It should be noted, however, that while a study on senescent
cell ablation in genetically
normal mice would provide at least some evidence on the effect of senescent
cells (and their ablation) on promoting cancer, even such a study would likely show less effect
than could be anticipated in a large mammal model, since even normally - aging mice rarely suffer metastatic disease to the
extent of aging humans, as sheer primary tumor volume is generally sufficient to be fatal to mice.