Sentences with phrase «expression of adipocyte»
Bone marrow mesenchymal stem cells and bone cells from the skulls of Cbf - beta - deficient mice showed increased expression of adipocyte genes.
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The Cbf - beta / Runx2 complex also inhibited expression of the enhancer protein C / EBP - alpha that promotes differentiation of adipocytes.
It is considered that methods to convert white adipose tissues * 7 into the ones containing beige adipocytes with increased expression of UCP - 1 would lead to prevention and treatment of obesity.
The accumulation of adipose tissue macrophages in direct proportion to adipocyte size and body mass may explain the coordinated increase in expression of genes encoding macrophage markers observed in our microarray expression data.
The expression rates of three macrophage - specific genes (Emr1, Cd68, and Csf1) that correlated with body mass in our microarray studies, an adipocyte - specific gene (Acrp30), and proinflammatory genes (Tnfa, Nos2, Il6) were determined by quantitative RT - PCR.
Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild - type mice
Quantitative RT - PCR was used to measure the relative expression of macrophage markers (Emr1, Csf1r, Cd68) and an adipocyte - specific gene (Acrp30).
We found that both BMI (r2 = 0.43, P < 0.01; Figure 9) and average adipocyte cross-sectional area (r2 = 0.46, P < 0.05; data not shown) were significant predictors of Cd68 expression.
These data demonstrate that variations in continuous quantitative traits such as body mass, adipocyte size, and BMI are correlated with quantitative variations in the expression of genes.
Simultaneously, Lsd1 promotes the expression of genes containing information for brown adipocytes.
The enzyme inhibits the expression of the genes which contain the information for white adipocytes.
Ferron M, Hinoi E, Karsenty G, Ducy P. Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild - type mice.
These findings suggest that specific MFN2 mutations cause tissue - selective mitochondrial dysfunction with increased adipocyte proliferation and survival, confirm a novel form of excess adiposity with paradoxical suppression of leptin expression, and suggest potential targeted therapies.
Compared to PHWSC adipocytes, SGBS adipocytes showed not only greater induction of adipogenic gene expression during differentiation but also increased levels of UCP1 mRNA and protein expression.
It is accepted that the regulation of adipocytokine secretion or the adipocyte specific gene expression is one of the most important targets for the prevention of obesity and amelioration of insulin sensitivity.
Recently, we demonstrated that anthocyanins, which are pigments widespread in the plant kingdom, have the potency of anti-obesity in mice and the enhancement adipocytokine secretion and adipocyte gene expression in adipocytes.
Treated adipocytes with anthocyanins enhanced adipocytokine (adiponectin and leptin) secretion and up - regulated the adipocyte specific gene expression without activation of PPARgamma in isolated rat adipocytes.
Based on the gene expression profile, we demonstrated the up - regulation of hormone sensitive lipase and enhancement of the lipolytic activity by the treatment of adipocytes with C3G or Cy.
It is accepted that the regulation of adipocytokine secretion or the adipocyte - specific gene expression is one of the most important targets for the prevention of obesity and amelioration of insulin sensitivity.
Butyrate, a short - chain fatty acid produced from the microbial fermentation of dietary fiber, has been shown to increase leptin expression in adipocytes (8) and improve insulin sensitivity (9, 10).
Other studies at the molecular level have shown Berberine changes the expression of PPARgamma2 mRNA genes to inhibit formation of adipocytes (fat cells)(19, 20).
-- «Resistin and Type 2 Diabetes: Regulation of Resistin Expression by Insulin and Rosiglitazone and the Effects of Recombinant Resistin on Lipid and Glucose Metabolism in Human Differentiated Adipocytes»; Philip G. McTernan et al; The Journal of Clinical Endocrinology & Metabolism; 2003
Ryan VH, German AJ, Wood IS, Hunter L, Morris P, Trayhurn P. Adipokine expression and secretion by canine adipocytes: stimulation of inflammatory adipokine production by LPS and TNFalpha.