However, when forced to express
the eye field transcription factor (EFTF) genes, the cells differentiate into all seven retinal cell classes and eventually organize themselves into a functioning eye that can detect light and guide tadpoles in a vision - based behavior.
A group of transcription factors collectively called
the eye field transcription factors or EFTFs (pax6, rx1, tbx3 [or ET], nr2e1 [or tailless], six3, lhx2, and six6 [or optx2]-RRB- and the neural patterning gene otx2 are essential for normal eye formation [6].
Abbreviations: BrdU, 5 - bromo -2-deoxyuridine; CMZ, ciliary marginal zone; EFTF,
eye field transcription factor; ERG, electroretinogram; GABA, gamma - aminobutyric acid; LE, lateral endoderm; N, number of animals or eyes; PNP, posterior neural plate; RPE, retinal pigment epithelium; YFP, yellow fluorescent protein