The
fact that IGF - 2 is naturally occurring and can
cross the
blood -
brain barrier makes it a promising candidate for treating memory - impairing diseases or even forgetfulness, Alberini notes.
The age - related decline in growth hormone and associated IGF - 1 has been linked to age - related muscle atrophy, increased adipose tissue, and neuronal dysfunction.2, 9 In
fact, growth hormone replacement therapy in elderly men has been shown to increase lean body mass.9 Growth hormone therapy (1 mg / day — for 5 months) has also been used to improve cognitive function in healthy adults and adults with mild cognitive impairment.10 While only modest amounts of growth hormone
cross the
blood -
brain barrier, IGF - 1, which is actually responsible for the cognitive benefits, gets across just fine.