Sentences with phrase «factor expression in»

Over the course of seven days, researchers showed that doses of both 50 and 100 mg / kg of saponins extracted from Asian ginseng exerted significant antidepressant effects, presumably by reversing neurotrophic factor expression in the hippocampus.

Taylor, S.L., Stanek, L.M., Ressler, K.J., and Huhman, K.L. Differential brain - derived neurotrophic factor expression in limbic brain regions following social defeat or territorial aggression.

Not exact matches

Whitehead's endeavors to resolve questions of becoming began with physical nature as a frame of reference and an event as the primary datum in the construction, functioning, and form of nature, with the time factor of space - time constituting one of the major expressions of the relation between events.

Should, as the authors fear, the expression of a single factor prove insufficient to promote the direct formation of pluripotent stem cells there are multiple other factors to try» either singly or in combination.

It may be that Kelley had «domestic issues», or «mental health» issues, or other factors (as is so often the case, real life stories are usually far more complex than the 24 hour / 24 second sound bite culture we live in) and that his expressions of hatred against Christianity were only secondary factors, if factors at all.

The survey bears out that the caliber of leadership is a far more determinative factor in church growth than questions of liberal - versus - conservative positions, or social action versus personal - individual religious experience and expression.

Expression of functional immunomodulatory and anti-inflammatory factors in human milk.

Most of the commonly occurring cancers, notably breast, prostate, and lung cancer, spread (metastasize) to bone; I was set to the task of studying the role of a transcription factor (gene - expression regulator), NF B (nuclear factor kappa B), in cancer metastasis.

Reprogramming involves inducing the expression of four factors, called Yamanaka factors, in cells.

The team induced expression of Yamanaka factors in all cells of the organism using their partial reprogramming approach.

Drosha degrades the messenger RNA for NFIB in the adult hippocampal stem cells and prevents the expression of this transcription factor which is necessary for the differentiation of oligodendrocytes and thus blocks their development and therefore biases differentiation towards neurons.

«But we know that the expression of these factors is inducing changes in the epigenome, and those are leading to benefits at the cellular and organismal level.»

Traditional strain - selection techniques are supplemented with strain screening, which can involve examining gene - expression patterns through PCR or understanding global gene expression in relation to environmental factors using gene chips.

Transcription factors are responsible for either inhibiting or promoting the expression of genes, and master regulatory transcription factors are like transcription factors on steroids: their actions regulate thousands of genes in different kinds of cells.

Their presentation is entitled «High expression of AF1q is an adverse prognostic factor and a prediction marker of extramedullary disease in multiple myeloma.»

In a paper publishing August 7th in the Open Access journal PLOS Biology, researchers at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI - CBG) succeeded in mimicking the sustained expression of the transcription factor Pax6 as seen in the developing human brain, in mouse cortical progenitor cellIn a paper publishing August 7th in the Open Access journal PLOS Biology, researchers at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI - CBG) succeeded in mimicking the sustained expression of the transcription factor Pax6 as seen in the developing human brain, in mouse cortical progenitor cellin the Open Access journal PLOS Biology, researchers at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI - CBG) succeeded in mimicking the sustained expression of the transcription factor Pax6 as seen in the developing human brain, in mouse cortical progenitor cellin mimicking the sustained expression of the transcription factor Pax6 as seen in the developing human brain, in mouse cortical progenitor cellin the developing human brain, in mouse cortical progenitor cellin mouse cortical progenitor cells.

This chimera, created by a team at the Georgia Cancer Center, has the ability to simultaneously decrease the expression of three growth factors that are over-expressed in some cancers.

According to Dr. Schwarz, «We observed acute proinflammatory changes, namely, leukocytosis, neutrophilia, upregulated levels of IL - 6 in serum, and enhanced messenger RNA expression of IL - 6 and tumor necrosis factor alpha.

SIX3 and a related gene, SIX2, with a similar pattern of expression in human beta cells, encode proteins known as transcription factors that control the expression of many other genes in the cell.

Hockemeyer says that it's unlikely to be another mutation, but rather an epigenetic change that affects expression of the telomerase gene, or a change in the expression of a transcription factor or other regulatory proteins that binds to the promoter upstream of the telomerase gene.

«The 20 - year difference in expression of the gene abnormality shows the devastating consequences of recent environmental factors, such as eating high - glycaemic foods and a lack of exercise,» Froguel says.

Such transient effects of environmental factors to which earlier generations were exposed on the expression of characteristics in their progeny illustrate the unique, pliable nature of this epigenetic mechanism.

The researchers found that the blond hair commonly seen in Northern Europeans is caused by a single change in the DNA that regulates the expression of a gene that encodes a protein called KITLG, also known as stem cell factor.

The researchers investigated 16 groups of female and male mice offspring exposed to maternal diet - induced obesity and male hormone excess and studied how these environmental factors affected the mice's behaviour as well as gene expression in the brain.

The environmental factors also affected gene expression in the brain.

Each cell type can be distinguished based on its transcription factors, and a cell can in certain cases be directly converted from one type to another, simply by changing the expression of one or more transcription factors.

To see whether Lin28 might be a factor in Wilms tumor development, Daley and an international team of collaborators measured the gene's expression in tumor samples from 105 Wilms patients.

In nonmutant mice, they found that the protein complex composed of Cbf - beta and the Runx2 transcription factor binds to the Wnt10b promoter to drive Wnt10b expression.

A group of cells releases a factor, which changes gene expression in a related group of cells.

When a strain of mice genetically destined to develop a form of TLR7 - dependent lupus was crossbred with a strain in which TREML4 expression was suppressed, offspring lacking TREML4 were protected from the development of lupus - associated kidney failure and had significantly lower blood levels of inflammatory factors and autoantibodies than did mice expressing TREML4.

In the last 15 years, researchers worldwide have generated a large amount of information about the epigenome: proteins, factors and epigenetic markers which, when bound to DNA, regulate gene expression.

«We have shown that the synthesis of nitric oxide (NO), known to regulate gut motility functions and NRF2, a transcriptional factor known to regulate several antioxidant genes, mediated Phase II protein expression have been altered in colon specimens of polybacterialinfected ApoE - / - mice,» said Miriam Walker.

They found higher levels of JAK1 in resistant tumors, which caused increased expression of epidermal growth factor receptor (EGFR)-- a receptor tyrosine kinase that promotes cell proliferation.

Association of a protein biomarker with any given disease process, for example, needs to be assessed in terms of disease - independent, confounding factors that may modulate protein expression levels among different individuals.

«A lot of diabetes in the elderly goes undiagnosed because they don't have the classical risk factors for type 2 diabetes, such as obesity,» says Evans, director of Salk's Gene Expression Laboratory and senior author of the new paper, which was published November 18, 2015 in Nature.

By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light - inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.

One hypothesis for why females in many animal species frequently prefer to mate with the most elaborately ornamented males predicts that availability of carotenoid pigments is a potentially limiting factor for both ornament expression and immune function.

In the current paper, knowing that MYC, a transcription factor that binds the genome through sites that are identical to the binding sites of BMAL1, the team hypothesized that aberrant MYC expression perturbs the clock by deregulating components of the circadian network in cancer cellIn the current paper, knowing that MYC, a transcription factor that binds the genome through sites that are identical to the binding sites of BMAL1, the team hypothesized that aberrant MYC expression perturbs the clock by deregulating components of the circadian network in cancer cellin cancer cells.

In the hippocampus, a major component responsible for memory, neural activity, synapse formation and expression of brain - derived neurotrophic factor (BDNF) were reduced in these mice (Image 2In the hippocampus, a major component responsible for memory, neural activity, synapse formation and expression of brain - derived neurotrophic factor (BDNF) were reduced in these mice (Image 2in these mice (Image 2).

«In Rejlander, Darwin found a photographer who was capable of manipulating his results to fit specific needs... His ability to concoct pictures using a mixture of natural and artificial elements proved to be a deciding factor in the completion of Expression,» Prodger writeIn Rejlander, Darwin found a photographer who was capable of manipulating his results to fit specific needs... His ability to concoct pictures using a mixture of natural and artificial elements proved to be a deciding factor in the completion of Expression,» Prodger writein the completion of Expression,» Prodger writes.

KLF4 together with other reprogramming transcription factors is used in the lab to force the expression of genes in somatic cells (adult non-germline cells) in the development of iPSCs.

«Many thyroid diseases will be impacted by changing the expression levels of the thyroid - specific transcription factor, so we want to investigate FOXE1 more carefully in future work.»

Earlier work Weimbs conducted at UCSB had shown that the transcription factor called STAT6 is overly active in PKD, and he also recalled that STAT6 had been shown to drive the expression of pIgR in other organs.

It is situated just next to a thyroid - specific transcription factor, a protein that regulates the rate of gene expression in the thyroid.

It does so by activating the transcription factor STAT3, which in turn inhibits expression of the miR - 34a gene by directly binding to it.»

In these images of rat brains, differences in gene expression of genes for fibroblast growth factor 2 (FGF2, top set) and dopamine 2 receptor (D2, bottom sett) can be seen in rats of two breeds before (left) and after (right) cocaine exposurIn these images of rat brains, differences in gene expression of genes for fibroblast growth factor 2 (FGF2, top set) and dopamine 2 receptor (D2, bottom sett) can be seen in rats of two breeds before (left) and after (right) cocaine exposurin gene expression of genes for fibroblast growth factor 2 (FGF2, top set) and dopamine 2 receptor (D2, bottom sett) can be seen in rats of two breeds before (left) and after (right) cocaine exposurin rats of two breeds before (left) and after (right) cocaine exposure.

Disregarding the problem of disguises, face - recognition programs can be thrown off by factors such as changes in hair and facial hair, different expressions, and aging.

They also found no increase in the levels of angiogenesis - inducing factors or in the expression of angiogenesis - related genes in metastatic lymph nodes.

Many factors are involved in controlling which genes get transcribed into messenger RNA and when, but RNA binding proteins interact with the messenger RNA itself to regulate gene expression after transcription has occurred.

Several research groups are pursuing gene therapy approaches to regenerate skin, such as using genes to control expression of growth factors involved in skin healing.