Sentences with phrase «expression studies suggested»

To begin to explore the cellular mechanisms that might be responsible for this response, histological analysis revealed less severe disruption of spermatogenesis and gene expression studies suggested that an interplay of ATP - binding cassette (ABC) efflux transporters and solute carrier (SLC) influx transporters in the testicular cells might be involved.

Not exact matches

«Our study suggests that m6A - mediated adjustment of gene expression might be an ancient yet unexplored mechanism for the development of this diversity.»

This study, published in the journal Microarrays, shows that lack of SOST in the bone microenvironment promotes the expression of many genes associated with cell migration and / or invasion, including long non-coding RNA MALAT1 in prostate cancer, suggesting that SOST has an inhibitory effect on prostate cancer invasion.

Studies in the mouse model further suggest that controlled expression of Lin28 can promote kidney development and therefore may hold clues to regeneration of damaged kidneys in adults.

Animal studies have suggested that overactivation of TLR7 plays a role in lupus, and a gene variant that increases expression of the receptor has been associated with increased lupus risk in human patients.

And more recently, molecular studies had suggested that caloric restriction — or compounds that mimicked it — might trigger a cascade of changes in gene expression that had the net effect of slowing ageing.

These studies suggest that social intelligence depends on more than knowing specific social rules or having certain social abilities, like the ability to read people's facial expressions.

Other studies suggest that the ultrasonic squeaks they make are expressions of pleasure.

The study suggests that methods based on variance may help get the most from existing and future global gene expression studies.

«Our study reveals important differences and specificities in the mechanism of action of high - and low - dose aspirin in metastatic and nonmetastatic cancer cells with different tumor origins and suggests that the ability of aspirin to prevent platelet - induced c - MYC [an oncoprotein] expression might be selective for a nonmetastatic phenotype.»

Commenting, Jean - Charles Soria notes: «This study suggests that PDL1 expression is correlated with EGFR mutation.

«These findings suggest that focusing on genes with conserved expression levels among primates may be helpful in identifying promising candidates for disease - association studies,» the researchers write.

Encouraged by the study results, the team suggests that it may now be technologically possible to screen for cancer by checking expression levels of bronchial airway cell genes.

The fist - pumping, chest - swelling, grimacing roar that an Olympic judo player emits after body - slamming his opponent deserves a spot on the list of universally recognized expressions such as anger and happiness, a new study suggests.

A few studies have suggested that CA2 might be involved in social memory, as this region has a high level of expression of a receptor for vasopressin, a hormone linked to sexual motivation, bonding, and other social behaviors.

For decades, there have been studies suggesting that human babies are capable of imitating facial gestures, hand gestures, facial expressions, or vocal sounds right from their first weeks of life after birth.

«This study suggests that targeting p27, GATA3 and POU4F3 may enhance the outcome of gene therapy and other approaches that aim to restart ATOH1 expression,» Zuo said.

Our studies suggest that the expression of Hox proteins constitutes another cryptic set of prepatterns.

Here we suggest a novel yet conceptually simple approach for deriving «Functional Association (s) by Response Overlap» (FARO) between microarray gene expression studies.

«Our results suggest that neuropsychiatric CNVs can be used as an instrument for further study of the cognitive abnormalities that characterize schizophrenia, because whether or not an individual develops this disease is likely related to the expression of these genes,» said Stefansson.

Several retrospective studies have suggested a correlation between pSTAT3 expression in colorectal cancer and poor survival.

Dr Gilchrist said: «This study suggests that we may improve significantly on the widely used analysis methods for determining gene expression levels from high throughput sequence data: absolute quantitation offers a much sounder basis for determining changes in gene expression level, a measure widely used to determine the consequence of genetic, chemical or physical disturbances in living systems.»

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

However, recent studies have suggested that STAT signaling is more complicated than originally thought, and unphosphorylated STATs are also able to regulate gene expression.

Together these studies suggest that Punc - 7S drives expression of UNC - 7S in a subset of neurons (including AVA and AVB, but not motor neurons) that can effect rescue of forward locomotion, and promoter sequences upstream of exon 2 drive additional expression of UNC - 7S in motor neurons or possibly other neurons required to fully rescue all unc - 7 locomotory defects.

Bethesda, Md. (April 3, 2018)-- A new study suggests that resistance exercise may improve indicators of type 2 diabetes by increasing expression of a protein that regulates blood sugar (glucose) absorption in the body.

A more recent study showed overlapping expression of nanog with GATA - 6 and a Pdgfra reporter, markers of the primitive endoderm lineage, from the morula to the 64 cell stages [8], suggesting a gradual transition from a pluripotency program to a committed state.

«Our study suggests a therapeutic benefit for repurposing a well - tolerated inhibitor with limited toxicity to treat a specific group of ovarian cancer patients with high levels of CARM1 expression,» said Sergey Karakashev, Ph.D., first author of the study and a postdoctoral researcher in the Zhang Lab.

Our biological studies suggest that a critically reduced amount of this protein alters cell shape, migration, proliferation, and gene expression to the detriment of brain, heart, and kidney development.

However, recent evidence indicates that apoE4 expression compromises the blood - brain barrier (as does apoE deficiency).40 Studies of brain histology, neurodegenerative markers, cholinergic activity, and neuronal function in knockout mice have been equivocal.39 Failure of detailed neurocognitive and retinal studies to demonstrate defects in our patient suggests either that the functions of apoE in the brain and eye are not critical or that they can be fulfilled by a surrogate pStudies of brain histology, neurodegenerative markers, cholinergic activity, and neuronal function in knockout mice have been equivocal.39 Failure of detailed neurocognitive and retinal studies to demonstrate defects in our patient suggests either that the functions of apoE in the brain and eye are not critical or that they can be fulfilled by a surrogate pstudies to demonstrate defects in our patient suggests either that the functions of apoE in the brain and eye are not critical or that they can be fulfilled by a surrogate protein.

Accumulating data suggests that IER may also activate hormesis, and there has been some suggestion that it is thestress associated with fasting, or the alternating periods of anabolism and catabolism, rather than an overall ER is responsible.15, 105 IER (100 % ER / alternate days) in rodent studies has been shown to up - regulate the expression ofanti - oxidative 20, 105, anti-apoptotic 20, 21 and pro-angiogenic 21 factors.

A small Norwegian study suggested that yoga's many healthy benefits might come from its ability to alter gene expression in immune cells.

New research studies suggest that intermittent fasting helps optimize insulin levels, promote weight loss, facilitate cellular repair and even control gene expression to promote longevity and disease protection.

The significance of detox becomes apparent when you understand that our main liver detox gene, P450, has been crippling by the industrial seed oils ubiquitous in the food system thus hindering our ability to detox; recent studies have found that soybean oil, canola oil (and vegetable oils as they typically contain soybean / canola oil) significantly affect the expression of many genes that metabolize drugs and other foreign compounds that enter the body, suggesting that a soybean oil - enriched diet could affect one's response to drugs and environmental toxicants.

Our study suggests that B. fragilis is able to ameliorate leaky gut by directly targeting tight junction expression, cytokine production and / or microbiome composition.

«These results suggest that Ex-miRNA expression changes may be more specific to disease states than total plasma miRNA,» said Andy Hoffman, DVM, Ph.D., professor and director of the Regenerative Medicine Laboratory at Cummings School and corresponding author on the study.

Molecular studies have also suggested that ARD is associated with increases in pro-inflammatory cytokine mRNA expression yet without histologic evidence of inflammation.

It is no surprise to find gender differences, since other studies have suggested that women are more sensitive to emotional expression than men.

Together, they are like a sheet of drawings by an old master, a study in facial expressions that suggests a range of experiences, from the ecstatic to the infernal.

Suggesting genetics and the resulting social environment in which kids are raised may be more to blame than anything.Parents of Autistic Children Show Similar TraitsThe study, conducted by the California Institute of Technology looked at how parents of autistic children evaluated facial expressions and found that they gauged faces in exactly the same way as people with the disorder, despite the fact that they were not classified as autistic themselves.

The study's author suggests various theories for the decline in the success rate, including that courts are seeking to give greater protection to freedom of expression; during the 2003 - 13 period, plaintiffs were far more successful in cases involving «new media» (email or internet), with a 62 % success rate (more than double the success rate for cases between 2003 - 13 considered as a whole).

Some heterosexual women report kissing other women as part of the college social scene or for men's attention, while others do so to experiment or explore potential same - sex desires.1 A 2012 study found that both women and men perceive women who kiss other women in heterosexual spaces (for example, bars that heterosexual individuals frequent) as more promiscuous than those who kiss a man, and that women and men perceive such women as more likely to be heterosexual than bisexual or lesbian.2 In some ways, this last finding may suggest that women and men do not always perceive female - female kissing as necessarily an expression of women's same - sex desire.

Studies suggest that non-genetic, environmental, infectious, or psychosocial factors — while not causing Tourette's — can impact upon the expression of the severity of the disorder.

Furthermore, animal studies suggest that harsh parenting affects the expression of genes by epigenetic processes.

The findings from these studies converge to suggest that the mothers of children with high levels of CU traits have a more negative emotion socialization style, characterized by less acceptance and more dismissing of children's experience and expression of emotions.

This study suggests that adolescents exposed to family violence learn anger expression styles that put them at risk of being perpetrators of dating violence.