Sentences with phrase «factor lif»

«The key was the use of the humoral factor LIF.

Not exact matches

In a study in the current issue of the Journal of Neuromuscular Diseases, researchers treated these stem cells with leukemia inhibitory factor (LIF), which effectively maintained the undifferentiated state of the satellite cells and enhanced their transplantation efficiency.

A growth factor called LIF tripled the number of oRG cells in growing minibrains by week 12.

Leukemia inhibitory factor (LIF): Altered LIF levels have been used to spur neural cells into greater activity that can better restore lost myelin sheathing on nerves.

We are particularly interested in the role of the transcription factor Nanog, which we isolated through a functional screen for molecules capable of directing ES cell self - renewal in the absence of the otherwise obligatory LIF signal.

Title: Oct4 and LIF / Stat3 Additively Induce Krüppel Factors to Sustain Embryonic Stem Cell Self - Renewal Authors: Hall J, Guo G, Wray J, Eyres I, Nichols J, Grotewold L, Morfopoulou S, Humphreys P, Mansfield W, Walker R, Tomlinson S, Smith AG Date: 2009 Publication Details: Cell Stem Cell.

Using NPCs, Silva et al. delineated two phases in the reprogramming process (pre-pluripotency and ground state pluripotency) and demonstrated that dual inhibition (2i) of mitogen - activated protein kinase (MAKP) signaling and glycogen synthase kinase - 3 (GSK3) signaling combined with the self - renewal cytokine leukemia inhibitory factor (LIF) promotes pre-pluripotent cells to ground state pluripotency [19].

Most prior established iPS cell lines were derived and maintained on mouse embryonic fibroblast (MEF) cells supplemented with exogenous leukemia inhibitory factor (LIF).

In vitro, ES cells can generate PrEn - like cells either in response to LIF withdrawal [24] or through forced expression of the transcription factors Gata4 or Gata6 [25], [26].

For measuring the effect of TNFα on NSCs, I6 NSCs were passaged onto fibronectin - coated 4 - well plates in Neurobasal media supplemented with 1X B27, 2 mM L - glutamine and 10 ng / ml of both bFGF and LIF growth factors.

Briefly, ES cells were kept in standard ES cell medium containing leukemia inhibitory factor (LIF) which prevents cell differentiation.

Likewise, it has been shown that signaling pathways and transactivation potentials triggered by extracellular stimuli such as BMPs, LIF, and other factors play major regulatory roles (for review see [1], [2]-RRB-.