Sentences with phrase «extended gene models»

Sequence of the extended gene models for the OR repertoire.

Extended gene models for the VR repertoire.

Extended gene models for the OR repertoire.

Sequence of the extended gene models for the VR repertoire.

The generation of RNAseq data for a majority of ORs and VRs enabled us to obtain new, significantly extended gene models.

Not exact matches

Therefore, using the model plant Arabidopsis, they extended the expression time of WRI1, a gene that activates oil synthesis.

The current JBMR study extended that research by using palovarotene in a mouse model carrying the same human gene mutation that causes FOP.

Drs. Martinez - Agosto and Ferguson and colleagues next hope that future studies will examine these genes beyond Drosophila and extend to mammalian models, and that the system will be used by the research community to study the role of the genes Yorkie and Scalloped in different niche environments.

Modeling gene expression evolution with an extended Ornstein — Uhlenbeck process accounting for within - species variation Rohlfs, R. V., P. Harrigan and R. Nielsen.

Furthermore, we have validated and extended the conclusions of our model system with a detailed analysis of Î ± 2 integrin gene expression and its significance in human breast and prostate cancer.

Extending these results into rodent models of H. pylori - induced inflammation and carcinogenesis (Mongolian gerbils and mice), we have shown that inactivation of such genes attenuates the development gastric injury and cancer.

We find a large increase in the proportion of unique sequence in our new extended V1R (P < 0.0001, Mann Whitney test) and V2R gene models (P < 0.0001, Mann Whitney test); a more modest increase is apparent in OR genes (P = 0.044, Mann Whitney test; Figure 7D).

In mouse models in which the endogenous Smn1 gene has been knocked out and human versions of SMN2 have been swapped in, the Isis therapy — a so - called «antisense oligonucleotide» — delivered to the mouse central nervous system (CNS) increased the expression of full - length SMN protein in motor neurons, improved muscle strength in behavioral tests and extended the rodents» median lifespan from 16 days to 26 days3.

We sequenced at sufficient depth to produce new, extended receptor gene models for 913 (73.1 %) OR and 246 (45.9 %) VR genes (the models and their sequences are provided in Datasets S4, S5, S6, S7).

We plan to extend this discovery by developing a model of TBK1 glaucoma that will facilitate studies of the basic mechanisms by which defects in genes cause the disease.

It was assumed that if the data sets had a normal residual distribution when fitting the polygenic models, normality was maintained when the models were extended to include the major gene effects.