Unfortunately, 40 percent of dogs diagnosed with glaucoma suffer blindness and
eye degeneration within the first year.
Not exact matches
We seek to determine whether a particular type of imaging, known as «polarization - sensitive» imaging, is capable of reporting on the integrity of sub-microscopic structures
within optic nerve fibers at an early stage of damage from glaucoma, preceding their complete
degeneration and loss from the
eye.
We seek in this proposal to determine whether a particular type of imaging is capable of assessing and reporting on the integrity of sub-microscopic structures
within optic nerve fibers at an early stage of damage preceding their complete
degeneration and loss from the
eye.
The goals of this project are (i) to improve a mouse model of macular
degeneration, and (ii) to test a genetically modified virus that can control inflammation
within the
eye of this mouse model.
In dogs affected with PLL ultrastructural abnormalities of the zonular fibers are already evident at 20 months of age [120] long before the lens luxation that typically occurs when the dogs are 3 to 8 years old, as a result of
degeneration and breakdown of the zonules which cause the lens to be displaced from its normal position
within the
eye [121 — 124].