Sentences with phrase «failed vaccine trials»

The results came as a surprise to HIV - vaccine skeptics in the AIDS (acquired immunodeficiency syndrome) research field, whose numbers have increased after years of failed vaccine trials.

There are currently no drugs to halt or reverse the spread of Alzheimer's disease, and researchers have tread carefully in the wake of a failed vaccine trial six years ago that was stopped after 18 patients developed potentially fatal brain inflammation and two of them suffered strokes.

Not exact matches

But while thousands of clinical trials on immunotherapy drugs, of which many are predicted to fail, are springing up, the depth of information on neoantigen vaccines is much shallower: Just two studies on neoantigen vaccines for melanoma, recently profiled in Nature, were completed last year in Boston and Germany.

However, following devastating news that the Phase III RESOLVE trial of its RSV vaccine failed to deliver the desired results, Novavax, Inc. (NASDAQ: NVAX) shareholders are looking for any...

The long search for an AIDS vaccine has produced countless false starts and repeated failed trials, casting once bright hopes into shadows of disenchantment.

Vaccine proponents also point to the lessons learned from the failed Merck STEP trial.

In the coming months, scientists will have to evaluate the trial's full data to determine why the vaccine failed: Were the infecting viruses too different from the vaccine strain to offer resistance?

Clinical trials testing various cancer vaccines have failed miserably; in one, a melanoma vaccine called Canvaxin did not improve the survival of patients, an outcome that ultimately forced the drugmaker to sell itself to another firm.

Several vaccines against HSV - 1 tested in clinical trials for the prevention of adult - to - adult transmission have failed, Leib noted, but none have been tested for prevention of adult - to - baby so - called «vertical transmission» of the virus.

Howard Weiner, Danny Frenkel, and their colleagues built on the results of a failed 2003 Alzheimer's vaccine trial.

But the results of the clinical trial, first presented at a meeting a year ago, showed that the vaccine failed to raise an adequate CD8 + response, and it protected only two people.

Activists often slam large pharmaceutical companies for failing to develop drugs that are of critical importance to the developing world.Andrew Witty, GlaxoSmithKline's youthful chief executive, gave those critics pause yesterday in a speech to the Council on Foreign Relations in New York City.Witty promised to sell the company's malaria vaccine that is in late - stage clinical trials in Africa for no more than a 5 percent profit.

About 15 years ago, he led trials at pharmaceutical giant Merck on an especially promising vaccine — «the best hope we had,» Kim recalled — that ultimately failed.

High levels of inhibitory AMA1 antibodies were correlated with protection in a recent trial of AMA1 vaccines in Aotus monkeys [31], supporting the idea that AMA1 - C1 could have failed because it was insufficiently immunogenic.

The Step study, an international HIV vaccine trial co-sponsored by the National Institute of Allergy and Infectious Diseases and the pharmaceutical company Merck, was halted in 2007 when the vaccine failed to prevent HIV infection in volunteers or affect the virus load in those infected.

Recent attempts on extensive trials of cancer vaccines, using viral structures or substructures against several cancers such as cervices, prostate, lung, pancreatic and skin also failed to produce the overall protective clinical outcomes

In a parvo vaccine trial conducted by Dr Ronald D Schultz, head of pathobiology at Wisconsin University, three out of six parvo vaccine brands totally failed to give protection; two gave only partial protection; and only one was shown to be effective.