First off, all of this new research on the role of the helper complex and mTOR in making
extra-long huntingtin protein was done in cells or mice.
The more we understand about how the normal and
extra-long huntingtin proteins are made and work in brain cells, the better equipped we'll be in the search for HD treatments.
Not exact matches
It's the
extra-long copy of the
huntingtin gene that makes neurons sick, because it causes them to produce an
extra-long, harmful version of the
huntingtin protein.
In HD, a repeated sequence of letters in this gene leads to an
extra-long form of
huntingtin protein that can wreak havoc in brain cells over long periods of time.
As expected, they found that the normal and
extra-long genetic instructions were both translated into
huntingtin proteins when they met up with a ribosome (the chef from our analogy above).