone marrow from C57BL / 6J mice expressing the CD45.1 leukocyte marker into 6 - week - old lethally irradiated C57BL / 6J mice expressing the CD45.2 leukocyte marker.

The genes are likely to be expressed when cells differentiate into neural crest lineages, such as neurons or Schwann cells, thereby enabling researchers to study the disease in a dish.

However, type III cells do not express the vesicular nucleotide transporter VNUT, which is reportedly required to load ATP into vesicles (Iwatsuki et al., 2009), and ATP release has not been detected from type III cells, so the source of ATP with sour stimulation is unclear (Huang et al., 2007; Romanov et al., 2007).

Importantly, intraperitoneal inoculation of pancreatic homogenates containing IAPP aggregates into transgenic mice expressing human IAPP dramatically accelerates IAPP amyloid deposition, which was accompanied by clinical abnormalities typical of T2D, including hyperglycemia, impaired glucose tolerance, and a substantial reduction on β cell number and mass.

They found that injecting into the carotid artery breast cancer cells that express markers allowing them to enter the brain — cells labelled with bioluminescent and fluorescent markers to enable tracking by imaging technologies — resulted in the formation of many metastatic tumors throughout the brain, mimicking what is seen in advanced breast cancer patients.

By 3 to 7 days, these cells differentiated into myofibroblasts that secreted abundant extracellular matrix proteins and expressed smooth muscle α - actin to structurally support the necrotic area.

EFTF - expressing pluripotent cells form functional retinal cells and eyes when transplanted to the developing embryo, but can these induced retinal cells also differentiate into all the functional retinal cell classes in a mature normal or damaged retinal environment?

Mesenchymal stem cells express a surface protein called α4β1 integrin as they turn into osteoblasts.

«But there are many different genes that could be involved: some control the virus's ability to enter immune cells, others control how the virus tricks cells into expressing its genes.

«Our data suggests that human tumors can be divided into two major subtypes, the let - 7hi and let - 7lo - expressing tumor cells,» the authors write.

When transplanted to the subretinal space of mice lacking functional photoreceptors, human embryonic stem cells directed toward a retinal lineage integrate into the outer nuclear layer, express photoreceptor markers, and restore a light response as determined by the electroretinogram (ERG)[5].

TNA3: BPRC will offer access to its library of human cell reporter assays for the identification of innate immune receptor - induced signalling cascades, including human cell lines transfected with PAMPs such as TLR and / or engineered to express luciferase in response to NF - kB or IFRE - mediated signal transduction, and cell lines that provide insight into the intracellular signalling cascades of innate immune receptors.

Perivascular cells, including pericytes in the smallest blood vessels (e.g., microvessels) and ARCs around larger ones, express mesenchymal stem cell markers and bear a multi-differentiation fate potential (differentiate into osteoblasts, chondrocytes, adipocytes, smooth muscle cells and myocytes) similar to that documented for MSCs in vitro.

These results suggest that EFTF - expressing cells are multipotent, as they differentiate into the seven retinal cell classes of the mature retina.

However, when forced to express the eye field transcription factor (EFTF) genes, the cells differentiate into all seven retinal cell classes and eventually organize themselves into a functioning eye that can detect light and guide tadpoles in a vision - based behavior.

To convert the fibroblasts into muscle cells, the researchers transfected the fibroblasts with the cDNA of MyoD, forcing the cells to express MyoD (Davis et al., 1987).

He accomplished that with the help of a virus different from the retroviruses used initially: an adenovirus that brings the genes into a cell's nuclear area but doesn't become part of the cell's DNA; it disappears after it expresses the reprogramming genes.

When T cells expressing LIGHT were introduced into the mice, lipid levels rose, both when the mice were fed a regular diet, and also when fed a high - fat, high - cholesterol diet.

In addition, the data showed that the gut's hormone - producing enteroendocrine cells (EECs)-- long divided into subsets based on the idea that each only expressed a single hormone — can actually express multiple hormones at once.