Sentences with phrase «expression of adhesion»
Resveratrol has been found to inhibit the expression of adhesion molecules in cultured endothelial cells (43, 44).
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Plakoglobin is a component of two important structures involved in cell - to - cell adhesion, and the investigators found that suppressing its expression caused CTC clusters to fall apart, reducing their metastatic potential, and also disrupted cell - to - cell contact between breast cancer cells but not normal breast tissue.
Anyone who seriously proposes that there is a force beyond gene expression, signaling molecules, differential adhesion, and those kinds of mechanisms, just doesn't know what they are talking about.
Dr. Islam's discovery was published [S. Islam, T. E. Carey, G. T. Wolf, M. J. Wheelock, and K. J. Johnson, «Expression of N - Cadherin by human squamous carcinoma cells induces a scattered fibroblastic phenotype with disrupted cell - cell adhesion,» J. Cell Biol.
The lab previously found that Bam is required to repress the expression of E-cadherin, a cell - to - cell adhesion molecule that tethers adult stem cells to their tissue niches and promotes GSC self - renewal.
The constitutive and inducible expression of the endothelial cell adhesion molecules E-selectin, ICAM - 1, and VCAM - 1 was assessed by immunohistochemistry (Figs. 4, A — C) ⇓.
The constitutive expression of these endothelial cell adhesion molecules was very similar for most of the lines derived from different organs, i.e., very low expression levels of E-selectin and VCAM - 1 and more pronounced expression of ICAM - 1.
Established cell lines exhibited several inherent endothelial properties, including the expression of constitutive and inducible levels of endothelial cell adhesion molecules E-selectin, intercellular adhesion molecule - 1, and vascular cell adhesion molecule - 1, internalization of acetylated low - density lipoprotein, and formation of loop structures on Matrigel surfaces.
To determine inducible endothelial cell adhesion molecule expression (E-selectin, VCAM - 1, and ICAM - 1), some of the chambers were given medium containing 10 ng / ml TNF - α for 4 — 6 h (these time points were selected to correlate with the known kinetics of endothelial cell adhesion molecule expression; Refs.
However, because IFN - γ is widely known to influence several endothelial properties, such as junctional integrity (21) and adhesion molecule expression (22), we elected to remove this cytokine from cultures immediately after the second session of cell selection.
Up - regulated expression of zonula occludens protein - 1 in human melanoma associates with N - cadherin and contributes to invasion and adhesion.
Alteration of collagen - dependent adhesion, motility, and morphogenesis by the expression of antisense a2 integrin mRNA in mammary cells.
Current projects are investigating: 1) the expression of inflammatory genes during ischemia and reperfusion of kidneys during urology transplantation and in mouse models; 2) the expression of inflammatory genes and proteins in urine as markers indicating the presence of rejection in renal allografts; and 3) the role of adhesion molecules and chemokines in directing leukocyte infiltration into organ allografts.
In vivo imaging of endothelial cell adhesion molecule expression after radiosurgery in an animal model of arteriovenous malformation.
A study has shown that the immunosuppressive effect of MSCs is mediated by the secretion of galectin - 3, a protein known to modulate T cell proliferation, gene expression, cell adhesion and migration 44.
Expression of the melanoma cell adhesion molecule in human mesenchymal stromal cells regulates proliferation, differentiation, and maintenance of hematopoietic stem and progenitor cells.
BCR / ABL expression of myeloid progenitors increases beta1 - integrin mediated adhesion to stromal cells.
Functional expression of CXCR4 (CD184) on small - cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells.
The work has led him to explore the role of protein phosphorylation in a diverse array of cellular functions, including transformation, cell communication, cell adhesion, cell - cycle regulation, the control of gene expression, and protein degradation.
Expression of the receptor tyrosine kinase Tie2 in neoplastic glial cells is associated with integrin beta1 - dependent adhesion to the extracellular matrix.
Intercellular adhesion molecule - 1 expression is required on multiple cell types for the development of experimental autoimmune encephalomyelitis.
Increased expression of Cd11b - a marker of macrophages [38] seen with L - arginine admininistration in WNIN / Gr - Ob rats, might be due to increased influx of inflammatory cells in the exocrine fraction via adhesion molecules [17].
Approximately 50 % of PTCL are unclassifiable and categorized as PTCL, not otherwise specified (PTCL - NOS).1 Using gene expression profiling, PTCL - NOS lymphocytes can be distinguished from normal T lymphocytes, with deregulation of genes involved in apoptosis, proliferation, cell adhesion, and transcription regulation.2 Two subgroups of PTCL - NOS have been identified, which are characterized by high expression of either GATA3 or TBX21 / T - bet transcription factors and downstream target genes.3 However, actionable biomarkers closely related to the pathogenic mechanism need to be further investigated and may become potential therapeutic targets of PTCL - NOS. 4, 5
Based on the glycosylation targets of GalNAc - T6 in the cancer cell lines, the authors hypothesized that expression of the enzyme disrupts epithelial development in the colon by affecting cell - cell adhesion.
Their antioxidant and anti-inflammatory activities are largely due to their abilities to scavenge the reactive oxygen species (ROS) and improvement of antioxidant status by attenuating the activity of NF - κB and suppressing the expression of several inflammatory cytokines and chemokines including monocyte chemotactic protein - 1 (MCP - 1), nitric oxide synthase, cyclooxygenases, lipoxygenases, cellular adhesion molecules, tumor necrosis factor and interleukins.
Besides promoting immunogenicity of the thyroglobulin molecule, dietary iodine can enhance levels of reactive oxygen species (ROS), which lead to expression of cell adhesion molecules (ICAM - 1) that are crucial to the early phases of thyroid follicular inflammatory responses (3).
A recent in vitro study showed that incorporating a greater extent (2-fold) of TFA in the phospholipid fraction of endothelial cells significantly increased the expression of endothelial adhesion molecules, including ICAM - 1 (25).
Flavonoids, including anthocyanins, seem to modulate this type of monocyte adhesion during the inflammatory process by decreasing their expression by endothelial cells.