Sentences with phrase «factors leading to result»

Not exact matches

But it's important to note that these results were from observational studies of healthy adults, and there could still be plenty of confounding factors that lead to dementia.

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

As a result, they've found 40 distinct factors that they say are statistically shown to lead to happier employees who are more likely to stick around, and where marginalized groups are more likely to reach parity.

Actual results, including with respect to our targets and prospects, could differ materially due to a number of factors, including the risk that we may not obtain sufficient orders to achieve our targeted revenues; price competition in key markets; the risk that we or our channel partners are not able to develop and expand customer bases and accurately anticipate demand from end customers, which can result in increased inventory and reduced orders as we experience wide fluctuations in supply and demand; the risk that our commercial Lighting Products results will continue to suffer if new issues arise regarding issues related to product quality for this business; the risk that we may experience production difficulties that preclude us from shipping sufficient quantities to meet customer orders or that result in higher production costs and lower margins; our ability to lower costs; the risk that our results will suffer if we are unable to balance fluctuations in customer demand and capacity, including bringing on additional capacity on a timely basis to meet customer demand; the risk that longer manufacturing lead times may cause customers to fulfill their orders with a competitor's products instead; the risk that the economic and political uncertainty caused by the proposed tariffs by the United States on Chinese goods, and any corresponding Chinese tariffs in response, may negatively impact demand for our products; product mix; risks associated with the ramp - up of production of our new products, and our entry into new business channels different from those in which we have historically operated; the risk that customers do not maintain their favorable perception of our brand and products, resulting in lower demand for our products; the risk that our products fail to perform or fail to meet customer requirements or expectations, resulting in significant additional costs, including costs associated with warranty returns or the potential recall of our products; ongoing uncertainty in global economic conditions, infrastructure development or customer demand that could negatively affect product demand, collectability of receivables and other related matters as consumers and businesses may defer purchases or payments, or default on payments; risks resulting from the concentration of our business among few customers, including the risk that customers may reduce or cancel orders or fail to honor purchase commitments; the risk that we are not able to enter into acceptable contractual arrangements with the significant customers of the acquired Infineon RF Power business or otherwise not fully realize anticipated benefits of the transaction; the risk that retail customers may alter promotional pricing, increase promotion of a competitor's products over our products or reduce their inventory levels, all of which could negatively affect product demand; the risk that our investments may experience periods of significant stock price volatility causing us to recognize fair value losses on our investment; the risk posed by managing an increasingly complex supply chain that has the ability to supply a sufficient quantity of raw materials, subsystems and finished products with the required specifications and quality; the risk we may be required to record a significant charge to earnings if our goodwill or amortizable assets become impaired; risks relating to confidential information theft or misuse, including through cyber-attacks or cyber intrusion; our ability to complete development and commercialization of products under development, such as our pipeline of Wolfspeed products, improved LED chips, LED components, and LED lighting products risks related to our multi-year warranty periods for LED lighting products; risks associated with acquisitions, divestitures, joint ventures or investments generally; the rapid development of new technology and competing products that may impair demand or render our products obsolete; the potential lack of customer acceptance for our products; risks associated with ongoing litigation; and other factors discussed in our filings with the Securities and Exchange Commission (SEC), including our report on Form 10 - K for the fiscal year ended June 25, 2017, and subsequent reports filed with the SEC.

Conversion rates — the rate at which keywords leading to your site result in sales, signups, or whatever your call to action points to — are another important factor in whether your keyword rankings are worth it.

Combining this with poor sales growth results in a dismal outlook for earnings 3) the pressure on earnings will continue to hurt capital spending, which is usually just a magnified image of earnings, 4) the same factors will continue to raise default rates, causing earnings problems and debt downgrades among banks and financial companies, 5) earnings shortfalls will also lead to continued job cutbacks, with the unemployment rate rising to at least 5.5 % (indeed, once the unemployment rate has advanced by 0.5 % from its lows, it has never reversed until rising by least 1.5 % off those lows).

If you approach link building carefully, with an understanding of the factors that will lead you to success instead of penalty, you should be able to avoid any resulting unpleasantness.

Setting aside my personal — and legally irrelevant — disgust at the idea (the «yuck factor,» as one evangelical leader infamously dubbed it, is really no sound basis for building our sexual ethics), it seems that the typical objection to such relationships is that they might lead to congenital problems in any offspring that result from the union.

The 54 - year - old Downton Abbey actor travelled through Jerusalem for the American documentary, Jesus: Countdown to Calvary, speaking with academic experts and spiritual leaders to «deconstruct the week leading up to Jesus» death and untangle the complex factors that resulted in his crucifixion».

«Factors such as public awareness regarding the increase in obesity levels, as a result of high meat consumption, have led to the demand for meat substitutes,» the report said.

[2] «The reluctance to report concussion symptoms and to follow protocols [were] likely results from certain cultural factors such as athletes asserting their masculinity by playing through the discomfort of an injury, and a belief that winning is more important than an athlete's long - term health,» said lead author, Paul Echlin, M.D..

Subsequently, by virtue of defining that an adult and infant are unable to safely sleep on the same surface together, such as what occurs during bedsharing, even when all known adverse bedsharing risk factors are absent and safe bedsharing practices involving breastfeeding mothers are followed, an infant that dies while sharing a sleeping surface with his / her mother is labeled a SUID, and not SIDS.26 In this way the infant death statistics increasingly supplement the idea that bedsharing is inherently and always hazardous and lend credence, artificially, to the belief that under no circumstance can a mother, breastfeeding or not, safely care for, or protect her infant if asleep together in a bed.27 The legitimacy of such a sweeping inference is highly problematic, we argue, in light of the fact that when careful and complete examination of death scenes, the results revealed that 99 % of bedsharing deaths could be explained by the presence of at least one and usually multiple independent risk factors for SIDS such as maternal smoking, prone infant sleep, use of alcohol and / or drugs by the bedsharing adults.28 Moreover, this new ideology is especially troubling because it leads to condemnations of bedsharing parents that border on charges of being neglectful and / or abusive.

This suppression leads to low estrogen concentrations and anovulation with a resulting period of lactational amenorrhea and, therefore, has been investigated as a potential factor related to EOC development (10).

And though the results as published do not completely rule out the idea that other factors were at play, the ad campaign itself seems to have been a deciding factor in defeating a Florida initiative that would have led to larger class sizes in the state's public schools.

Based on the results of the aforementioned report and looking on the most «efficient» regions, the following factors / actions led to higher QoG:

Opponents claimed that it would lead to a poorly co-ordinated economic policy and could potentially lead to conflict in fiscal and monetary policy aims, resulting in particular from an over-emphasis in setting rates to meet inflation targets at the expense of other factors such as the exchange rate.

As a result, it produces certain factors that lead to an infection of the host.

Milovancev notes that future, larger studies that categorize results by factors that might influence tumor - free margin length — such as tumor grade and location — are likely to lead to more refined preoperative surgical planning.

«We chose the basal ganglia because they are primary targets of inflammation in the brain,» says lead author Andrew Miller, MD. «Results from a number of previous studies suggest that increased inflammation may be a contributing factor to fatigue in CFS patients, and may even be the cause in some patients.»

«The explanation is, in brief, that in metals, irradiation produces on picosecond time scales a liquid - like zone, which during the cooling - down phase recombines much of the initially produced damage, leading to a factor of 1/3 reduction in damage,» says Professor Kai Nordlund who was in lead of the team on search for more accurate predictions of usability of materials in nuclear environments, that now present their results freshly in Nature Communications.

The visible differences between us are the cumulative result of genetic, environmental and cultural influences over long periods of time, but rarely do we consider these factors together, which can lead to discrimination on the basis of one or another.

Each document was produced at different moments using a different ink stroke pressure, factors that may alter the results and lead to dating errors.

The research team, which was also led by Dr. Kirsten Beyer of the Medical College of Wisconsin in Milwaukee, adjusted the results to make sure they weren't confounded by race, age, income level, education, marital status, employment and other factors.

The results of the study, published in a research article in the journal Nature Medicine, could lead soon to new treatments for chronic kidney disease that target these risk factors, according to Dr. Jochen Reiser, the senior author of the paper.

«The results indicate that screening guidelines and treatment need to be refined based on individual patient risk factors and genetics,» said lead author Dr. Adam Weiner, a Feinberg urology resident.

Compared to their unmodified counterparts, the growth factors containing the PIGF - 2 sequence resulted in much faster wound closing and production of granulation tissue, and also led to a more pronounced new blood vessel formation, which is essential in sustaining the latter.

While the scientists had been hoping for a eureka moment, the results of their analysis still led them to consider that while space weather isn't a primary driver of strandings, it could be one factor among several.

The POINT trial is important, said Johnston, because genetics, risk factors, and medical practice differences could all lead to differences in trial results in China compared to other countries.

A diet high in saturated fat results in chronic low - grade inflammation in the body that in turn leads to the development of metabolic syndrome, a serious condition associated with cognitive dysfunction and dementia as well as being a major risk factor for cardiovascular disease and type 2 diabetes.

The onset of angiogenesis appears to be the result of an imbalance between stimulatory and inhibitory factors that leads to the activation of previously quiescent endothelial cells (4, 5).

Our results suggest that the lipid - activated transcription factor PPARγ orchestrates a transcriptional response leading to the development of a dendritic cell subtype with increased internalizing capacity, efficient lipid presentation, and augmented potential to activate iNKT cells.

«The results suggest that such «master» regulatory factors could activate regions of the genome that are normally inactive, leading to the formation of organs during development, or the initiation of pathological changes in cells that lead to diseases such as cancer,» Taipale said.

The result is an accumulation of senescent cells, which causes inflammation, tissue degradation and the production of growth factors that alter the tissue microenvironment, leading to disease.

Previous efforts to link Western wildfires with climate change have hinted at a profound relationship but led to unconvincing results, largely because long lists of factors influence ignition and wildfire properties.

As a result, the researchers point out that Factor XII regulation likely won't lead to a cure for Alzheimer's, although it could help scientists develop new early - stage detection strategies and medications to stall the progression of the disease.

However, the study results could lead people with TBI histories to change certain behaviors like alcohol and tobacco use, regular exercise and treating hypertension, diabetes and depression to limit other potential risk factors for dementia.

The researchers indicate that certain lifestyle factors suppress melatonin production, which results in sleep disruption that can lead to weight gain.

The results revealed that postnatal depression is a specific sub group of depression having a distinct genetic element meaning that some women are genetically more prone to the environmental factors that lead to depression.

One theory proposes that once the storage capacity of subcutaneous adipose tissue (SAT) depots is exceeded under conditions of energy excess, either as a result of impaired expandability and / or excessive hypertrophic growth, fat deposition within visceral depots and non-adipose tissues including the liver, skeletal muscle and pancreas can ensue.93 This can subsequently lead to the development of systemic IR and a series of associated cardiometabolic disorders including dyslipidaemia, dysglycaemia, hyperinsulinaemia and hypertension.3 Expression of pro-inflammatory mediators including interleukins 1 (IL - 1), 6 (IL - 6), tumour necrosis factor alpha (TNF - α) and resistin, are also increased which can further potentiate IR and promote atherosclerosis.

We broke down those extreme weight loss success cases and boiled down to five success factors that ultimately lead to a massive result.

It is likely that a combination of several factors (e.g. age - related changes at the level of gene expression, infectious agents, toxic compounds, and head trauma) affects the neuronal milieu and initiates neuropathological processes leading to the formation of toxic tau and amyloid β species, reduction of synaptic plasticity, and neuronal loss resulting in development of sporadic AD.»

Newer fitness trackers like Jawbone's UP3 can even tell you which activities led to your best sleep and what factors resulted in poor sleep.

A previous investigation by Schools Week revealed that the only school - led factor that caused volatility in results linked to swings in GCSE pass rates was moving a large number of pupils into different exams each year.

They say the results of their study suggest arranging seating in a semicircle in primary school «could lead to equal opportunities for everyone in the class» but caution that, when it comes to student participation, factors such as teacher personality and their teaching style shouldn't be ruled out.

The study's findings led researchers to conclude, «this curious result can only mean that VAM results are based on factors other than teachers» actual effectiveness» (Baker et al., 2010, p. 3).

Research has found that the attitudes students take toward learning are heavily influenced by whether they have been led to attribute their success (or failure) to innate ability, to effort, or to other factors — and that traditional classroom practices such as grading and competition lead them to explain the results in terms of ability (or its absence) and to minimize effort whenever possible.

Trading like a sniper is the most significant factor that led to my success in the markets, and as a result, it is one of the most important things I try to drill into my students» heads in my Forex course.

By selecting factors based on implementation characteristics rather than historical returns, we believe these definitions should mitigate (although not eliminate) the backtesting bias discussed by Harvey, Liu, and Zhu (2016) and McLean and Pontiff (forthcoming), as well as result in portfolios with greater liquidity and lower trading costs, leading to higher net returns flowing through to investors.

A favorable outcome in one (or both) of these factors could result in a lower interest rate, leading to thousands of dollars in savings on your student loans.

We judge the leading Canadian stocks on a multitude of factors, with consistently successful results, as you can see when you take a risk - free introductory subscription to The Successful Investor.