Sentences with phrase «failure risk by»

«In everyday terms our findings suggest that consistently participating in the recommended 150 minutes of moderate to vigorous activity each week, such as brisk walking or biking, in middle age may be enough to reduce your heart failure risk by 31 percent,» study senior author Dr. Chiadi Ndumele said in a university news release.

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

«It creates workplaces where taking chances and being creative while risking failure is subsumed by an ethos of mistake - prevention at the cost of daring and innovation.

Other risks it listed for potential investors include: A potential failure to attract new advertisers; the fact that most of its users are young, and by implication, fickle; and possible foreign government censorship.

That's because once you reduce the risk of failure by having a lot of people around who will hire you next, everyone becomes more open and friendly about what they are working on, which then further amplifies the benefits of having a lot of people around.

The new Alzheimer's framework may not be much of a surprise given numerous, high - profile, late - stage clinical trial failures in the field by companies like Eli Lilly and Merck, and the decision by other companies (such as Pfizer) to back away from the risk - prone field.

Proponents argue that blockchain technology could be used to reduce the risk of many IoT devices being compromised by a single point of failure, such as a server.

While I understood that failure was a fact of life — particularly that of a risk - taker — I also knew it was by no means a good thing.

If we want to «win championships» in both of those, we have to get others involved, pass more, risk failure, allow teammates to learn from their mistakes by letting them commit them and putting the needs of the group above our own selfish aspirations.

Beyond the benefits of a bigger after - sales revenue stream, OEMs will have a strong incentive to service these vehicles, since regulators could ultimately force them to take on the greatest portion of the responsibility and risk associated with crashes caused by AV technical failures.

By their nature, business investments involve the risk of failure — foreign or domestic.

Our use of derivatives may increase the risks of investing in the fund by increasing investment exposure (which may be considered leverage) or, in the case of many over-the-counter instruments, because of the potential inability to terminate or sell derivatives positions and failure of the other party to the instrument to meet its obligations.

These risks and uncertainties include food safety and food - borne illness concerns; litigation; unfavorable publicity; federal, state and local regulation of our business including health care reform, labor and insurance costs; technology failures; failure to execute a business continuity plan following a disaster; health concerns including virus outbreaks; the intensely competitive nature of the restaurant industry; factors impacting our ability to drive sales growth; the impact of indebtedness we incurred in the RARE acquisition; our plans to expand our newer brands like Bahama Breeze and Seasons 52; our ability to successfully integrate Eddie V's restaurant operations; a lack of suitable new restaurant locations; higher - than - anticipated costs to open, close or remodel restaurants; increased advertising and marketing costs; a failure to develop and recruit effective leaders; the price and availability of key food products and utilities; shortages or interruptions in the delivery of food and other products; volatility in the market value of derivatives; general macroeconomic factors, including unemployment and interest rates; disruptions in the financial markets; risk of doing business with franchisees and vendors in foreign markets; failure to protect our service marks or other intellectual property; a possible impairment in the carrying value of our goodwill or other intangible assets; a failure of our internal controls over financial reporting or changes in accounting standards; and other factors and uncertainties discussed from time to time in reports filed by Darden with the Securities and Exchange Commission.

Risks remain, including a failure by some OPEC members to stick to the plan, increased production by non-OPEC producers, and renewed weakness in global demand.

While no venture is a sure - fire success, you can minimize your risk of failure by starting a business in an industry with a positive drift.

As we wrote back in June about the systemic threat created by passive strategies: «If a key sector failure, a geopolitical crisis, or even an unknown, black box bias pulls an algorithmic risk trigger, will the herd run all at once?»

Toward the goal of clean capital markets, in 2004 Byrne began a vigorous citizen - journalist campaign focusing on regulatory capture, hedge fund mischief, settlement system failures, systemic risk, and the possibility of economic warfare against the US by organized crime and foreign governments.

The group also challenged her to take the leap — at the risk of possible failure — by enrolling in one course to test and toughen flabby academic muscles.

A WWEMP is a comprehensive undertaking that considers all site specific conditions and reduces the risk of effluent plant failure in the long run by establishing water management measures from factory floor to end - of - pipe treatment and beyond.

He usually gives some of the kids a run out but he can't be so stupid as to risk more failure when the league has long passed us by.

The process of developing a title winning squad by buying one high cost component every year, run the risk of failure when the other players become disenchanted with the team along the way, especial if there is not any trophies, they will want to move on to ensure they win something of substance in the best years of their career, while this is being done other teams will be finding the individuals needed to make a proper title run, some will do this by buying the expensive players and others will scan the various leagues to get a proper reasonable option to fill their needs.

Failing to convince Sanchez to sign a new contract and failing to sell him when he refused and replace him by a Lemar or Draxler can only be seen as a failure and a risk.

A study of infants in England indicated that supine sleeping is not associated with an increase in significant morbidity outcomes, and the risk of respiratory problems was reduced compared with that of prone sleepers.17 In Asian countries, aspiration is not a problem despite the traditional practice of placing newborns to sleep in the supine position.18 The review by Malloy19 of US vital statistics mortality files for the years 1991 to 1996 showed no significant increase in the proportion of postneonatal mortality rate associated with aspiration, asphyxia, or respiratory failure.

By the way, while failure to gain weight can happen to any baby, premature babies are at a higher risk than full - term babies.

The announcement was merely another indicator of the AFL's determination to avoid accepting the true risks posed by head injury, and so its failure to look after those its success as a sport depends upon.

We also need to strike a balance by providing children enough room to experience some hardship or face a risk of failure in order to cultivate the skills to overcome setbacks and the ups and downs of daily life.

The inequity experienced by pregnant women living in rural and remote locations forced to travel long distances to access maternity care, is raised as a failure of government to provide essential services to these communities [31 — 33] placing lives at risk.

The real risk is that posed by developers» failure to engage in community consultation.

Earlier this year, the Major Projects Authority revealed that the scheme had been «reset» by auditors, following earlier assessments that the scheme was at serious risk of failure.

This asymmetry of goals translates into mistrust, creating failures and sub-optimality in the market by increasing uncertainty and risk.

With the scope of the health risks still unclear, a class - action case against New York City, in connection with the failure to conduct lead inspections in public housing, is now being prepared by a lead lawyer for families suing over lead poisoning in Flint, Mich..

«This is an addition to too many pupils and staff being put at risk by the failure of the Coalition to tackle seriously asbestos in our schools.

The bombshell audit by state Controller Thomas DiNapoli found the state Office of Temporary and Disability Assistance's failures resulted in a «range of substandard living conditions, the most egregious of which pose obvious and dangerous risks to shelter residents» health and safety.»

Malloy said a failure by the legislature and Teamsters Local 1150 to approve the deal would put thousands of well - payingmanufacturing jobs across the state at risk.

Today, Donohue called the failure of the Close to Home program «further evidence of the failure of Governor Andrew Cuomo's public policy by news release that puts people at risk.»

One party insider said there has been a fierce debate within the Miliband circle between those who believe that the reforms are a key test of his leadership and that a failure to introduce radical change would substantially damage his credibility - and those who feel he risks putting the party's financial viability at risk by allowing union members to opt out of their so - called political levy contributions to the party.

Part - funded by the British Heart Foundation, the study shows that drinking more alcohol is associated with a higher risk of stroke, fatal aneurysm, heart failure and death.

Atrial fibrillation, diagnosed in 3.4 million Americans and the most common heart rhythm condition in the United States, is marked by irregular and sometimes extremely rapid heart rates that cause fatigue and shortness of breath, and significantly increase the risk of heart failure and stroke.

However, spironolactone did reduce the major burden faced by these patients - the risk of repeated hospitalizations for heart failure.

And as the failure of BAX 499 shows, the risks posed by any new medication can be hard to predict.

Since osseointegration is influenced by bone metabolism, this study investigates the association between SSRIs and the risk of failures in osseointegrated implants.

One in four patients develop heart failure within four years of a first heart attack, according to a study in nearly 25,000 patients presented today at Heart Failure 2016 and the 3rd World Congress on Acute Heart Failure by Dr Johannes Gho, a cardiology resident at the University Medical Center Utrecht, in Utrecht, the Netherlands.1 Risk factors included older age, greater socioeconomic deprivation, and comorbidities such as difailure within four years of a first heart attack, according to a study in nearly 25,000 patients presented today at Heart Failure 2016 and the 3rd World Congress on Acute Heart Failure by Dr Johannes Gho, a cardiology resident at the University Medical Center Utrecht, in Utrecht, the Netherlands.1 Risk factors included older age, greater socioeconomic deprivation, and comorbidities such as diFailure 2016 and the 3rd World Congress on Acute Heart Failure by Dr Johannes Gho, a cardiology resident at the University Medical Center Utrecht, in Utrecht, the Netherlands.1 Risk factors included older age, greater socioeconomic deprivation, and comorbidities such as diFailure by Dr Johannes Gho, a cardiology resident at the University Medical Center Utrecht, in Utrecht, the Netherlands.1 Risk factors included older age, greater socioeconomic deprivation, and comorbidities such as diabetes.

«Substance abuse is the topic of high public interest, yet little attention is given to the experiences of college students with disabilities,» wrote the study authors Steven L. West et al. «Given that binge drinking is highly correlated with academic failure, drop - out, and an increased risk for various negative health conditions, such use by students with disabilities may place them at extreme risk for various negative outcomes.»

The findings published in the New England Journal of Medicine found the drug canagliflozin reduced the overall risk of cardiovascular disease by 14 per cent and reduced the risk of heart failure hospitalisation by 33 per cent.

By taxing the transactions that create greater risk of network failure, the tax, known as a Systemic Risk Tax (SRT), would essentially rewire the financial system into a more resilient frisk of network failure, the tax, known as a Systemic Risk Tax (SRT), would essentially rewire the financial system into a more resilient fRisk Tax (SRT), would essentially rewire the financial system into a more resilient form.

Drought will not leave your glass empty: Low risk of hydraulic failure revealed by long - term drought observations in world's top wine regions.

«If clinicians decide to prescribe spironolactone to their patients to reduce their risk of being hospitalized for heart failure, there is an associated responsibility to monitor for serum markers of kidney and electrolyte disorders which can be exacerbated by spironolactone.»

We get heavily hyped drugs like Avastin, which shrank tumors without adding significant time to cancer patients» lives (and increased the incidence of heart failure and blood clots to boot); Avandia, which lowered blood sugar in diabetics but raised the average risk of heart attack by 43 percent; torcetrapib, which raised both good cholesterol and death rates; and Flurizan, which reduced brain plaque but failed to slow the cognitive ravages of Alzheimer's disease before trials were finally halted in 2008.

For example, while insulin secretion failure is by far the most prevalent at - risk phenotype in normal weight subjects with prediabetes, fatty liver and visceral obesity become more prevalent in overweight and obese subjects.

And yet the risks posed by deep - sea operations — and specifically the potential impact of the failure of key systems — have long been understood.