Sentences with phrase «extra-embryonic endoderm»

Bona fide trophoblast stem cell lines and extra-embryonic endoderm stem cells can be directly derived from expanded potential stem cells in vitro.

The epiblast is the source of all embryonic tissue and the PrEn the source of both extra-embryonic endoderm lineages, visceral and parietal.

However, when challenged to differentiate immediately after purification, each exhibits strong lineage bias, with the endoderm marker - expressing fraction unexpectedly able to contribute to the extra-embryonic endoderm in chimeric embryos.

Taken together our data support the notion that the reversible and immediate early PrEn state marked by low - level transcription at the Hex locus is biased towards the formation of extra-embryonic endoderm.

Not exact matches

Within this elementary biological structure, three types of cells begin to cluster and develop: the embryonic stem cells (which eventually become the body of the embryo), and two extra-embryonic types of cells - the trophoblast stem cells (which develop into the placenta) and the endoderm stem cells (which go on to form the yolk sac).

Most strikingly when introduced back into morulae or blastocysts, the V+S + population is not effective at contributing to the epiblast and can contribute to the extra-embryonic visceral and parietal endoderm, while the V − S + population generates high contribution chimeras.

In support of this idea, Beddington and Robertson originally observed ES cell contribution to all the extra-embryonic lineages, but in particular to parietal endoderm [23].

Mouse embryonic stem cells derived from the epiblast contribute to the somatic lineages and the germline but are excluded from the extra-embryonic tissues that are derived from the trophectoderm and the primitive endoderm upon reintroduction to the blastocyst.