Sentences with phrase «extracellular ligands»

To sense extracellular ligands, we targeted the computational re-designed PBPs to the apoplast.

In our system, plants sense and then respond to pM - µM levels of the extracellular ligand.

Not exact matches

The new research finds that the stiffness of the extracellular matrix and the availability of certain ligands (molecules that bind to cell membranes) can together determine which genes are actually called on — and whether normal epithelial cells begin to exhibit the behaviors characteristic of highly malignant cancer cells.

After ligand binding, the extracellular portion loses flexibility while the intracellular portion gains it.

The «rotation model» Ligand binding to the extracellular part of the receptor induces rotation of the receptor's transmembrane region inside the cell membrane, and in doing so, regulates its activity inside the cell.

Fertilization in humans is initiated by binding of spermatozoa to a selectin ligand on the egg's extracellular matrix.

Extracellular protein disulfide isomerase regulates ligand - binding activity of αMβ2 integrin and neutrophil recruitment during vascular inflammation.

Eph receptor and ephrin ligand signalling has been implicated in vascular development and in in vivo models of angiogenesis where bi-directional signalling mediates juxtracrine cell — cell contact, cell adhesion to extracellular matrix and cell migration30, 31,32.

Current techniques used to investigate the effects of extracellular matrix ligand presentation on cell functions work by independently manipulating variables like ligand density, clustering and spacing [3 — 5].

NG2 - positive smooth muscle cells and several NG2 - positive cell lines also proliferate and migrate well in response to soluble type VI collagen, an extracellular matrix ligand for the proteoglycan.

PBPs bind the ligand and develop affinity for the extracellular domain of a chemotactic protein, Trg.