Sentences with phrase «expression level for»

More importantly, though, they found about a two-fold higher PD - L1 expression level for gastroesophageal cancers compared to right - side colon cancers but did not find such a marked difference between those tumors and SBAs.

We used CIBERSORT35, to deconvolute bulk gene expression into expression levels for 18 different cell types.

A web - based tool in which users can upload their individual SNP data and obtain predicted expression levels for the set of predictable genes across the 14 different cell types.

For each slice digital RNA sequencing was performed providing expression levels for the entire transcriptome, annotated with the head - to - tail coordinates of the slice: a protocol they call «tomo - seq».

Not exact matches

The PRPA has already completed substantial pre-development work at the sites, improving access, in anticipation of private development spurred by a Request for Expressions of Interest (REI) that was issued late last year and, the port authority said, «garnered a high level of response from maritime industry, manufacturing, and energy companies.»

That site has some really excellent posters you might want to take a look at as well (oh, and it might help get the extra layer of meaning if you know that «po - mo» is also slang for «post modern» which is a term used to describe the meta - level / self - satirize / surreal sort of cultural expression that followed the «modernist» movements): http://www.spurgeon.org/~phil/posters.htm

This means that a Prolog program interpreted at its most abstract level as a logical or mathematical structure is a symbolic expression for an eternal object.

That goal is the expression, on the level of duty, of the demand, the claim — the Verlangen — which constitutes pure reason in its speculative and practical use; reason «demands the absolute totality of conditions for a given conditioned thing» (beginning of the Dialectic of the Critique of Practical Reason).

The very expression «postulate» should not mislead us; it expresses, on the properly epistemological level and in the language of modality, the «hypothetical» character of the existential belief involved in the demand for completion, for totality, which constitutes practical reason in its essential purity.

On one level Christians who adopt this position develop program material that — in contrast to the media's expressions — tries to illumine the human condition, to ask meaningful religious questions, to rediscover religious truths, and even to create a new religious vocabulary that has meaning and power for the multitudes.

But it is precisely because this feeling remains for the most part buried beneath the level of our immediate awareness that we need symbolic expression to bring this value into our conscious awareness so as to bolster and vivify our capacity to trust.

Perusing the index of Origins, the weekly publication of representative documents and speeches compiled by Catholic News Service, our imaginary historian will note, for example, the following initiatives undertaken at the national, diocesan and parish levels in 1994 - 95: providing alternatives to abortion; staffing adoption agencies; conducting adult education courses; addressing African American Catholics» pastoral needs; funding programs to prevent alcohol abuse; implementing a new policy on altar servers and guidelines for the Anointing of the Sick; lobbying for arms control; eliminating asbestos in public housing; supporting the activities of the Association of Catholic Colleges and Universities (227 strong); challenging atheism in American society; establishing base communities (also known as small faith communities); providing aid to war victims in Bosnia; conducting Catholic research in bioethics; publicizing the new Catechism of the Catholic Church; battling child abuse; strengthening the relationship between church and labor unions; and deepening the structures and expressions of collegiality in the local and diocesan church.

«It was great to taste such a range and in our group we found that wines in the medium to premium range that wines are consistently showing technical precision and also a level of expression,» stated Yvonne Cheung, director of wine for Swire Hotels and Restaurants.

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Four suction levels allow for efficient expression, controlled by mom to suit her needs and comfort.

Control: The two dials on the Simplisse pump allow for customized levels of milk expression.

In animal models, exposure to cigarette smoke or nicotine during fetal development alters the expression of the nicotinic acetylcholine receptor in areas of the brainstem important for autonomic function, 28 alters the neuronal excitability of neurons in the nucleus tractus solitarius (a brainstem region important for sensory integration), 29 and alters fetal autonomic activity and medullary neurotransmitter receptors.30 In human infants, there are strong associations between nicotinic acetylcholine receptor and serotonin receptors in the brainstem during development.31 Prenatal exposure to tobacco smoke attenuates recovery from hypoxia in preterm infants, 32 decreases heart rate variability in preterm33 and term34 infants, and abolishes the normal relationship between heart rate and gestational age at birth.33 Moreover, infants of smoking mothers exhibit impaired arousal patterns to trigeminal stimulation in proportion to urinary cotinine levels.35 It is important to note also that prenatal exposure to tobacco smoke alters the normal programming of cardiovascular reflexes such that there is a greater - than - expected increase in blood pressure and heart rate in response to breathing 4 % carbon dioxide or a 60 ° head - up tilt.36 These changes in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SIDS.

During his time at the Pride Agenda he has been actively involved with the passage of dozens of laws, ordinances, regulations and Executive Orders on the state and local level affecting New York's LGBT community, including statewide measures like: the Sexual Orientation Non-Discrimination Act; the Hate Crimes Act of 2000; making the state's 9/11 relief inclusive of same - sex couples; guaranteeing domestic partners hospital visitation, legal authority over a loved one's bodily remains, access to Family Court and medical decision making authority; prohibiting discrimination on the basis of gender identity and expression in state employment; and securing over $ 50 million of funding for LGBT health and human services.

A new meta - analysis suggests that low expression levels of 10 related gene sets responsible for mitochondrial machinery play an important role in this disorder — all previously unlinked to Parkinson's.

Hypoxia - inducible factor 1α (HIF - 1α), an oxygen sensor that controls the expression of various genes for glucose metabolism under conditions of low oxygen levels, is the most well documented substrate of the von Hippel - Lindau (VHL) enzyme.

It adds extra levels of engagement and emotional intensity to television, games, music and art, as well as offering novel pathways for artistic expression.

Those studied by Dunlop are her colleagues alter their traits — protein expression, for instance — but not their genomes, making them significantly more difficult to identify since the resistance level of each bacterium changes over time.

«The genes which these miRNAs regulate also had increased levels, indicating that these gene expression, indicating that these gene products were likely targeted for storage and for possible future use within the brain cell, rather than for destruction.

In addition, researchers will scan the tumors for their RB gene expression to test whether low levels of RB correlate with strong responses to cabazitaxel.

«For the first time, our study identified detailed gene expression levels in these granules.

To validate their findings, the scientists injected the novel nanoparticles into pancreatic tumor - bearing mice and observed that by balancing these two targets — bringing them to a normal level by increasing their expression or blocking the gene responsible for their expression — they significantly prolonged the survival of the mice.

The researchers named the method after a fish famous for swimming upstream because it employs an algorithm that can estimate the effect of biases and the expression level of genes as experimental data streams by.

When a single gene exists in the ancestral mutation, that would have made for higher levels of enzyme expression, would have messed up with sensory function.

Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (effector memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T cells in the central memory (TCM) and effector memory (TEM) subsets.

Bellen adds that among other things, the method eliminates the need to reintroduce the same transgene over and over again and look for an average effect: «Now you need only one transgene, because if you inject into the same site, you'll always have the same expression level and the same position effect.

Association of a protein biomarker with any given disease process, for example, needs to be assessed in terms of disease - independent, confounding factors that may modulate protein expression levels among different individuals.

«Interestingly, because deltaFosB is a transcription factor, meaning that its job is to regulate the expression of other proteins, these findings led us to predict that the increased deltaFosB levels might be responsible for suppressing the production of proteins that are necessary for learning and memory,» Chin said.

Thomas and his colleagues began this study by searching for other possible IFITM3 variants that correlated with gene expression, levels of the IFITM3 proteins and were common in flu patients in the U.S..

Engelhardt's group was responsible for mapping associations between genetic variants and gene expression levels on different chromosomes, a connection known as «trans - expression quantitative trait loci (trans - eQTLS).»

«DNA methylation is a key mechanism by which day length and melatonin levels exert seasonal control over the expression of the deiodinase enzyme known as dio3, and dio3 expression likely acts as a key step for the maintenance of reproductive competency during the breeding season,» said co-author Tyler Stevenson, senior lecturer at the Institute of Biological and Environmental Sciences at the University of Aberdeen in Scotland.

Unlike some types of RNA, microRNAs (miRNAs) do not code for proteins but instead regulate various biological processes by modulating the level of gene expression.

However, the team was able to show that so - called tight junction proteins, which are known to be important for the blood - brain barrier permeability, did undergo structural changes and had altered levels of expression in the absence of bacteria.

Identification of a specific learning disability is based on determination of the following Individual with Disabilities Education Improvement Act (IDEA): The child does not achieve commensurate with his / her age and ability levels in one or more of the seven areas (oral expression, listening comprehension, written expression, basic reading skill, reading comprehension, mathematical calculations or mathematical reasoning) when provided with learning experiences appropriate for the child's age and ability levels.

Natural variation exists in the levels of pectate lyase gene expression in wild relatives of cultivated tomato and these can be used for conventional breeding purposes.

Unlike most biomarkers for cancer, DDX3 mRNA expression only increased slightly in the exposed breast cells, but the corresponding proteins levels were significantly higher.

«These findings suggest that focusing on genes with conserved expression levels among primates may be helpful in identifying promising candidates for disease - association studies,» the researchers write.

Encouraged by the study results, the team suggests that it may now be technologically possible to screen for cancer by checking expression levels of bronchial airway cell genes.

Although the developmental stages they analyzed in the human embryos — gestation weeks 8 to 9 and 17 to 18 — occur before the folds begin to appear, Borrell says, the varying levels of gene expression provide an «instruction for something to occur.»

Previous studies have shown a physiologic role for vitamin D in liver function, but «it was our discovery of high levels of vitamin D receptor (VDR) in the stellate cell that led us to consider it as a possible off switch for liver fibrosis,» says lead author Ning Ding, a research associate in the Gene Expression Laboratory.

When the team analyzed tissues from 261 patients with NSCLC, they found an inverse correlation between the two molecules; that is, more than 80 percent of patient tissues with low levels of the tumor suppressing C / EBPα were positive for BMI1 expression.

The expression of mRNA for factors involved in promoting mitochondrial biogenesis, including the transcription factor Ppard, the PPARδ coactivator Pgc - 1α, and citrate synthase was greater in gastrocnemius muscles from IL - 15Rα — KO relative to B6129 control (Figure 5C); however, levels of these genes were unchanged in spleen and kidney (data not shown).

Quantitative real - time PCR showing levels of expression of several selected membrane transporters in testes from mice treated with drug at 1.0 mg for 4, 8, or 16 weeks.

The affinity of B cell receptor for antigen and the expression level of Bach2 are inversely correlated in germinal center B cells.

Samples from each cDNA pool were diluted 1:10, 1:30, 1:90, and 1:270 in order to create a standard curve for calculation of relative gene expression levels.

The importance of CCR5 for HIV - 1 pathogenesis is shown by the fact that individuals who are homozygous for an inactivating 32 base pair deletion in ccr5 (ccr5Δ32) are highly resistant to HIV infection [2], [3], while heterozygotes typically live longer after HIV infection due to reduced CCR5 expression levels [4], [5].