Sentences with phrase «expression of growth factors»

Several research groups are pursuing gene therapy approaches to regenerate skin, such as using genes to control expression of growth factors involved in skin healing.

Not exact matches

The survey bears out that the caliber of leadership is a far more determinative factor in church growth than questions of liberal - versus - conservative positions, or social action versus personal - individual religious experience and expression.

The cannabinoids inhibited the expression of several genes critical to angiogenesis known as the VEGF (vascular endothelial growth factor) pathway.

Vibration helped tissue to form new blood vessels — a process called angiogenesis — and also led to increased expression of pro-healing growth factors and signaling molecules called chemokines, Weinheimer - Haus said.

This chimera, created by a team at the Georgia Cancer Center, has the ability to simultaneously decrease the expression of three growth factors that are over-expressed in some cancers.

They found higher levels of JAK1 in resistant tumors, which caused increased expression of epidermal growth factor receptor (EGFR)-- a receptor tyrosine kinase that promotes cell proliferation.

For the current study, the Stowers researchers focused on a differentially imprinted control region, which drives the reciprocal expression of H19 from the maternal allele and Igf2 (Insulin growth factor 2) from the paternal allele.

The researchers show that higher expression of the growth hormone IFG2, or insulin - like growth factor 2, is indicative of iPS cells initiating their conversion into hematopoietic cells.

In these images of rat brains, differences in gene expression of genes for fibroblast growth factor 2 (FGF2, top set) and dopamine 2 receptor (D2, bottom sett) can be seen in rats of two breeds before (left) and after (right) cocaine exposure.

In addition to publishing the discovery of the «speed gene» — actually a gene that controls the expression of the muscle growth factor, myostatin, in a January 2010 Public Library of Science paper — she has published research on several more genes and is seeking patents for some, including myostatin (MSTN).

The team suspects the difference may be due to the expression of a gene that codes for a growth factor called bone morphogenetic protein 2 (Bmp2); expression was 30 % higher in the developing forelimbs of bats than it was in mice.

Expanding from their previous studies with mice, the researchers first established that under specific conditions, culturing human embryonic stem cells with fibroblast growth factor 2 (FGF2) leads to neural differentiation particular to the midbrain / hindbrain region — the location of the cerebellum — within three weeks, and the expression of markers for the cerebellar plate neuroepithelium — the part of the developing nervous system specific for the cerebellum — within five.

Mycoplasma compete with host cells for nutrients and can alter expression of receptors, ion channels, and growth factors resulting in changes to the cell line's growth and behavior.

Human cytomegalovirus downregulates expression of receptors for platelet - derived growth factor by smooth muscle cells.

Inverse relationship between epidermal growth factor receptor expression and radiocurability of murine carcinomas.

Increased transforming growth factor beta expression inhibits cell proliferation in vitro, yet increases tumorigenicity and tumor growth of Meth A sarcoma cells.

Loss of Vascular Endothelial Growth Factor A (VEGFA) Isoforms in the Testes of Male Mice Causes Subfertility, Reduces Sperm Numbers, and Alters Expression of Genes That Regulate Undifferentiated Spermatogonia.

PromoKine offers a wide range of well proven products for cell biology research such as kits and reagents for cell analysis, apoptosis research, cell transfection, fluorescent labeling, gene cloning & expression, mycoplasma detection and elimination as well as numerous antibodies, ELISAs, cytokines and growth factors.

«What we're seeing may not only be happening in limbs, but the action of these two families of growth factors could be very important for the genesis of a wide range of organs in the body,» said Juan Carlos Izpisúa Belmonte, a professor in the Gene Expression Laboratory at Salk and the principal author of the Cell paper.

Each subtype was classified by gene expression clustering, and showed specific patterns of genetic alterations, particularly for four genes: platelet - derived growth factor receptor alpha (PDGFRA), isocitrate dehydrogenase 1 (IDH1), epidermal growfth factor receptor (EGFR), and neurofibromin 1 (NF1).

Six ovarian factors (BDNF, IGF - I, estradiol, GDNF, leptin and FGF2) were further studied based upon the expression of their receptors in oocytes and cumulus cells described above, as well as the availability of growth factor concentration information from previous animal model studies [1], [20], [21], [22], [23].

Through its various targets, MMP1 promotes not only tumor invasion but also breast cancer colonization to bone by mechanisms that include the release of membrane - bound EGF - like growth factors from tumor cells, leading to activation of EGF receptor signaling and suppression of OPG expression in osteoblasts, which in turn promotes the differentiation and activation of osteoclasts required for bone destruction and enhanced tumor growth in the bone microenvironment (32).

Among the growth factors, expression of mRNA of genes that encode for GDNF, FGF2, GM - CSF and TGF - β1 was significantly higher in cumulus cells than in oocytes.

Assessment of hASC - CM composition found high expression of various human growth factors (IL ‐ 6, 8, 12, eotaxin, IP10, MCP ‐ 1, VEGF, and TIMP ‐ 1) in the supernatant following the co-culture of hASCs with islet cells, while IP10, eotaxin, VEGF, and TIMP ‐ 1 became increased with time during islet co ‐ culture, suggesting the presence of paracrine cross ‐ talk between islets and hASCs.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Chemotherapy is a key part of the standard treatment regimen for triple - negative breast cancer patients whose cancer lacks expression of estrogen and progesterone receptors and the human epidermal growth factor receptor 2...

In order to improve culture conditions for maturation of cumulus - free oocytes in vitro, we began by assaying the expression of 15 growth factors (BDNF, IGF - I, estradiol, GDNF, leptin, FGF1, FGF2, GM - CSF, EGF, TGF - α, TGF - β1; 2; 3, and ET - 1; 2) and 27 of their cognate receptors that have been shown to regulate oocyte maturation.

Inhibition of growth, production of insulin - like growth factor - II (IGFII), and expression of IGF - II mRNA of human cancer cell lines by antagonistic analogs of growth hormone - releasing hormone in vitro.

No expression of SCP3 was detected in the any of the conditioned EBs examined, whereas the expression of SCP1 was detected from day 21 EBs cultured with BMP4, and detected in day 28 EBs cultured in the absence of growth factors and with RA.

The current findings could provide important clues to determine the culture conditions for promoting the differentiation of primate ES cells into mature gametes, and to understand molecular mechanisms of primate gametogenesis including the timing of germ cell induction, the regulation of germ cell gene expression, and the response to growth factors for germ cell differentiation.

Results: Fibroblast growth factor 2 (FGF2) treatment reduced expression of β - cell markers, (INS, MAFB, SLC2A2, SLC30A8, and GCK) and activated ectopic expression of MYC, HES1, SOX9, and NEUROG3.

The pathways that connect expression of stem cell surface glycoconjugates such as the TRA -1-60 / GCTM - 2 antigen, receptors, and growth factors in human and even mouse ES cells with the transcriptional networks that regulate pluripotency remain unclear.

Expression of mTert in primary murine cells links the growth - promoting effects of telomerase to transforming growth factor - beta signaling.

One theory proposes that once the storage capacity of subcutaneous adipose tissue (SAT) depots is exceeded under conditions of energy excess, either as a result of impaired expandability and / or excessive hypertrophic growth, fat deposition within visceral depots and non-adipose tissues including the liver, skeletal muscle and pancreas can ensue.93 This can subsequently lead to the development of systemic IR and a series of associated cardiometabolic disorders including dyslipidaemia, dysglycaemia, hyperinsulinaemia and hypertension.3 Expression of pro-inflammatory mediators including interleukins 1 (IL - 1), 6 (IL - 6), tumour necrosis factor alpha (TNF - α) and resistin, are also increased which can further potentiate IR and promote atherosclerosis.

104 Several hormetic response pathways have been identified involving enzymes (kinases and deacetylases including Sirtuins), transcription factor - regulation the expression of several major categories of proteins including chaperones, antioxidant enzymes and growth factors.

Hormesis: an alternative longevity mechanism There are some other lifestyle factors that can also boost the expression of stress resistant genes without the downsides to low levels of growth hormone and IGF - 1.

This makes your muscles look bigger, of course, but also positively influences several factors related to muscle growth, including nitrogen balance and the expression of certain genes.

In the fasted state these undesirable growth factors that act in a cascading domino fashion on reactant signalling pathways are metabolically inhibited or «dulled» for want of a better expression (at least I tried eh?

The gene expression is influenced by a variety of factors including gender, nutrition, breed, rate of growth, and amount of exercise.