Sentences with phrase «expression of particular genes»

Registry parts include operators, which are segments of DNA to which repressor proteins bind to prevent gene transcription; cell - cell signaling elements, which produce defined outputs in response to specific chemical inputs; and riboregulators, which can be used to suppress the expression of particular genes by preventing translation of proteins they express.

And we've been able to demonstrate that the altered expression of those particular genes actually mediate the symptoms seen.

These epigenetic switches and markers in turn help switch on or off the expression of particular genes.

Not exact matches

Your baby's abilities are just as unique as the way she looks yet somehow it is easier to accept the expression of eye - color genes than those that determine when your baby will hit a particular milestone.

Recent advances in the understanding of cancer have led to more personalized therapies, such as drugs that target particular proteins and tests that analyze gene expression patterns in tumors to predict a patient's response to therapy.

Of particular interest are the emerging techniques for genomics and proteomics, which allow profiles of gene expression and protein synthesis to be produced and comparisons to be made between normal and abnormal cells, as well as between cells before and after exposure to medicines or toxic chemicalOf particular interest are the emerging techniques for genomics and proteomics, which allow profiles of gene expression and protein synthesis to be produced and comparisons to be made between normal and abnormal cells, as well as between cells before and after exposure to medicines or toxic chemicalof gene expression and protein synthesis to be produced and comparisons to be made between normal and abnormal cells, as well as between cells before and after exposure to medicines or toxic chemicals.

What we found is that the ability of this chronic social stress to produce maladaptive changes in brain and behavior — loss of pleasure, inability to sleep normally and so on — are mediated through epigenetic modifications of gene expression, in particular, emotional centers of the brain.

Nestler: The ability of this chronic social stress to produce maladaptive changes in brain and behavior are mediated through epigenetic modifications of gene expression in particular emotional centers of the brain.

Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNA.

In particular, the protein enhances the expression of a well - characterized oncogene called MYC, which in turn regulates a large number of genes involved in cell proliferation.

The expression of specific genes in a particular root cell determine its fate — the zone in which it will function, Subramanian explained, so he is identifying which micro-RNAs direct gene expression to achieve this differentiation.

And next - generation sequencing, in particular, RNA sequencing, allows researchers to delineate changing patterns of gene expression as new cell types form.

In particular they observed for the first time a transient pulse of gene expression that precedes the segmentation of the human embryo into discrete parts that will become the head, trunk and limbs of the body.

«This data allows classification of all human protein - coding genes into those coding for house - hold functions (present in all cells) and those that are tissue - specific genes with highly specialized expression in particular organs and tissues, such as kidney, liver, brain, heart, pancreas.

«We were surprised to see that expression of the gene TSLP — which encodes a cytokine long known to be involved in epithelial - induced inflammation — was exclusive to a particular subset of tuft cells,» Haber noted.

By designing the short pieces of RNA to match one particular gene, the intracellular response will specifically silence the expression of that gene.

Of particular interest to us are microRNAs: 22 nucleotide RNAs that can regulate the expression of protein - coding geneOf particular interest to us are microRNAs: 22 nucleotide RNAs that can regulate the expression of protein - coding geneof protein - coding genes.

We design short interfering RNA (siRNA) molecules that are able to trigger the RNAi pathway and mediate the degradation of specific target messenger RNAs (mRNAs), resulting in the expression of a particular disease - causing gene being inhibited.

We hope our content will be of particular interest to industrial or academic scientists active in R&D in molecular biotechnology, gene transfer and expression, applied microbiology, environmental biotechnology, biofuels and bioenergy, nanotechnology, bioprocessing, chemical biotechnology, tissue engineering and regenerative medicine, nucleic acid therapeutics and vaccines, plant biotechnology, and patenting and regulatory issues.

In a general sense, FP timers can be used in any situation where one wants to understand the relationship between the age of a cell, protein, or cellular structure and a particular biological event (trafficking to a subcellular location, start of gene expression, development of a cell structure, etc).

Using the two link buttons on the left, it is possible to further study the gene list of a particular «wave» in the context of publicly available databases, or view the gene expression profiles in ExpressView.

Recent studies of the ES cell transcriptome and epigenome have revealed networks of co-regulated transcription factors that maintain pluripotency and suppress the expression of genes associated with particular differentiation lineages [2].

To better illustrate and map co-regulated genes with different activation and deactivation profiles, the levels of every transcript have been assigned to graphs of «Expression Waves» that follow a particular, predetermined, expression pattern (Expression Waves» that follow a particular, predetermined, expression pattern (expression pattern (Figure 5).

We furthermore show that several of these RNA modifications have a dynamic response to environmental stress and that, in particular, changes in the tRNA wobble base modification 5 - methoxycarbonylmethyl -2-thiouridine (mcm (5) s (2) U) lead to codon - biased gene - expression changes in starved animals.

Schosserer will be spending two months in the laboratory of Aric Rogers, Ph.D., at the MDI Biological Laboratory's Kathryn W. Davis Center for Regenerative Biology and Medicine studying the role that molecular regulators of gene expression play in longevity — and in particular how these regulators are affected by lower amounts of food or food with lower energy content.

This is the first study demonstrating smoking - induced expression changes for this particular set of genes and importantly, it is the first time partial reversibility (MUC5AC) and irreversibility (GSK3B) and has been demonstrated using two different cohorts of samples with two independent assays for expression quantification.

«Dark chocolate, a high source of polyphenols, and flavanols in particular, has lately received attention for its possible role in modulating obesity because of its potential effect on fat and carbohydrate metabolism, as well as on satiety... The research undertaken to date has shown promising results, with the possible implication of cocoa / dark chocolate in the modulation of obesity and body weight through several mechanisms including decreasing the expression of genes involved in fatty acid synthesis, reducing the digestion and absorption of fats and carbohydrates and increasing satiety.»

Within the gene coding for MAOA, there is a particular form of variation (referred to as the MAOA - uVNTR) that is associated with differences in the expression of the MAOA gene (Sabol et al., 1998).

Recent theorizing within this tradition suggests that these shifts may be manifested in changes in the relative frequency of particular cell types in blood (Irwin and Cole, 2011) as well as in the epigenetic programming and gene expression of such cells (Miller et al., 2011a).