Sentences with phrase «expressing fibroblast»

Kraman, M. and Bambrough, P. J. and Arnold, J. N. and Roberts, E. W. and Magiera, L. and Jones, J. O. and Gopinathan, A. and Tuveson, D. A. and Fearon, D. T. (2010) Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein - alpha.

Roberts, E. W. and Deonarine, A. and Jones, J. O. and Denton, A. E. and Feig, C. and Lyons, S. K. and Espeli, M. and Kraman, M. and McKenna, B. and Wells, R. J. B. and Zhao, Q. and Caballero, O. L. and Larder, R. and Coll, A. P. and O'Rahilly, S. and Brindle, K. M. and Teichmann, S. A. and Tuveson, D. A. and Fearon, D. T. (2013) Depletion of stromal cells expressing fibroblast activation protein - alpha from skeletal muscle and bone marrow results in cachexia and anemia.

Not exact matches

A team led by Byeong - Chun Lee of Seoul National University in South Korea created the dogs by cloning fibroblast cells that express a red fluorescent gene produced by sea anemones.

When human orbital fibroblasts from TED patient tissue were compared to tissue from patients without TED, the researchers discovered that TED orbital fibroblasts expressed higher levels of AHRs than non-TED orbital fibroblasts.

Fibroblasts (red) express endothelial markers (green), making the heart cells in mice appear yellow.

To explore this idea, they induced heart attacks in mice and then studied the fibroblasts to see if the cells expressed markers characteristic of endothelial cells.

To their surprise, almost a third of the fibroblasts in the area of the cardiac injury expressed these endothelial markers.

Their hypothesis was that the possible genes responsible for the pro-tumour role of the CAFs would be expressed at high levels only in these fibroblasts, and not in fibroblasts of the healthy tissue.

The elongated fibroblasts reprogrammed to become more T - cell - like in shape and hundreds of T - cell genes were also expressed in these skin cells.

To convert the fibroblasts into muscle cells, the researchers transfected the fibroblasts with the cDNA of MyoD, forcing the cells to express MyoD (Davis et al., 1987).

The α3, α4, and α7 nAChR subunits were expressed in cerebellar cells but not in kidney fibroblasts.

Yamanaka's group used human adult dermal fibroblasts and induced them to become iPSCs, appearing and functioning like hESCs, by having them express the same proteins as he used with mouse cells: Oct - 4, Sox2, Klf4, and c - Myc (Takahashi et al., 2007).

They made adult fibroblastic mouse cells become essentially mouse embryonic stem cells, in appearance and function, by forcing the fibroblasts to express four key embryonic stem cell factors: Oct - 4, Sox2, Klf4, and c - Myc.

(6) Moreover, subcutaneous adipose of prematurely - aged transgenic mice exhibited high levels of staining for the senescence marker senescence - associated - β - galactosidase (SAβ - gal) and expressed high levels of several established markers of senescence, including p21, p19, interleukin - 6, (insulin - like growth factor binding protein - 2 (Igfbp2), and Pai - 1; primary BubR1H / H; INK - ATTAC mouse embryonic fibroblasts forced artificially into senescence by oncogenic Ras or serial passage exhibited a subpopulation that was both GFP + and stained positively SAβ - gal.

«In cells that don't produce antibodies, like fibroblasts or T - cells, these antibody genes are attached to the inner nuclear membrane and are not recombined or expressed,» said Singh.

In renal fibroblast cultures, however, mRNAs of the α3, α4, and α7 nAChR subunits were not expressed.

Feig, C. and Jones, J. O. and Kraman, M. and Wells, R. J. B. and Deonarine, A. and Chan, D. S. and Connell, C. M. and Roberts, E. W. and Zhao, Q. and Caballero, O. L. and Teichmann, S. A. and Janowitz, T. and Jodrell, D. I. and Tuveson, D. A. and Fearon, D. T. (2013) Targeting CXCL12 from FAP - expressing carcinoma - associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer.

Remarkably, a combination of just three of the factors (Gata4, Mef2c, and Tbx5) was enough to efficiently convert fibroblasts into cells that could beat like cardiomyocytes and turned on most of the same genes expressed in cardiomyocytes.

From early passages (P2) to late passages (P31), they displayed homogeneous fibroblastic morphology and expressed VIMENTIN, which is considered as a fibroblast marker.

Five beagles were created by cloning fibroblast cells that express a red florescent gene produced by sea anemones.

We hypothesize that SSEA3 expression is either identifying another less differentiated and / or tissue specific stem cell like population that is retrieved with the donor skin biopsy or that with culture, a subpopulation of fibroblasts may acquire the ability to express SSEA3.

Mouse fibroblast cells expressing HP1alpha, the human version of heterochromatin protein 1a.

We derived a fibroblast line from a skin biopsy from a healthy adult male (HUF1)(Figure 1A) and used immunocytochemistry to characterize the expression of cell surface markers commonly expressed on pluripotent stem cells (Figure 1B, C and D).

Fibroblasts that expressed SSEA3 demonstrated an enhanced iPSC generation efficiency, while no iPSC derivation was obtained from the fibroblasts that did not expFibroblasts that expressed SSEA3 demonstrated an enhanced iPSC generation efficiency, while no iPSC derivation was obtained from the fibroblasts that did not expfibroblasts that did not express SSEA3.

Additionally, a 10-fold enrichment of primary fibroblasts that strongly express SSEA3 resulted in a significantly greater efficiency (8-fold increase) of iPSC line derivation compared to the control derivation rate (p < 0.05, Table 1).