Sentences with phrase «expression of the activator»

Plus, the metastatic phenotype may be brought about by extensive combinations of subtle up and down regulations of proteins that activate or suppress other proteins that are normally there, in which case the more interesting observation would be how the expression of the activator and suppressor proteins change.

Not exact matches

Prof. Ruiling Zhang and team from Xinxiang Medical University explored the correlation between cyclin - dependent kinase 5 expression in the hippocampus and neurological impairments following prenatal ethanol exposure, and found that prenatal ethanol exposure could affect cyclin - dependent kinase 5 and its activator p35 in the hippocampus of offspring rats.

Mal - gluc modulates histone acetylation of the Rac1 gene and allows transcription activators to access the DNA for increased transcription in the brain, which influences the expression of genes responsible for synaptic plasticity.

Loss of tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator protein 1 and nuclear factor kappaB induced by UV radiation.

A novel disrupter of telomere silencing 1 - like (DOT1L) interaction is required for signal transducer and activator of transcription 1 (STAT1)- activated gene expression.

Further, we identified a role for ABL kinases in promoting the expression of multiple pro — bone metastasis genes such as AXL (which encodes a receptor tyrosine kinase), IL6 (which encodes interleukin - 6), MMP1 (which encodes matrix metalloproteinase 1), and TNC (which encodes tenascin - C) through TAZ - and signal transducer and activator of transcription 5 (STAT5)-- mediated signaling.

Activators of histone acetyltransferases (HAT) provide an alternative approach for the selective activation of gene expression, however little is known about the potential of HAT activators as drug therapiActivators of histone acetyltransferases (HAT) provide an alternative approach for the selective activation of gene expression, however little is known about the potential of HAT activators as drug therapiactivators as drug therapies for PD.

Surprisingly, small molecule activators of PKA signaling increase expression of Oct4 protein, which in turn enhances expression of a specific subset of Oct4 target genes.

His pioneering work in the fields of gene cloning and expression of human proteins has been the basis for five significant marketed therapeutics developed by Genentech, including human insulin, human growth hormone, interferon - alpha, interferon - gamma and tissue plasminogen activator.

Sirtuin activators, notably resveratrol (which activates both SIRT1 and PGC - 1α, and improves the functioning of the mitochondria) 23 24 have been shown to inhibit gene expression profiles associated with muscle aging and age - related cardiac dysfunction in mice and may extend lifespan.25 26

Curcumin activates PPAR (peroxisome proliferator - activator receptor) which is a group of key nuclear proteins that regulate gene expression and modulate sugar uptake and utilization in the bloodstream.

These NRF2 activators turn on the genes responsible for survival, and the protection within our cells against the damage and inflammation that age your dog and allow the expression of disease states.

Since SP1 is an activator of transcription [45], the deletion of an SP1 site should result in down regulation of gene expression.