The vaccine, which was developed by the Vaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), is a 6 - plasmid mixture encoding HIV envelope subtypes A, B, and C and subtype B gag, pol, and nef, and an rAd5
expressing identical genes, with the exception of nef.
Not exact matches
Bacteria
expressing enzyme in one cell (bright green), while genetically
identical cells do not, remaining protected from antibiotic onslaught; image courtesy of Yuichi Wakamoto / Neeraj Dhar / John McKinney Some strains of nasty bacterial infections, such as MRSA (methicillin - resistant Staphylococcus aureus), come loaded with resistance to antibiotics built right into their
genes.
A famous example of how transcription factor expression can be used to alter a cell's identity is the creation of iPSCs, where adult cells were forced to
express transcription factors normally
expressed in ESCs, which made the adult cells
express genes specific to ESCs, and consequently become nearly
identical to ESCs.
This adds to the growing body of evidence showing how genetically
identical individuals can be different in the way their
genes are
expressed.
Before they reach maturity, however, macrophages and neutrophils — and the
genes they
express — are
identical.
Beyond the genetic information contained in DNA, the researchers examined patterns of DNA methylation — a molecular modification to DNA that affects when and how strongly a
gene is
expressed — across the genome in pairs of
identical male twins.