Sentences with phrase «factor tbp»

In addition, the total amount of a protein can be regulated by alternative splicing, which is illustrated in the current work by using the general transcription factor TBP (TATA - box binding protein) as an example.

Not exact matches

We previously defined Saccharomyces cerevisiae TFIID as a 15 - subunit complex comprised of the TATA binding protein (TBP) and 14 distinct TBP - associated factors (TAFs).

Specifically, we have shown that the condensin subunit Cnd2 binds directly to the most important general transcription factor, the TATA box - binding protein TBP, and that TBP recruits condensin molecules onto RNA polymerase III - transcribed genes and highly active Pol II - transcribed genes (many ribosomal protein genes) through the Cnd2 - TBP interaction (Figure A).

We found that the interaction between two classic factors, condensin and TBP, plays a pivotal role in 3D chromosome organization, and ensures that a critical set of genes, the actively transcribed housekeeping genes, are accurately segregated during mitosis (Figure B and C).