Not exact matches
The enzyme, called tankyrase, may prove useful for
extending the lives of cultured
cells grown to
repair burned skin and other damaged tissue.
PER2: Deletion of the PER2 gene in mice, associated with the mechanisms of circadian rhythm, appears to improve DNA
repair in stem
cell populations relevant to the immune system, resulting in a healhier immune
cell population, better immune function in old age, and a modestly
extended life span.
Mitochondrial Complex I: Partial disruption of the function of mitochondrial complex I has been shown to modestly
extend life in a number of species, with the dominant theory being that this is a hormetic effect - an increase in the creation of reactive oxygen species prompts
cells to react with greater
repair and maintenance efforts.
The good news is that replenishing NAD + to
cells can restore DNA
repair and prevent
cell death under stress.26, 29 In two different animal models of neurodegenerative disease, increasing cellular NAD + reduced the severity of the disorder, normalized neuromuscular function, delayed memory loss, and
extended lifespan.30