Sentences with phrase «expression by neurons»

Not exact matches

Scientists at Southern Methodist University, led by Professor and Chair of Biological Sciences Santosh D'Mello, have used RNA - Seq to conduct transcriptome profiling of gene expression changes in dying neurons.

In GluR - A — deficient mice, plasticity could be restored by controlled expression of green fluorescent protein (GFP)-- tagged GluR - A, which contributes to channel formation and displayed the developmental redistribution of AMPA receptors in CA1 pyramidal neurons.

Investigators at Duke University, led by Erica Davis, PhD, a co-senior author of the report, blocked the gene's expression in zebrafish, which resulted in abnormal facial cartilage, smaller eyes and structural abnormalities of neurons involved in the development of reproductive organs.

They began by characterizing the cell composition, protein expression, metabolism, and electrical activity of neurons from each region in vitro.

They also applied it to human brain tissue collected by the Genotype - Tissue Expression (GTEx) Project, finding that they could a) identify expression signatures unique to neurons, glial cells, and other cell types in the brain (including rare types), and b) differentiate between closely related cellExpression (GTEx) Project, finding that they could a) identify expression signatures unique to neurons, glial cells, and other cell types in the brain (including rare types), and b) differentiate between closely related cellexpression signatures unique to neurons, glial cells, and other cell types in the brain (including rare types), and b) differentiate between closely related cell subtypes.

By comparing gene expression in the brains of resilient and avoidant mice, Berton and colleagues discovered that bullying in avoidant mice puts GABA neurons in a state where they become more excitable and the mice exhibit signs of social defeat.

Blue corresponds to cell nuclei, and green to fluorescence emitted by a green - fluorescent protein that identifies neurons having received the virus that can genetically abolish the expression of lipoprotein lipase protein.

The researchers discovered that the Activin pathway controls the ability of cocaine to induce this change in the neurons and determined that the Activin receptor may control this response to cocaine by regulating the expression of a number of genes.

The researchers report in Neuron that serotonergic neurons come in at least six major molecular subtypes defined by distinct expression patterns of hundreds of genes.

«The thing that's impressive is that morphological changes in the neurons that many labs have seen, both in fragile X patients as well as in mice that model fragile X, were reversed by changing the expression of this PAK gene.

The researchers showed these relationships between ecRNA production and gene activity in neurons included genes whose expression is altered by neuronal activity and genes implicated in developmental and neurodegenerative disorders.

In this study, published in Nature 2010, Vierbuchen and colleagues showed that fibroblasts can be converted into neurons by false expression of defined transcription factors.

The project will focus on the mechanisms by which the three tau - mRNA binding proteins HuD, IMP - 1 and G3BP - 1 affect tau localization and expression in neurons.

To test this possibility, it will be necessary to examine whether the Acks - expressing neurons are A3v neurons by double staining for Acks expression and immunoreactivity to GAD, a GABA - synthesizing enzyme.

Guidepost neurons for the lateral olfactory tract: Expression of metabotropic glutamate receptor 1 and innervation by glutamatergic olfactory bulb axons.

Despite this ubiquitous SMN expression, the pathology is characterized by degeneration of spinal Motor neurons whereas other neuronal types are relatively preserved suggesting that spinal motor neurons specific features control this differential sensitivity.

Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells

A team led by Dr. Alexey Terskikh at Sanford - Burnham Medical Research Institute (Sanford - Burnham) recently found that expression of a gene called SOX2 maintains the potential for neural crest stem cells to become neurons in the peripheral nervous system, where they interface with muscles and other organs.

By studying the expression of these genes, the neurons that mediate learning have been identified.

We first sought to gain insight into the biological processes that may be altered by elevated miR - 181a expression in the mDA neurons in PD [13].

Survival motor neuron protein deficiency impairs myotube formation by altering myogenic gene expression and focal adhesion dynamics.

By combining neuronal tracing with behavioral experiments leading to sensory - driven gene expression of the neuronal activity marker ZENK during magnetic compass orientation, we demonstrate a functional neuronal connection between the retinal neurons and Cluster N via the visual thalamus.

By increasing expression of Ran, the researchers were able to elevate TDP - 43 levels in the nucleus of progranulin - deficient neurons and prevent their death.

Because over - or mis - expression of UNC - 7S driven by Punc - 7S in interneurons rescues forward locomotion in e5 animals, it appears that any intra-class motor neuron junctions to which UNC - 7 contributes may not be crucial for locomotion, or UNC - 9 homotypic channels might compensate for the loss of UNC - 7 in motor neurons.

A translational fusion of Punc - 7S in the GFP expression vector pPD95.67 (provided by A Fire) was injected at a concentration of 50 ng / μl and found to express in various head neurons but not in ventral nerve cord motor neurons.

Moreover, because trans - Tango works by instigating the expression of genes in connected pairs of neurons, it also has the potential to enable scientists to control circuit functions, says senior and corresponding author Gilad Barnea, PhD, an associate professor of neuroscience who began looking for a precise, reliable, and general way to visualize neural connections two decades ago.

It also suggests that in unc - 9 mutants, the native UNC - 7 isoforms expressed in motor neurons (as detected by previous analysis of total UNC - 7 expression) are insufficient to properly localize AVB - expressed UNC - 7S:: GFP (that is, UNC - 7 in motor neurons does not substitute for UNC - 9 in localizing AVB - expressed UNC - 7S).

Now, two independent groups report having made the process even simpler, by soaking fibroblasts in combinations of small molecules, thereby obviating the need to tinker with gene expression to turn the cells into neurons.

By affecting the rate of cell differentiation and gene expression, thyroid hormones regulate the growth and migration of neurons, including synaptic development and myelin formation in specific brain regions.