Not exact matches
«But if you have
stem cells that are over
expressing this protein TRAF6, they may proliferate longer and they may repair the
muscle much more effectively.»
In normal mice,
stem cells (pink)
express dystrophin (green) and are able to easily generate new
muscle fibers, but in the disease model, there is no dystrophin and the
stem cells lose their sense of direction and have trouble generating new
muscle fibers.
In the current study, Dr. Rudnicki and his team discovered that
muscle stem cells also
express the dystrophin protein, and without this protein, they produce ten-fold fewer
muscle precursor
cells, which in - turn generate fewer functional
muscle fibres.
Perivascular
cells, including pericytes in the smallest blood vessels (e.g., microvessels) and ARCs around larger ones,
express mesenchymal
stem cell markers and bear a multi-differentiation fate potential (differentiate into osteoblasts, chondrocytes, adipocytes, smooth
muscle cells and myocytes) similar to that documented for MSCs in vitro.
Using inducible
cell lineage tracing, we have found that early Pax7 -
expressing somitic
cells directly give rise to adult
muscle stem cells, i.e. the satellite
cells.