Sentences with phrase «expressing stem cell markers»

This assay detects cells that are able to give rise to new colonies containing a majority of cells that express stem cell markers.

Not exact matches

Previous research shows human induced pluripotent stem cells (hiPSCs)-- generated directly from adult cells — can express markers for a wide variety of cells, including those that secrete NP.

Whitehead Institute researchers have determined that the transcription factor Nanog, which plays a critical role in the self - renewal of embryonic stem cells, is expressed in a manner similar to other pluripotency markers.

Mouse embryonic stem cells injected into rat brains express the AHD2 protein marker (yellow) characteristic of cells lost in Parkinson's disease.

Significantly, cells with reduced mtDNA became self - renewing and expressed specific cell surface markers characteristic of breast cancer stem cells.

When transplanted to the subretinal space of mice lacking functional photoreceptors, human embryonic stem cells directed toward a retinal lineage integrate into the outer nuclear layer, express photoreceptor markers, and restore a light response as determined by the electroretinogram (ERG)[5].

Perivascular cells, including pericytes in the smallest blood vessels (e.g., microvessels) and ARCs around larger ones, express mesenchymal stem cell markers and bear a multi-differentiation fate potential (differentiate into osteoblasts, chondrocytes, adipocytes, smooth muscle cells and myocytes) similar to that documented for MSCs in vitro.

This gave a mixed population of cells with 20 % expressing CD34, a hematopoietic stem cell marker, with some co-expression of endothelial cell markers (CD31, Flk1, and VE - cadherin).

Solid tumours are reported to possess a sub set of cells called Side Population expressing various stem like cell markers, self - renewal capacity and ability to give rise to differentiated cells [23, 24].

Hematopoietic stem cells express the markers CD34 and CD133 and can repopulate a myeloablated recipient after allogeneic or autologous transplantation.

The scientists had strategically inserted these foreign DNA «markers» at particular points along the genome, next to genes expressed only in embryonic stem cells.

With this reporter we split ES cell cultures into two fractions that both express certain stem cell markers but only one of which expresses low levels of an endodermal marker gene.

(B) Percent of sorted single HES3 cells in (A) expressing stem or lineage markers according to level of surface marker expression.

The GFP+HPC s expressed a whole range of leukocyte and stem cell markers including CD45, CD11b, CD31; relatively low levels of MHC class I; and no class II antigens, as we recently reported [17].

We derived a fibroblast line from a skin biopsy from a healthy adult male (HUF1)(Figure 1A) and used immunocytochemistry to characterize the expression of cell surface markers commonly expressed on pluripotent stem cells (Figure 1B, C and D).

We have also shown that ΔNp63, a stem cell marker, is not expressed in the human corneal endothelium.

These iPS cells have a normal karyotype, demonstrate telomerase activity and express embryonic stem (ES) cell surface markers.

Holoclones express high levels of stem and progenitor cell markers CD44, α2β1 integrin, and β - catenin.

Oct - 4 is most consistently expressed of the pluripotency genes that we have studied, and it is switched off only in populations that have lost other measurable features of pluripotency, such as stem cell surface marker expression and the capacity for self - renewal.

(B) Percent of isolated single cells expressing stem or lineage markers according to location with the colony.

The fact that all three markers are expressed in essentially all cells in the holoclones suggests that these three molecules are probably expressed in both cancer stem and progenitor cells.

In support, PC3 cell holoclones, but not meroclones and paraclones, express three well - established stem and progenitor cell markers.