Amphimedon lacks Hox genes and some other transcription
factor subfamilies that are involved in specifying and patterning bilaterian nervous systems and body plans13, 14,27,36,37.
Here, we report that capsaicin has a cocarcinogenic effect on 12 - O - tetradecanoylphorbol -13-acetate (TPA)-- promoted skin carcinogenesis in vivo and is mediated through the epidermal growth
factor receptor (EGFR), but not the transient receptor potential vanilloid
subfamily member 1 (TRPV1).